I've been lucky, I've had reactions, but nothing too terrible.Then ... Two days ago I had a massage, to try and help my drop-foot, I hate massage but know, and trust, the masseur, so gave it a go. it helped! I think! She explained how supplements and ABX can't get around tense muscles. Apart from paresthesia, which is horrible, horrible, horrible, I get a restless leg, but that hasn't been around, since the massage, it also decided me to take my NAC regularly, it has made me nauseous in the past, but it was time to start being brave! I'm only taking 600 mg a time, so far, but, But, I really know it's in there! My fatigue, drop-foot and sight are even worse! In time, I'll increase the dose, but not until after I've taken my next pulse, next week. Do you think this is a good die-off reaction? If so, it's worth it! If not, maybe not!Up-DateI've stopped using NAC, for now. The reaction became more and more severe and didn't seem to be the norm, as reported on this site, so, although I hardly slept last night, we went for a long dog wlk, early today, and, I'm so happy to report, my drop-foot (functional weakness) was hardly evident! I'm booked more massages, expensive, but worth it, although my restless leg, has bothered me, just a little! I know I should take NAC, but, mayb another time!