Antifungals and probiotics Caution: most of the information collected here originates from manufacturers so please consider your options carefully. Some comments have come from users of these products, but as we know from our experiences with other medication each of us is different and may react differently to these products too. Name
Vitamins, minerals and herbs used to support health and detoxification.
J Med Microbiol. 2006 Jul;55(Pt 7):879-86.
Naturally occurring amino acids differentially influence the development of Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae.
Al-Younes HM, Gussmann J, Braun PR, Brinkmann V, Meyer TF.
Department of Molecular Biology1 and Microscopy Core Facility2, Max-Planck-Institute for Infection Biology, Schumannstr. 21/22, 10117 Berlin, Germany.
The differential influence of individual amino acids on the growth of Chlamydia trachomatis versus Chlamydia (Chlamydophila) pneumoniae was investigated. Certain essential amino acids added in excess at the middle of the infection course resulted in varying degrees of abnormality in the development of the two species. If amino acids were added as early as 2 h post-infection, these effects were even more pronounced. The most effective amino acids in terms of C. trachomatis growth inhibition were leucine, isoleucine, methionine and phenylalanine. These amino acids elicited similar effects against C. pneumoniae, except methionine, which, surprisingly, showed a lower inhibitory activity. Tryptophan and valine marginally inhibited C. trachomatis growth and, paradoxically, led to a considerable enhancement of C. pneumoniae growth. On the other hand, some non-essential amino acids administered at the middle of or throughout the infection course differentially affected the development of the two species. For example, C. trachomatis growth was efficiently inhibited by glycine and serine, whereas C. pneumoniae was relatively less sensitive to these agents. Another difference was apparent for glutamate, glutamine and aspartate, which stimulated C. pneumoniae growth more than that of C. trachomatis. Overall, several distinctive patterns of susceptibility to excess amino acid levels were revealed for two representative C. trachomatis and C. pneumoniae isolates. Perturbation of amino acid levels, e.g. of leucine and isoleucine, might form a basis for the development of novel treatment or preventive regimens for chlamydial diseases.
David Wheldon offered this citation as another good reason to use alpha-lipoic acid as a supplement on the protocols here. This study notes it's anti-inflammatory effect through T-cell inhibition. Although this study is orienting from the autoimmune model of MS, David notes " I read this as positive, if you are taking antibiotics. While killing the organisms you want as little inflammation as possible."Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis.Marracci GH, McKeon GP, Marquardt WE, Winter RW, Riscoe MK, Bourdette DN.
As we know, Cpn binding endotoxin uses up melatonin and supplementation has been helpful to a lot of us. In addition it's an excellent antioxidant. The study below adds even another reason to supplement it:
J Pineal Res. 2005 Oct;39(3):266-75.
Melatonin neutralizes neurotoxicity induced by quinolinic acid in brain tissue culture.
Cpn exploits a variety of mechanisms to thwart our immune system. There is one mechanism that is particularly important and can be countered by over the counter supplements. Cpn targets niacin metabolism. In doing so it leads to impaired T-cell function, low melatonin, low serotonin, low tryptophan, low niacin all of which can present as depression, fatigue and insomnia, all familiar symptoms in Chronic Fatigue, Fibromyalgia and a host of Cpn related disorders. Niacin therapy has been used safely for the treatment of hypercholesterolemia for decades, just the same, niacin levels should be increased slowly to minimize flushing and liver enzymes should be monitored. Expect some endotoxin release (as organisms die) as niacin is increased. Endotoxin release will lower nitric oxide levels temporarily and lead to cold hands and feet and possibly increased muscle aches in the initial stages of niacin treatment. You have to build up gradually on niacin as ingestion causes a flush like a hot flash. This reaction abates as you get used to the increased levels, and you can increase (UP TO???) the dose as tolerance develops. Eventually time-released niacin can be used after niacin tolerance is established, but this form of niacin can be harder on the liver. Just be careful and make sure your doctor is monitoring liver enzymes and CBC every month or so until tolerance is well established. Unfortunately Niacinamide, ("No Flush Niacin") does not appear to be as effective. Adding herbs that increase nitric oxide synthase (NOS) activity can also be helpful and can lead to improved immune function and warmer extremities. Garlic, ginseng, & ashwagandha all increase the activity of NOS and may be synergistic in combination with niacin. Increasing nitric oxide usually decreases FM related muscle pain and anxiety. One of the following articles supports the use of niacin for chronic headache (Mayo Clinic article) and another links infection with Cpn to disruption of niacin metabolism and immune evasion.Make sure that you are taking a good multivitamin daily when doing battle with Cpn. Nutritional demands are increased significantly by increased exposure to the endotoxin that is released from dying organisms. Biochemicals made by the the body to fight Cpn are made at the expense of tryptophan, niacin, melatonin, and serotonin all of which also are needed to fight Cpn in other ways. Supplementation with niacin and melatonin should make life more difficult for Cpn. Best wishes to all of those who striving to be a bad host to Cpn. The last two articles document the effects of nitric oxide and melatonin on Cpn.
This page is for all those who are using vitamin D supplementation as part of their protocol. It is clear that what medical people were taught and what appears to be true about vitamin d levels and human nutrition are different. Here is a wonderful presentation on vitamin D offered by a researcher. Please be aware, this presentation requires a fast connection like DSL or cable. It's essentially a DVD of a presentation with 68 slides offered alongside showing the research findings.This paper focuses on MS and vitamin D specifically "Vitamin D and Calcium Deficits predispose to MS" This is a link out to pubmed.
Biochem Biophys Res Commun. 2005 Jul 22;333(1):21-7.
Resveratrol and curcumin reduce the respiratory burst of Chlamydia-primed THP-1 cells.
Deby-Dupont G, Mouithys-Mickalad A, Serteyn D, Lamy M, Deby C.
Center for Oxygen, Research and Development (CORD), Institut de Chimie, B6a, University of Liege, Sart Tilman, Belgium.
The intracellular bacterium Chlamydia pneumoniae is involved in the inflammation process of atherosclerosis. We previously demonstrated that C. pneumonia infected monocytes (THP-1 cells) responded to stimulation by an increased respiratory burst linked to an increased NADPH oxidase (NOX) activity. We now tested agents acting on the assembly of the NOX subunits or on protein kinase C, a trigger of NOX activity. Apocynin, resveratrol, rutin, quercetin, curcumin, and tocopherols were tested. The cells were pre-incubated with Chlamydia and the agent for 19 h, and then stimulated with phorbol myristate acetate. The NOX activity was monitored by measuring the hydrogen peroxide production. Resveratrol and curcumin (10(-4)-10(-6) M) were better inhibitors than apocynin. alpha-Tocopherol was inactive, and gamma-tocopherol inhibitor at 10(-4) M only. Quercetin was inactive, and rutin a moderate but significant inhibitor. The inhibition by resveratrol was increased by 10(-6) M rutin or quercetin. Resveratrol and curcumin thus appeared to be interesting for atherosclerosis treatment.