27 Apr 2018

Common acne drug (Minocycline) could treat MS


Unfortunately, they don't explain beyond 'it helps'.  I'm going to bet "Jill" ends up sliding downhill again soon.  I hope I'm wrong.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi


Their reasoning is that solo minocycline works in MS by means of its immunomodulatory properties. Infection is not considered. Several years ago I wrote to Luanne Metz but received no reply. Of course she may not have received my email.

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. No medication now. Morning BP typically 110/75]

Well, on ThisisMS, a man from the mid-west with multiple sclerosis whose name I don't remember, was taking minocycline very successfully for several years, until he had a relapse.  I don't know what he did then...........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

A neurologist who I saw many years ago started me on 10 days of minocycline because he thought it might be beneficial.  I saw improvement and begged him for another course.  He agreed to one more but was not willing to go any farther.  His name is Dr. David Perlmutter.  I am grated to him as that is what prompted me to pursue the antibiotic protocol through Dr Sriram at Vanderbilt University MS clinic.  In fact, I see Dr Sriram tomorrow for my yearly appointment.

 Started Vanderbilt protocol 1/9/08  Rifampin once a day, b12 injection monthly , vitamin D 50,000 IU weekly

Minocycline is the first drug that I introduce in the CAP protocol, using the same dose as in this recent study of 100mg twice daily for patients over 75kg weight and reducing that dose for lower weights. It is interesting that in this study, benefit was seen at 6 months, but not at 24 months. This is to be expected. Using Minocycline as the only drug will cause persistence of the Cpn. I add Roxithromycin 300mg daily after 2 weks, as a "back-up"to the minocycline, then Tinidazole with monthly pulses of 500mg twice daily for 2 days after 1 month to kill the persistent or cryptic form. NAC to treat the extracellular spore is added later as this tends to cause most side effects if introduced too early. I then add in Resveretrol 250mg twice daily and check the patient's serum lipids. If the LDL is greater than 2.5 I recommend introduction of a statin (usually Rosuvastatin) at a low dose of 5mg, then increasing it slowly over a period of months to aim to get the LDL less than 2.0. (Cpn disturbs lipid meteabolism and oxidises LDL). Most of my patients with chronic persistent Cpn have high LDL levels. Virtually none of them drink red wine. I aim to wean the patient off the CAP at around 18 months, usually by stopping the minocycline first, then 6 months later the roxithromycin, then finally the Tinidazole. So that is my current vascular approach to chronic persistent Cpn infection.