Why do I feel so low when increasing NAC?
This is the second time I get depressed (that is a strong word) or very low a few days after increasing NACi. The first two-four days I get symtoms like joint-pain, sore throat, but then I get really tired and almost depressed. That is today. Last time it happened I didn't take any NAC at all the next day and the low-feeling disappeared. But I don't know if it was the right thing to do. Also my body have been much more swollen than usuall.
Do you think this a die-off reaction ? Can toxins from dead EBs do this? Depressed feeling and fluid accumulation? I have much more difficulties to tolerate a low mood than pain. And that constantly swollen feeling is very irritating.
I am sure the answer already is here somewhere here on cpnhelp but I don't have the energy to search for it.
Odhilda
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Yes Odhilda, the toxins are doing this and the best way to deal with toxins is to drink lots.....water, green tea, anything you like but not artificially sweetened stuff and move about as much as you can. It seems counter-intuitive to drink lots when you feel swollen but it works to get the stagnant fluid moving and out. Then once the toxins are out they won't be affecting your brain so the low feeling improves too. Maybe you could try backing down to the dose of NACi that you were tolerating before instead of stopping altogether, then when you feel better try for the bigger dose again.
Elinor ..... from England on CAPi, doxyi/roxi/tini for ME/CFSi/lyme borreliosis, positive Cpni and borrelia. Started Aug05, stopped Jan06, started again Sept 06.
Hey Odhilda,
The NACi does create die off reaction & it made me really tired. I had to have a "NAC Nap" in the beginning until I got used to it. If the reaction is too much to handle at the moment, you may want to decrease your intake for the time being.
Grace & Peace
Ruth
CFIDSi/ME, FMSi, IBSi, EBVi, Cpni, Babesia, insomnia (sleep- melatonini, GABA, tarazadone, temazepam, novocyclopine, allergy formula, 2 gm tryptophan), Natural HRT peri-M, NAC 2.5 gm, Doxyi 200 mg day pm, Azith 250 mg M/W/Fday
CFIDSi/ME, FMSi, MCS, IBSi, EBVi, CMV, Cpni, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplementsi+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyli/day-5 days<
It is not uncommonn for people to find it difficult to increase the dose of NACi, it can lead to a variety of different symptoms. I found it particularly difficult on my stomach and gut, but then these are the site of some of my major symptoms.
Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyli at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMSi Wheldon CAP 16th March 2006
Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.
Hi,
I had a similar reaction when I increased NACi from once to twice a day.
I read that Dr. Cheney cautions people about using NAC as it can induce depression.
I am going to limit NAC to 600mg once a day -- as long as even that doesn't bring on depressive feelings.
I know the difference between depressed feelings and feeling just down or some kind of reaction to toxins. Perhaps googling NAC might bring up more info or google Paul Cheney, MD who is a well known cfsi specialist might be informative. Hope this helps.
denise
63 year old woman who feels like 100! CFS since 1998. Main problem -- severe fatigue with "going into shock" feeling very often. Tested positive for CPN 3/07. Severe reaction to azithro (begun slowly in 5/07) - had to stop. No abxi yet --
63 year old woman feels like 80! CFSi since 1998. Severe fatigue and awful reverse sleep main symptoms. No Fibro. Tested positive for CPN 3/07. Severe reaction to azithro (begun slowly in 5/07) - stopped.
Thank you Denise, that is very interesting to hear! As you suggest, I think I will make a google on NACi and Paul Cheney further on.
"Odhilda" Diagnosed with chronic fatigue syndrom 1999 not able to work or study since 1993. Mekobalamin(B12) injections. Levaxine. Sweden is my home and Swedish my first language. NAC 700 mg.
"Odhilda" CFS, not able to work or study since 1993. Mekobalamin (B12) injections 10mg x12/month. Levothyroxine(T4). NACi 500-850. Started Doxyi Sept-07. Started Roxi Nov-07 first Metroi-pulse March-08. Swedish is my first language.
Hi Michele,
Have you heard of people having reactions of depression to NACi?? It occured with me -- I want to take NAC so will re-try it at 600mg and see what happens. I know it's not just the "blues" when it occurs. Perhaps I should try even slower intro -- say 600mg every other day? Yep, it's always something!
63 year old woman who feels like 100! CFSi since 1998. Main problem -- severe fatigue with "going into shock" feeling very often. Tested positive for CPN 3/07. Severe reaction to azithro (begun slowly in 5/07) - had to stop. No abxi yet --
63 year old woman feels like 80! CFSi since 1998. Severe fatigue and awful reverse sleep main symptoms. No Fibro. Tested positive for CPN 3/07. Severe reaction to azithro (begun slowly in 5/07) - stopped.
When I began the NACi the worst reaction I had at the time was I required a NAC nap daily for a few weeks.
CFIDSi/ME 25yrs, FMSi, IBSi, EBVi, Cpni, (insomnia - melatonini, GABA, tarazadone, temazepam, novocyclopine, allergy formula, 2 gm tryptophan), Natural HRT peri-M, NAC 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 250 mg M/W/Fday, 8-21-07 1st pulse 1 X 250 mg Metroi
CFIDSi/ME, FMSi, MCS, IBSi, EBVi, CMV, Cpni, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplementsi+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyli/day-5 days<
People have reported feeling depressed, but it is sometimes difficult if you are taking NACi at the same time as the ABXi to decide which substance is the culprit. For instance my stomach gets the worse of it when I take NAC and flagyli, more NAC more stomach problems, but equally more Flagyl more stomach problems. I have not dared increased both at the same time.
Michele (UK) GFAi: Wheldon CAP1st May 2006 . Daily Doxyi, Azi MWF, Flagyl at 400mg for 7 days prior to 5 day pulses at 1200mg three weeks cycle. Spokesperson for Ella, RRMSi Wheldon CAP 16th March 2006
Michèle (UK) GFAi: Wheldon CAPi 1st May 2006. Daily Doxyi, Azi MWF, metroi pulse.
start doxyi/azith 10/05 Start tinii 1/06 switching to flagyl 11/06 at full flagyl pulse. (1000mg x 5 days) Having trouble getting the Nac up from 600mg per day. Ldni since 2004 dxi: multiple sclerosisi edssi 7.2
Rica PPMSi EDSSi 6.7 at beginning - now 2. Began CAPi Sept, 2004 with Rifampin 150 mg 2xd, Doxyi 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith, cont. flagyl total 44 pulses NC USA
3/9 Symptoms returning. Began 5 abxi protocol 5/9 Rifampin 600, Amox 1000, Doxyi 200, MWF Azith 250, flagyli 1000 daily. Began Sept 04 PPMSi EDSSi 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan In for the duration.
start doxyi/azith 10/05 Start tinii 1/06 switching to flagyli 11/06 at full flagyl pulse. (1000mg x 5 days) Having trouble getting the Naci up from 600mg per day. Ldni since 2004 dxi: multiple sclerosisi edssi 7.2
kcapozza, I have been googling and I can't find it either. How much vitamin c are you taking and in what form?
"Odhilda" Diagnosed with chronic fatigue syndrom 1999 not able to work or study since 1993. Mekobalamin(B12) injections. Levaxine. Sweden is my home and Swedish my first language. NAC 1000 mg.
"Odhilda" CFS, not able to work or study since 1993. Mekobalamin (B12) injections 10mg x12/month. Levothyroxine(T4). NACi 500-850. Started Doxyi Sept-07. Started Roxi Nov-07 first Metroi-pulse March-08. Swedish is my first language.