27 Apr 2018

Interesting Perspective Article on Vit D3 and Septicemia


Here's an interesting perspective article on the potential for Vit D3 to reduce the risk of septicemia.   It's well worth a read since it discusses the anti-endotoxin effects of Vit D3, an area we have discussed on the site before, but not in much detail: Perspective: Solar ultraviolet-B irradiance and vitamin D may reduce the risk of septicemia


Red- this article, although focused on septicemia, actually has a good review of the impact of Vit D on a number of health conditions. Really worth downloading and reading. The anti-endotoxin aspects are also of note. Thanks.

Thought the 2nd link Red posted above was worth pasting directly. Very interesting stuff.

Cathelicidins and functional analogues as antisepsis molecules

The emergence of antibiotic-resistant bacteria together with the limited success of sepsis therapeutics has lead to an urgent need for the development of alternative strategies for the treatment of systemic inflammatory response syndrome and related disorders.

Immunomodulatory compounds that do not target the pathogen directly (therefore limiting the development of pathogen resistance), and target multiple inflammatory mediators, are attractive candidates as novel therapeutics.

Cationic host defence peptides such as cathelicidins have been demonstrated to be selectively immunomodulatory in that they can confer anti-infective immunity and modulate the inflammatory cascade through multiple points of intervention. The human cathelicidin LL-37, for example, has modest direct antimicrobial activity under physiological conditions, but has been demonstrated to have potent antiendotoxin activity in animal models, as well as the ability to resolve certain bacterial infections.

A novel synthetic immunomodulatory peptide, IDR-1, built on this same theme has no direct antimicrobial activity, but is effective in restricting many types of infection, while limiting pro-inflammatory responses. The ability of these peptides to selectively suppress harmful pro-inflammatory responses, while maintaining beneficial infection-fighting components of host innate defences makes them a good model for antisepsis therapies that merit further investigation.

Hunter: Don't think - experiment