Wheldon Protocol - Any Advice?



I am seeing my doctor in two weeks, but I wanted to ask if any of the experts here have advice that I might suggest to my doc.  I have Cpn and EBV diagnosed via blood tests 3 months ago.  My doctor has me on the Wheldon protocol.

In December he started me on Monocycline + Azythromycin and all was good until we added the second 100 mg of Mino and then my stomach couldn't handle it.  In January he switched me to Doxy+Azythromycin and all was good until we added the second 100 mg of Doxy about a week ago and now my stomach can't handle it.  I have tried taking the 2 doses 12 hours apart and still no help.

So my questions to the experts:

(1) If I can only take 100 mgs instead of 200 mgs, is doxy or minocycline any preferable?  I know mino is supposedly stronger in some ways in crossing the blood brain barrier.

(2) Is there a different antibiotic all together that might be better to combine with azythromycin if I can't take doxy or mino?

Thanks for your help,


Hi Sue

My Doxy is ALWAYS a problem if I don't drink enough water.  It will never stay down unless I drink at least ten or twelve ounces.  In the morning when I take Doxy, Amoxicillin, Rifampin, and flagyl together, I drink at least that much. In the evening when I take Doxy, Amoxicillin, Azithromycin, and flagyl, I can have food in addition.  (I wake up in the middle of the night to take my other Rifampin and thyroid.)  

Keep working - this is a challenge.  I'm sure you will find your way.  


3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

You need to take 200mg of doxy, so try as Rica suggests and/or also have some Greek yoghurt with it to line your stomach......................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.


Behind you questions you are wondering "Will I ever get there?"  Yeah, we all wonder that; we all wonder whether the treatment will not work for us or will not be suitable.  I worried that perhaps I'd get left behind or that I might become alergic to these antibiotics.

You have tried to take the reccomended amount of doxy and you couldn't manage it ... so you feel a little despair.  All our bodies work differently and we all suffer differently and there will also be a different pattern of recovery for each of us.  Cast aside any despair and recognise that you are already fighting and winning in this battle (and that's despite the fact that you are not yet firing all guns).  Hey, take a look at this thread by one of your fellow newbie CPners:


Yeah, she was doing pretty good but has taken a step back over the last week or so.

I remember when I was on my 2nd day of doxy last May; I took it almost on an empty stomach: big, big mistake.

Ok, you take one doxy alright ... but then if you try to pop a second straight afterwards, the whole thing goes wobbley, right?  So how about you try the same thing eight to ten hours later with plenty of food and lots of drink?  Wanna give it a go?  Even if not, you are still on the right road.  Compare what you're doing to those that are just sitting doing nothing.

Hey, you are doing just fine and you will win through in the end.

Good luck,


“Don't believe everything you read on the internet.”

―    Abraham Lincoln

HI there,

I used to be on a low carb diet - but now I need to take some carbs with my antibiotics.  I also need to nibble on something like a granola bar for about an hour afterwards.  By doing this I am now able to keep all my antibiotics down.

Good luck!