Vitamin D Induction of the Human Antimicrobial Peptide Cathelicidin in the Urinary Bladder
Swedish researchers investigate that vitamin D supplementation is useful from preventative reasons for UTI.
"In light of the emerging resistance to antibiotics used against UTI , new treatment strategies are needed. Our data suggest that vitamin D can stimulate an increased production of the antimicrobial peptide cathelicidin. By inducing and activating cathelicidin with vitamin D, a local rather than a systemic effect can be achieved. This could offer selective and site-specific treatment of pathogens without perturbing commensal microbes elsewhere in the body. Likewise, systemic effects of 25D3 treatment secondary to cathelicidin induction seem unlikely. This could make 25D3 an effective and safe way of activating the endogenous antimicrobial response locally at the site of infection. Determining the vitamin D status of individuals with a history of UTI may be of importance to evaluate their ability to fend off intruding bacteria. Supplementation to restore proper vitamin D levels may therefore help preparing the bladder epithelium to mount a stronger and faster immune response once bacteria enter the bladder"