Vitamin D3, Defensins, and Infection

 

Studies seem to suggest that Vitamin D3 plays an important role in production of  Defensins<, just is it apparently does with the more widely discussed antimicrobial peptides, Cathelicidins (LL-37<):

 

While less discussed than their antimicrobial "cousins", cathelicidins, studies suggest that Alpha and Beta Defensins also play an important role in host defense.   Here are a few such studies:

 

Alpha Defensins (also knowns as Neutrophil Defensins):

 

Beta Defensins:

 

 



Here's an excellent article on the various currently identified defensins and their molecular mechanisms of action:

 

 

 

Studies suggest that in addition to their antimicrobial effects, defensins may also play an important role in regulating immunei responses and inflammationi, as well as in wound repair: