When start with the 3rd Abx?

Submitted by claudiap on Wed, 2016-09-21 06:54

Hello all of you, I'm writing as I need your advice...I want to start with the 3rd Abx, but I' m not sure, when there is the right time for it. I started end of April with Doxy, some weeks later with Azi. Each time I felt a deterioration, so that in the meantime I cannot lift my right foot as is should be, going is very hard.

Now I wonder what will happen, when I start with the 3rd. I decided not to take Metro, but Tinidazol , here I got the info, that it should be "softer". I read so much in this forum that I sometimes do not know anything.

If I only take Doxy and Azi too long, is there the possibily that nothing happens any more with the CPn, I mean will they not be killed any more if the third Abx is not being taken? (Complicated - I hope you understand what I mean?!)

I thank you all for answers Smile


Hello Claudia, basically the longer you leave starting tinidazole, the easier you will find it.  I started after three months but only because I was getting no further reactions with the first two antibiotics.  When I did start, I did five days of full dose straght off but not many people manage that and some people don't even start until over a year.  The first two abx stop the C pn replicating, so you can take your time. 

When you do start, do it very gradually as it recommends both here and on David's site.  Never take the stuff for longer than you feel able because metronidizole and tinidizole are not pleasant to take.  Tinidazole tastes slightly better and made me rather less depressed but I was always glad to finish a pulse..............Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

It has been so long since I have been taking all five abx every day that I don't even remember what the third  one was.  Rifampin was first with me.  I then added flagyl and Doxy, then Amoxicillin and Azithromycin.  Rifampin was Sept 2004, I believe.  It was fairly easy at the beginning, but as I added the others it was harder, and by the time I was on all five, I would be knocked flat in about an hour.  At the beginning it would be for five to six hours and gradually decreased in severity and length until now, twelve years later, I am slowed down for several hours but not flattened.

I'm pretty sure I would have been dead ten years ago without this - certainly in a wheelchair with a feed tube.  I was already having trouble swallowing.


3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

So, you are planning your first pulse?  Yay!

You can start to pulse when you're no longer having reactions to the first two antibiotics.  It sounds like you aren't having any reactions now, so feel free to start.

As Sarah says, start slowly.  You are going to WORK UP TO five-day long pulses of metro.  You are not going to start with five full days.

Pick a time when you have a couple of days to 'recover', and hope you don't need any 'recovery' time. Cool

So, resolve to take one pill, or maybe two doses, and see how it goes.  (Like Sarah, I did the full five days' pulse the very first time, but some people can't handle that much, that soon.) 

Wait three or four weeks, then pulse again, maybe adding a day each time you pulse.  You'll be able to judge for yourself how much you can manage.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Sarah and Mack have given you good advice... All I'd add would be to have a serious look at Dr Stratton's idea of having pyruvate before the antibiotics... for me at least it helps - the pain changes to a less nasty type and I break into a sweat 1 hour after taking the antibiotics - but see that as good as I feel my immune system is doing more killing off... 

Started NAC Sept'14... 100mg Doxy Dec'14...  Roxi 13Dec '14 Supplements...


Thank you all of you for your answers. It’s a bit strange: I askekd  whether I have to expect another deterioration (probably, as this is a sign that the killers are killed themselves…)  when I start the 3rd Abx  and – I feel terrible without taking the 3rd…. I cannot stretch my legs at night – quite painful, my right foot doesn´t like to work and can be lift less than 1 week before, when I want to go, I cannot bend my leg – it´s like a stic!  My right hand feels numb and weak – I could scream and shout, be angry furious….. aaaaahh! Tell me, is this possible to feel like that without having changed anything? I am desperately that the MS is working, but I hope of course that this is a side effect of my Abxs.? Should I increase any supplements to improve?

I take NAC 1200 , Vit. C 2000 mg(2x1000), 1x Alpha-Lipon 600 mg, 1x B12 1000 µg, Probiotics, I fill up my Vit D3,


I feel terrible, and hope you have some advice for me!? Thank you in advance.

Katman – why did you take 5 Abxs a day? I never read about this?


Regard to all of you


Claudia, it is very difficult to answer this because everyone is so different.  For instance, pain has never played a big part with my MS except for once, after my third pulse and then the pain was like nothing I had ever experienced before.  Luckily it only lasted a few weeks and I guess it was part of the killing process.  The pain was in my previously nearly paralyzed right arm and has never returned although it did leave my arm rather weak for a few weeks.

I started the third antibiotic after three months and it went comparitively smoothly after that time but some people take much longer to be able to start and when they do, just one tablet is enough.  Generally speaking though, the longer you leave it the easier it will be. 

There are all sorts of supplements listed here in various places which you could try, but whether they will improve things or not, I can't say.  Your supplement list seems reasonable, but I did and still do take at least 5000 mcg of B12 a day, usually twice that and 5000 iu of D3.  I think probiotics can only be beneficial so long as they are spaced well apart from the antibiotics......................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.