J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):793-8. Epub 2007 Jan 12.Click here to read Links
Vitamin D in the treatment of pulmonary tuberculosis.
* Martineau AR,
* Honecker FU,
* Wilkinson RJ,
* Griffiths CJ.
Centre for Health Sciences, Institute of Health Sciences Education, Barts and The London School of Medicine and Dentistry, London E1 2AT, United Kingdom. firstname.lastname@example.org
Vitamin D was used to treat tuberculosis in the pre-antibiotic era. New insights into the immunomodulatory properties of 1alpha,25-dihydroxy-vitamin D have rekindled interest in vitamin D as an adjunct to antituberculous therapy. We describe the historical use of vitamin D in tuberculosis treatment; discuss the mechanisms by which it may modulate host response to infection with Mycobacterium tuberculosis; and review three clinical trials and ten case series in which vitamin D has been used in the treatment of pulmonary tuberculosis.
PMID: 17223549 [PubMed - indexed for MEDLINE
This is important work considering the difficulty with resistant strains of TB. Understanding adjucts and how best to maximize what we can do to improve the body's ability to get rid of the germ is critical.