Cpnhelp.org

Oh there it is!!!!!!!!!!!!!!!!!!

___________________________________________________________

Wife with CFSⁱ/FM/REYNAULD'S 15YRS Lab positive for CPnⁱ/HHV7&11/EBVⁱ. Son 17yo with FM 3yrs- both on all supplementsⁱ since 8/08 Started CAPs per Strattons modification (clindy/pyruvate/doxyⁱ) started 11/17/08

Good luck with this LW, I'm not familiar with this modification.   The basis of a Combined antibiotic protocol is just what it says, more than one antibiotic taken in conjuntion.   The pyruvate may potentiate antibioticsⁱ but will do nothing to stop Cpnⁱ from becoming resistant to it.   Clindamycin is not on the list of Antibiotics that appear in the Stratton patent, but then maybe you have found out something that we don't know about.

___________________________________________________________

Michèle (UK) GFAⁱ: Wheldon CAPⁱ 1st May 2006. Daily Doxyⁱ, Azi MWF, metroⁱ pulse.

http://cpnhelp.org/emerging_stratton_protocol

this is the protocol i am referring to - per Dr Stratton. I do, I do, I do believe in CAPⁱ. this is only a modification he feels will possibly lessen the HSP60 release form the cryptic formⁱ.  His recent studies have shown that the CBs are NOT dormant but releases HSP60 a protien that may be exponetially more inflammatory than EB endotoxinsⁱ. Probably the reason the Flagyl pulses are so notorious. His reasoning as I percieve it is that the use of pyruvate will prevent EB'sⁱ/RBs from changing to the CB form (which they do when environmentally stressed). This may reduce the CB form load when it is time to add the Flagyl or Tiniⁱ and thus reduce the reaction (herx). Since the CB is the most difficult to eliminate this may even shorten the overall length of time needed to reduce the bacterial loadⁱ and recover lost function. Many of the studies in atherosclerosis and CPn relate the levels of HSP60 directly to the progression of  the disease.

Does that make any sense-I respect  your opinion having read so many of your blogs -You are one of those I mentioned in and eartier blog that kept me on the path to having the do the CAP.  

I haven't noticed any significant numbers following this "emerging protocol" but it makes sense to me.

"Now we see through a glass, darkly: but then face to face:now I know in part-but then I SHALL KNOW-" I COR 13:12.

Lance

From Dr. Charles Strattonⁱi, 4/24/08

My thoughts on the current Stratton Protocol is that this is a work in

progress, but given what we know now, it would be the following:

NACi 600 mg one a day to test "Chlamydial Load."

If no reaction, go to 1,200 mg twice a day.

If a severe reaction ("Flu-Like" reaction), use low dose prednisone (5 mg per day) for the first few weeks of therapy.

The next step would be two weeks of a macrolide (clarithromycin preferred because of higher levels obtained, roxithromycin, or azithromycin) with 6 grams of pyruvate given 1 hour prior to the antibiotic dose. In addition, 400 mg of Ibuprofen should be taken twice a day along with 1,200 mg of NAC twice a day. For those with severe reaction, low dose prednisone 5 mg per day. For those who get a severe reaction with the pyruvate/macrolide, 3-4 days of low dose prednisone could be tried. Also, using additional pyruvate (3-6 grams) for reaction should be tried.

For those that have a major side effect on the pyruvate/macrolide alone, I'd continue to treat with the macrolide alone until the side effects are manageable. For those that don't, I'd add doxycycline 100 mg twice a day with 6 grams of pyruvate 1 hour before. Continue the NAC and Ibuprofen.

After two weeks of doxycycline if all went well, I'd add metronidazoleⁱi 500mg twice a day with 6 grams of pyruvate before that. If a reaction is seen.

To the metronidazole, I'd then pulse it until the reactions were manageable.

If minimal reactions, I'd continue therapy for at least 1 year and then recheck titers. If titers were low, I'd add rifampin or rifabutin (preferably), using the rifamycin with pyruvate taken 1 hour before the rifamycin. If no reactions to this, I'd consider the therapy to be complete.

I would continue to monitor titers every several years. If the titers increased, I'd retreat with 6 months of clarithromycin or roxithromycin plus rifabutin plus pyruvate and ibuprofen. I'd continue the NAC for life.

For people on the existing CAP who are being switched:

For those on the current Doxycycline, Azithromycin, Metronidazole, and NAC protocol, my thoughts are that they should first switch from Azithromycin 250 MWF to Clarithromycin 500 mg twice a day (or Roxithromycin) and then add pyruvate

Dr. Stratton adds that Levaquin may be used instead of Clarithromycin for a short period (one month) as it has excellent activity for a short period of time. Clarithromycin = higher levels. Levoquin Both when combined with pyruvate theoretically will provide better killing.

___________________________________________________________

Wife with CFSⁱ/FM/REYNAULD'S 15YRS Lab positive for CPnⁱ/HHV7&11/EBVⁱ. Son 17yo with FM 3yrs- both on all supplementsⁱ since 8/08 Started CAPs per Strattons modification (clindy/pyruvate/doxyⁱ) started 11/17/08

LW,

I have a feeling that thread was removed as there was some doubt about the effectiveness of the pyruvate in making the protocol easier.   Another thread followed that one, that may be worth reading.

I'm not really the best person to ask as my level of understanding of Chemistry, microbiology and metabolism is very sketchy; there are better authorities on this site than I.   I am only concerned about the single antibiotic... Its ok for a short while but not for the length of the treatment.

But with your experience and researching skills I'm sure you will keep on top of things.

___________________________________________________________

Michèle (UK) GFAⁱ: Wheldon CAPⁱ 1st May 2006. Daily Doxyⁱ, Azi MWF, metroⁱ pulse.

LW, it is early here and I need to read your thoughts more fully but I want to make several comments for your thought process to consider.

1.  It seems that clindy was not what you meant, was it clarithromycin?  If so please correct your signature for future readers. 

I took a quick look at clindy in the Physician's Drug Handbook 12th edition yesterday.  CPnⁱ and spirocetes were not specifically mentioned by bacterial vaginosis, which I would think could include CTrⁱ could fall under that catigory.  My concern is that it may have untoward effects used long term as is needed for chronic persistent as opposed to acute infectionsⁱ. JMHO, just my humble opinion.

2.  JMHO is that many of us with unrelenting fatigue and FMSⁱ seem to be canaries and often need to ease into the CAPⁱ or many of us are layed out flat on the couch and in pain.

Some folks do quite ok with Levaquin and other Quinolones and fluoroquinolones are bactericidal drugs, initially the doxyⁱ and the macrolides are bacteriostatic in action at the starting amounts.  Some who do not do well with the initially strong effect can suffer severe cartilage and ligament repercussions.  Depends where the bacteria have taken up residence in any particular body, IMHOⁱ.   I would be cautious in their initial use. 

People have dropped the treatment because they simply will not chose to tolerate the quick imersion.   No not everyone but if you are hoping for buy in from you crew then ambling not sprinting from the onset may be a better consideration.

Are they both able to be laid low for several months?  Only you and they can know that.

My take on pyruvate is that it augments the abxⁱ when taken prior to it and perhaps helps with effects of the abxⁱ when taken after.   I began using it mid afternoon this past August, over a year after I started the Stratton Wheldon CAP.   We have had a few folks do well with the before and after approach and we have had folks become overwhelmed.    IMHO the basic Wheldon CAP introduced as outlined in that manner of progression is the safest, kindest, most cost effective for initial treatment.   

Please keep us up to day.   I recall your name from last year and it is good to know that folks actually get the imformation here, do their homework and research and come back!

Blessing to you LW.   Louise

___________________________________________________________

6-07WheldonCAP CFS20+yr

(11-29-07 started Cholestyramine HS PRNⁱ x 7d for porphyrin+endotoxinsⁱ removal)

Check out Louise's Blog at; http://www.cpnhelp.org/blog/louise for the details of my treatment adventure!

sorry so late to reply -you were right i meant Clarythromycin.  i'll change that. My wife had a real big response after about 6days on once daily biaxin/doxyⁱ with pyruvate before the dose. Cleared with tumeric/cinemet/advil/vit c in about 2days. My son had a similar response which lasted about a day at its worst but he has no complaint of pain in his legs or fatique the last 6 days just some blurry vision at distance( something that had improved earlier) i will maintain the once a day dosing for 30day before goind BIDⁱ.

___________________________________________________________

Wife with CFSⁱ/FM/REYNAULD'S 15YRS Lab positive for CPnⁱ/HHV7&11/EBVⁱ. Son 17yo with FM 3yrs- both on all supplementsⁱ since 8/08 Started CAPs per Strattons modification (clindy/pyruvate/doxyⁱ) started 11/17/08

sorry so late to reply -you were right i meant Clarythromycin.  i'll change that. My wife had a real big response after about 6days on once daily biaxin/doxyⁱ with pyruvate before the dose. Cleared with tumeric/cinemet/advil/vit c in about 2days. My son had a similar response which lasted about a day at its worst but he has no complaint of pain in his legs or fatique the last 6 days just some blurry vision at distance( something that had improved earlier) i will maintain the once a day dosing for 30day before going BIDⁱ.

___________________________________________________________

Wife with CFSⁱ/FM/REYNAULD'S 15YRS Lab positive for CPnⁱ/HHV7&11/EBVⁱ. Son 17yo with FM 3yrs- both on all supplementsⁱ since 8/08 Started CAPs per Strattons modification (clindy/pyruvate/doxyⁱ) started 11/17/08