MediTest
27 Apr 2018
Author
BradW in GA
Title

Zith vs. Roxy - how much difference?

Body

Zith vs. Roxy - how much difference? why a different herx? which's better?

Comments

Brad, DX: ALS 2/06. EBV. Lyme tests negative twice... 14hrsInBed/Day. 2006 - 1 yr. on MP / progression all but halted? / Benicar problems
1/7/08 WheldonCAP started Suppliments&NAC
1/21/08 1xWk. Zith 125mg 63mg

Brad, DX: ALS 2/06. EBV. Lyme tests negative twice... 14hrsInBed/Day.  1/7/08 WheldonCAP started Suppliments& 1200mg NAC1/21/08 1xWk. Zith 125mg 63mg

Hi Brad,

I don't think there is a difference; I stand to be corrected.  Some people experience depression from Azith & switch to Roxy because of it.

I am from Canada, we don't have Roxy, so I just toughed the Azith out.

Hope this helps

CFIDS/ME 25yrs, FMS, IBS, EBV, Cpn, (insomnia - melatonin, GABA, tarazadone, triazolam, novocycloprine, allergy formula, 3 gm tryptophan), Natural HRT peri-M, NAC 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, 2-6-08 6th pulse 1 X 375 mg 5day

CFIDS/ME, FMS, MCS, IBS, EBV, CMV, Cpn, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplements+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyl/day-5 days<

 Hi Brad - The difference between roxithromycin and azithromycin are primarily activity in vitro (test tube) towards certain pathogens and ability to cross the blood brain barrier. 

There is some evidence that roxithromycin is superior in crossing the blood brain barrier.  Azithromycin penetrates tissue extremely well.  Unfortunately it leaves virtually no drug in the serum and there are some german studies regarding septicemia developing in pneumonia patients on azithromycin because the serum is left unprotected.  For this crowd however this issue shouldn't be a problem.

For my husband, he was taking azithromycin 375mg daily.  He was switched to roxithromycin 300mg twice daily.  Wham - huge difference.  He had major herx reaction and then began to slowly improve.

 Daisy  - Husband on CAP 5/07.  Mino, Roxy, Diflucan round two 1-31, Rifampin, Bactrim DS,  Prednisone, Novantrone, Doxy, Azith

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him. Daisy on her own CAP 11/2012. 

 

Brad, I always took roxithromycin and I guess maybe that is one reason why I improved so quickly.  I've got one of those German papers, but I can't find it: I must improve my filing system!..........Sarah

An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still slowly improving and no exacerbation since starting. EDSS was 7, now 2, less on a good day.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Brad, several reasons I chose Roxi.   One is the reason stated above by Daisy and Sarah about blood brain barrier.  Of Course the Doxy crosses the blood brain barrier well too and that is why I stuck with it even though it is hard on my stomach without a full meal including fats, proteins and carbohydrates to moderate this, which has improved.  So if you take Azytho and doxy you are covering that aspect in my opinion from my reading.

My second reason is that my insurance company has a policy to deny use of Azythromycin for more than 28 days for Lyme that was recently adopted.  The politics are interesting if they don't affect you right?  Anyway if I was going to be self paying I decided to give Roxi a try. it is easy on the stomach even empty and I had no associated feelings of heaviness (depression?) that some folks report with Azythromycin.  

Louise

CFS/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, TiniPulse#4 Ended2/3/08. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Louise, you don't take azithromycin and roxithromycin together because they are both macrolides.  Brad, with ALS, needs to take something like rifampin with one or the other of them, but I think he knows that.............Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Sarah, I am not sure how you read that I was suggesting that azythromycin and roxithromycing should be taken togther I completely understand that they are both macrolides and you do either one or the other.  I chose Roxi for the reasons I stated above.  It is Garcia that is taking both Azythromycin and Roxithromycin as well as Doxycycline at the same time. in a discussion on another topic.

Louise

CFS/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, TiniPulse#4 Ended2/3/08. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

A case of mistaken identity Louise, my apologies!....SarahImage removed.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Sarah you should know by now that any craziness on this board is more than likely confined to me! I've repented though and am soon to give up the Azith & Roxy combo. Soon no one will be taking that.

CFS. Started CAP 03-07.
Currently: Azithro+Roxi+Doxy. 8 Pulses done. Welchol 4xday. Sauna every other day. D 7200IU

Hunter: Don't think - experiment

Brad- I have to say that I never noticed a difference a year ago when I tried Roxy for a month... BUT... I've changed my mind. I think there are good arguments especially for your disease. 

I had about two weeks dosing left over and needed a shorter acting macrolide for some experimenting I was doing with pyruvate, blah, blah, blah. The upshot was that I felt much better on the roxy after week one, particularly an improvement in mental clarity and focus. I suspect that when I tried it last year any improvements were lost in the stronger welter of reactions I was having generally.

Daisy's explanation of the way more of the drug stays in the serum makes sense, and the better blood-brain barrier penetraion will have particular importance for some of us. Certainly for your case and I believe for mine as well (Alzhiemer's runs in my family, which is a Cpn related disease as we know from Balin's brilliant work).

I obtained mine through this on-line and got the non-generic in the foil sealed packets. If I go back to it, I'll try the generic to see if the quality appears the same as it's much cheaper.

On related note, I'm experimenting with using Biaxin (again with the pyruvate an hour or so before) instead of azith and noticing that it has a much more potent impact-- I've not had hardly any die-off from azith any more, and this provokes significant reaction. I'm only a couple days into it, so I don't have the expected improvements yet.

Daisy, any comments on pharmacological differences that might help explain this?

CAP for Cpn 11/04. Dx: 25yrs CFS & FMS. Protocol: 200mg Doxy, 500mg MWF Azith, Tini 1000mg/day pulses; Vit D1000 units, INH 150mg, Magnascent Iodine 20 drps/day, T4 & T3

 

Jim, I've bought roxithromycin from there and can vouch that the stuff labeled Aventis is genuine.  I wouldn't risk the non Aventis stuff, though, since it might not have enough f the real ingredient, since roxithromycin is still under patent.  Brad can't risk this being the case...........Sarah

An Itinerary in Light and Shadow...........Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still slowly improving and no exacerbation since starting. EDSS was 7, now 2, less on a good day.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Garcia, I can be pretty crazy myself sometimes!..........Sarah Image removed.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.