24 Mar 2022 10:21 am
24 Mar 2022
Title
my thoughts if you should take minocycline or doxycycline
Body
i used mino when i first used the abx for only 3 months
minocycline
pro:
- mino stopped my depression almost immediately (few days). mino is known to be anti inflammatory (microglia).that might be the reason. anti neurodegenerative?
- mino has a better penetration into the brain than doxy. some might benefit from this.
cons:
- maybe microglia activation is useful in the context of an infection with dying bacteria.
Comments
24 Mar 2022 03:15 pm
I'm not sure if that …
I'm not sure if that "microglia" business refers to the same paper I looked at a while ago, but what struck me was that the level at which they found minocycline to have an anti-inflammatory effect was hundreds of times larger than the level that is reached with ordinary doses of the drug. Nevertheless a whole lot of other papers were gleefully citing it as evidence that minocycline's clinical effects were due to its anti-inflammatory properties. It served as an excuse to ignore the possibility of infection.
https://pubmed.ncbi.nlm.nih…
https://pubmed.ncbi.nlm.nih.gov/31078757/
https://www.nature.com/articles/cddis201354#:~:text=Minocycline%20is%20….
https://academic.oup.com/brain/article/141/2/459/4764007 this one is on humans actually.
i also read in one study abstract that it is widely recognized that minocycline has anti inflammatory properties.
whatever.
mino definitely helped with me depression last time. but is it actually a good way to reduce inflammation/depression (if that is actually what is happening when taking mino) or is it a reparative effect the microglia play? like the last study says "These findings suggest that microglial activation has a reparative effect in the chronic phase of traumatic brain injury."
i would just be interested in your opinion and anyone elses. just opinions. i know that basically nobody can really say what to do here (or i would be very surprised)
chlamydia pneumoniae and mycoplasma pneumoniae diagnosed 2021, had infection probably since 2018 (antibodies tested positive 09/21, no test done before);
26 Mar 2022 11:48 am
Okay, that's different (and…
Okay, that's different (and more recent) work. That mouse work is still using high-ish doses, though not at the crazy level of the earlier paper. 20 mg/kg would mean a dose of 1400 mg in a 70kg human, and they also used 50 mg/kg. But perhaps that's justifiable by mice having a higher metabolic rate. That's the first paper; the second one uses 33 mg/kg, also in mice. The third is on humans, with normal minocycline doses.
In humans, one can suspect that infection plays a role. Cpn infects white blood cells (two different studies found it in 20% of healthy blood donors) and can ride in to damaged areas and set up shop there. So minocycline can be stopping post-injury inflammation by stopping the root cause for that inflammation: infection.
Anyway, inflammation is generally a part of healing, so no surprise that there would be a "reparative effect" in the long term.
24 Mar 2022
i used mino when i first…
i used mino when i first used the abx for only 3 months
minocycline
pro:
- mino stopped my depression almost immediately (few days). mino is known to be anti inflammatory (microglia).that might be the reason. anti neurodegenerative?
- mino has a better penetration into the brain than doxy. some might benefit from this.
cons:
- maybe microglia activation is useful in the context of an infection with dying bacteria.
- mino has more side effects usually (possibly also more sever ones like Intracranial Hypertension) compared to doxy
- mino is more expensive (i just read this. dont know if its true)
- mino is said to be less effective in killing cpn than doxy
well i still have depression problems after being on azi 250mg for 4 months now. can not add doxy yet. im thinking about adding mino because of the anti depressive effects too... not sure what ill do.
just wanted to put my thoughts here maybe someone can benefit from it.
chlamydia pneumoniae and mycoplasma pneumoniae diagnosed 2021, had infection probably since 2018 (antibodies tested positive 09/21, no test done before);