27 Apr 2018
Author
MacKintosh
Title

Yikes! Combo drugs reported to 'heal' MS!

Body

This morning, a friend emailed the entire article to me (Don't know if I can make the link work here...)  The thrust of it is mixing an anti-cancer drug with Copaxone (it was overlapped, as they planned to wean patients from Copaxone) has 'cured' several people and now trials will be undertaken in England.  Unfortunately, one of the side effects of this cancer drug is leukemia.  The best part of the article, though, is the head of the MS society says it's obvious drug COMBINATIONS are the way to go to wipe out this disease.  Well, duh.  And, let me just ask, wouldn't this cancer drug be res

Comments

Hi MacK,

This is what I know about Mitoxatrone (Novantrone)--it is a anthracycline antibiotic. This is a class of drugs that is indeed active against bacteria but was shown to be too toxic for that use alone. I think in the 50's and 60's it was shown to have anti-tumor/cancer effects. Please, anyone correct me if I am wrong!

Fast forward to 2006 and they are using it to treat this horrible autoimmune condition MS along with the neuroprotective Copaxone. Now, I am a stupid idiot (it's true, really.....) but this sounds to me like killing a fly with a Katyusha rocket (those that are used by Hezbollah against Israel). Yay, they will have a large scale trial of this highly toxic drug cocktail but no one will bother undertaking a study for relatively benign abx. I do indeed think I live in a world of complete and utter madness!!!

Lexy

---------------
"Chance favors the prepared mind." --Louis Pasteur

Husband treating MS with CAP

Agreed.  But why do what's simple and cheap and relatively benign when you can spend tons of money, take the chance on inadvertent suicide and lie in a hospital bed paralyzed while you wait out the treatment?  We live in the Twilight Zone, I swear.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems.  Mohandas Gandhi

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Novantrone is the one that causes heart failure after 33 months of use in addition to a small increase in chance to contract leukemia. Indeed, it still doesn't surpass Tysabri in its safety on my list of good stuuff medicine offers to us. Best wishes.

Cured of multiple sclerosis, stopped the Wheldon's protocol in Nov,2008. Use only LDN.

This subject also made an appearance in today's papers in the UK.   I was kind of interested because Mitoxantrone is one of a cocktail of drugs my husband is receiving to treat leukemia.   This is a bit of text I found on Medline plus:

Mitoxantrone seems to interfere with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by mitoxantrone, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Elsewhere I read that its effect is to dampen down the immune systems (as immuce system cells are fast replicating cells too).  

I'd rather stick to the CAP. 

Michele:  on Wheldon protocol since 1st May 2006 for a variety of long standing ailments, also spokesperson for Ella started Wheldon protocol 17th March 2006 for RRMS

Sussex, UK

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

Mitoxantrone is an anthracycline analog, maybe less toxic for cancer sufferers than idarubicin, a true anthracycline antibiotic.  If one is using it one is liable to acquire infections which would still need treating with normal antibiotics.  Used by itself as an MS treatment, you can only have a certain number of infusions, ever, because it is so toxic.  The theory behind this trial seems to be to carefully select the MS sufferers,  who have very active but not yet progressive disease, give them a short burst of mitoxantrone then carry on with copaxone.  This will probably hold the disease in abeyance for a while, but as with campath (lucky I missed out on their trial for SPMS people, although I live in the Addenbroke's catchment area), no-one can know what is going to happen in the future.  They are reporting for the mitoxantrone/copaxone trial that there are people who have made near miraculous improvements, but that is what drugs companies do.  It just isn't true that everyone is going to have been nearly paralysed and then will suddenly leap out of their wheelchair and get on with their new found life.  We all know that: that is why we are here.  I guess that in the long run its aim will be even worse than a Katyusha rocket, except that there will be far more people adjudged not suitable for treatment in the first place, whereas Hezbollah just want to get as many Israelis within reach as possible, more's the pity.

Sarah

 

Started the Wheldon regime in August 2003, due to very aggressive SPMS.  Moved to intermittent therapy after one year.  In May 2006 still take this, two weeks every two months.  EDSS was about 7, now less than 2.

An Itinerary in Light and Shadow  Berger.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I read this - what I hate most about these stories is my phone will ring from friends and relatives regarding a new cure for MS and I may say - go ahead and try it but I am not interested.  They think it is because I am stubborn and I am thinking, I am not stupid.  I think its funny how we always have to mix drugs up a, b,c,r, and add another one - have to keep the a, b, c drugs alive as "they work so well"

 

 

 

On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , LDN 2004

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

Wiggy, even I get the mainly emails and text messages from friends and relatives telling me about this sort of thing, and I'm married to the person who set me on the right track in the first place! I think they email and text because they know what I am going to say and don't want to speak in person for that reason, but just feel they ought to say something in case I had missed it (as if) and don't want to deny me the chance of something wonderful.  Well, I hope so anyway.......Sarah

 

Started the Wheldon regime in August 2003, due to very aggressive SPMS.  Moved to intermittent therapy after one year.  In May 2006 still take this, two weeks every two months.  EDSS was about 7, now less than 2.

An Itinerary in Light and Shadow  Berger.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Sarah,

I can't believe they are still sending MS treatment emails on to you - but you are right - their hearts are in the right place, always trying to help us out.

 

My legs are in great shape - not spastic this week!  They have not been like this for years and I am not sure how long it will last but I'll take it for as long as it lasts.

 

 

 

On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , LDN 2004

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

Good news about your legs Wiggy, long may it continue.

Not only do I get e-mails, letters and conversations from family and friends regarding new 'treatments', but I also get it from my husband.   Several times people have given me information about other chronic neurological diseases such as ME (CFS) and MND, they get confused with all the Ms.   A couple of people have confused Candida and Chlamydia Pneumoniae. 

I think they feel helpless and that it gives them something to feel good about.   I have heard it said that there is no such thing as a selfless act...  I know how bad it can feel to be completely helpless.   These same people are often the one who send me money to pay for this treatment, so I just say 'thanks, I'll look into it' and most of the time dismiss it.

Michele:  on Wheldon protocol since 1st May 2006 for a variety of long standing ailments, also spokesperson for Ella started Wheldon protocol 17th March 2006 for RRMS

Sussex, UK

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

HI everyone! Wiggy I have had spasms for years. When I say spasms I mean that my legs bend at the hip and knee and ankle all of these joints flexing as if to make a really big marching step all on their own with me having no say so about it. These are typical flexor spasms for MS though some doctors have called it "restless legs" as well. The deciding thing is that these particular spasms are not related to activity like standing up but occur of their own accord when you are resting or trying to rest. I used to take 2 pills of requip at bedtime to help me sleep as these constant ( every 5-50 seconds until I dropped off exhausted) very strong spasms which would make me writhe uncontrollably and sometimes even strained my muscles. I had also taken baclofen, sinemet, flexoril and clonazepam for this at other times.
About pulse 4 I noticed I was not very spasm-y (and I had always had some even on the meds). I decided to try not taking my med that night and I incredibly enough slept. Now, I had tried this MANY times before because I felt the meds made me weak but I was never able to get more than half a night then I would give in and take my two pills again. Since that time 7 months ago I have taken perhaps 4 pills TOTAL. On rare nights I felt some spasms, even those are shadows of what I used to experience even ON the meds. This is a miracle for me I have been pretty much spasm free for about 7 months now. If you read my blog you will see I am still waiting to walk like a normal person (patience!), but this change was the big first one for me that let me know something positive was happening and to be honest with you, if given the choice I would have chosen it. Spasms are MISERABLE...relief is a miracle. I wish you the same story!
Blessings
Marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

 

 Michele - Sorry to hear that friends and relatives are after you when it comes to treatments and I have been thinking about how we can get your husband on board here.  It must be hard with you and Ella both on treatment.  I will keep thinking about this - does he come here to read the stories?

Marie, It is very exciting - my real first big sign - my legs are so stiff they do not bend and my husband tries to bend them to get me in the car - he is afraid he is going to hurt me as he sometimes uses lots of strength to bend them - I have tried zanaflex and baclofen but both drugs required me to sleep too much - drowsy.  My legs are worse in the heat - we went on vacation and the spastic legs disappeared in 80-90 degree weather.  We were both shocked and it is a miracle.  I expect they will be back as from what I have read here it goes back and fourth for months.  I was sick about a month ago and I was having major spasms, could not roll over in bed and could not really bend legs at all.  I have not got to flagyl yet, just 4 months of doxy and zithromax - I have the flagyl in my cupboard and I look at it everyday Image removed. - waiting for the right time - maybe Fall, I am enjoying my summer.  We are all are hoping you will be walking soon - patience is the hardest thing.

How are you feeling after surgery?

 

 

 

On Wheldon protocol for MS since April, 2006.  doxy 200 mgs daily, zithromax 250 mgs 3x/ week , LDN 2004

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.

I actually had the baclofen pump installed after trying baclofen, botox, and other meds.  Since implantation surgery earlier this year, I have been back and forth to the dr. for adjustments to the pumps.  After a month or so on abx and the pump set at 90 micrograms, I feel like my legs are spaghetti.  I kinda wished I tried abx before getting this pump.

HI Wiggy there are two Maries on this board....MarieM who I believe had surgery and me mrhodes40. I did not have surgery I hope Mariem is doing well!
Steve I am so glad to hear of your recent decrease in spasms on treatment.. It seems to be very consistent that people report decreased spasms. Someone, I believe it was notdoneyet, on Thisisms reported that after going to intermittant therapy he discovered he was not yet done yet indeed as those pesky spasms did return (along with some other symptoms). He and his doctor decided he would go back to active phase of treatment and he went back on the regular protocol. Spasms seem to be a sensitive indicator. Is there anyone out there who had severe spasms that is now on intermittant therapy successfully remaining spasm free? I do not remember Sarah mentionning severe spasms, but it may simply be she just didn't mention such. I know Alex also has had huge relief of spasms but I believe she is also in active treatment and not yet switched to intermittant.
Marie
On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

Hi Wiggy,

Its not that my husband is giving me a hard time about the Abx, he knows that there is little alternative at this present time, but he does give me information about other treatment which is being published in newspapers, these reports are so often light weight and misinformed that I find them facile and misleading.   But I read them all the same, I don't want to miss anything that might help.   Hamish is not very au fait with the internet so only looks in at Cpnhelp if I show him something, and he certainly does not have the patience to read and research, neither for that matter has Ella.  

This is why this place is so great, I don't feel alone anymore... 

Michele:  on Wheldon protocol since 1st May 2006 for a variety of long standing ailments, also spokesperson for Ella started Wheldon protocol 17th March 2006 for RRMS

Sussex, UK

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

Marie,  I did have spasms that were getting worse, but not nearly as severe as some.  For quite a few years my right leg would do as you described, when resting, but a lot of the time I managed to hide it under the table.  It would also do this at night as well.  I was beginning to get quite a bad clonus on standing.  This all went sometime in the first year, then I stopped even thinking about it, or thinking that I used to have it.  I think I have mentioned it somewhere on ThisisMS, though.  I haven't had any recurrence since going onto intermittent therapy.  If I had I would just have restarted  active treatment at the drop of a hat.  As it was I did do my first intermittent bout after only a month for no other reason that I was scared of being cast adrift, by myself,  in what was in effect, a perfectly calm sea.......Sarah

 

Started the Wheldon regime in August 2003, due to very aggressive SPMS.  Moved to intermittent therapy after one year.  In May 2006 still take this, two weeks every two months.  EDSS was about 7, now less than 2.

An Itinerary in Light and Shadow  Berger.

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.