Cpnhelp.org

Studies suggest that Vitamin Dⁱ is important for nervous system function and repair.   Some important studies include:

• Vitamin D and the Nervous System

The above article contains an amazingly complete and fairly easy to read review of the known actions of Vitamin D in the body, including very good explanations of the known pathways.   The following section is particularly relevant:

Section 5.2 Effects of Vitamin D on the Nervous System - this section, I believe, is a must read for those with CNSⁱ issues related to Cpnⁱ.  Some points of interest:

• Vit D "participates in modulation of CNS detoxification pathways through regulation of y-Glutamyl transpeptidase, an enzyme which up-regulates the glutathione pool and reduces the production of reactive nitrogen species in astrocytes"
• Vit D "may inhibit the synthesis of inducible nitric oxide synthase (iNOS), an enzyme which is produces in response to inflammatory stimuli and have harmful effexts on the CNS"
• Vit D "may protect the structure and integrity of neurons through neurotrophin (NT) synthesis and nerve growth factor (NGF)"

• Vitamin D2 potentiates axon regeneration.

• Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes.

• New clues about vitamin D functions in the nervous system.

• Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2)-adrenoceptor agonists.

• A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.

• 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro.

• Effect of calcitriol in combination with corticosterone, interleukin-1beta, and transforming growth factor-beta1 on nerve growth factor secretion in an astroglial cell line.

More studies along these lines from as early as 1991:

• 1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells.

• MC903, an analogue of 1,25-dihydroxyvitamin D3, increases the synthesis of nerve growth factor.

• 1,25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis