Vitamin D and Nervous System Repair
Interesting:
Vitamin Di(2) Potentiates Axon Regeneration. Chabas JF, Alluin O, Rao G, Garcia S, Lavaut MN, Risso JJ, Legre R, Magalon G, Khrestchatisky M, Marqueste T, Decherchi P, Feron F.
Neurobiologie des Interactions Cellulaires et Neurophysiopathologie (CNRS UMR 6184), Université de la Méditerranée (Aix-Marseille II), Faculté de Médecine Nord, Institut Fédératif de Recherche Jean Roche (IFR11), Marseille, France., Services de Chirurgie de la Main, Chirurgie Plastique et Réparatrice des Membres, Assistance Publique, Hopitaux de Marseille, Marseille, France.
Abstract To date, the use of autograft tissue remains the "gold standard" technique for repairing transected peripheral nerves. However, the recovery is suboptimal, and neuroactive molecules are required. In the current study, we focused our attention on vitamin D, an FDA-approved molecule whose neuroprotective and neurotrophic actions are increasingly recognized. We assessed the therapeutic potential of ergocalciferol-the plant-derived form of vitamin D, named vitamin D(2)-in a rat model of peripheral nerve injury and repair. The left peroneal nerve was cut out on a length of 10 mm and immediately autografted in an inverted position. After surgery, animals were treated with ergocalciferol (100 IU/kg/day) and compared to untreated animals. Functional recovery of hindlimb was measured weekly, during 10 weeks post-surgery, using a walking track apparatus and a numerical camcorder. At the end of this period, motor and sensitive responses of the regenerated axons were calculated and histological analysis was performed. We observed that vitamin D(2) significantly (i) increased axogenesis and axon diameter; (ii) improved the responses of sensory neurons to metabolites such as KCl and lactic acid; and (iii) induced a fast-to-slow fiber type transition of the Tibialis anterior muscle. In addition, functional recovery was not impaired by vitamin D supplementation. Altogether, these data indicate that vitamin D potentiates axon regeneration. Pharmacological studies with various concentrations of the two forms of vitamin D (ergocalciferol vs. cholecalciferol) are now required before recommending this molecule as a potential supplemental therapeutic approach following nerve injury.
PMID: 18986226 [PubMed - as supplied by publisher
Vitamin D(2) Potentiates Axon Regeneration.
- Login or register to post comments
- Email this page
- Printer-friendly version
CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral
Stratton/Wheldon protocol 02/2006 - 10/11 for CFSi and many problems 30 years
Thanks for posting this Red. And what is all over the news this week? The study on breast cancer and D where the researchers used 400 iu.and got no positive results. Duh.........
Here it is:
http://tinyurl.com/554vgm
Raven
Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath
Hi Raven,
Kind of crazy, isn't it?
Meanwhile, more informed (IMHOi) researchers continue their work. Here's an interesting recommendation from Dr Vieth and a panel of experts who have submitted a warning about the toxicity of Cod Liver Oil in the current edition of the Annals of Otology, Rhinology & Laryngology:
"In addition to warning about the consumption of cod liver oil, the above experts recommended healthy children take 1,000 IU/day of vitamin Di for every 25 pounds of body weight. In some cases this is more than ten times current recommendations for children by the government and professional organizations. "
Medical News today: Dangers of Cod Liver Oil
Treatment for Rosaceai
More on Vit D3 and its effects on the nervous system:
New clues about vitamin D functions in the nervous system.
Pharmacological modulation of nerve growth factor synthesis: a mechanistic comparison of vitamin D receptor and beta(2)-adrenoceptor agonists.
A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.
1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro.
Effect of calcitriol in combination with corticosterone, interleukin-1beta, and transforming growth factor-beta1 on nerve growth factor secretion in an astroglial cell line.
Treatment for Rosaceai
Red, what a fabulous paper! Thank you so much for posting it. It is great news
Raven as for the paper with the 400IU, such "researchers" ought to be laughing stocks. It is patently absurd for them to not take the time to understand current research and build on that rather than doing something stupid like wasting money on a 400 IU study. The choice of 400IU is totally random obviously based on the old RDA which as been proven inadequate. And these people are the hope of patients everywhere??? God help us all
More studies from as early as 1991:
1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells.
MC903, an analogue of 1,25-dihydroxyvitamin D3, increases the synthesis of nerve growth factor.
1,25-Dihydroxyvitamin D3 is a potent inducer of nerve growth factor synthesis
I know I sound like a broken record, and I'm certainly no expert, but have you taken your Vit D3 today? If we use the recommendations from above for children from the panel of experts, amounts of 1,000IU for each 25 pounds of body weight and even more may be required if you are ill (or more specifically, IMHOi, if Vit D3 is being used in larger amounts by your body to combat infectionsi, rebuild bone loss, regenerate nerves, etc)...
Treatment for Rosaceai
Wow, fantastic article, Red, thank you so much! (And no, you don't sound like a broken record, and even if you did please don't stop!)
Also - I had not heard of the Vit D link with regard to autism ("the group recommended that "children with chronic illness such as autism, diabetes, ... may need to take even more vitamin Di"). I have a friend whose grandson has some form of autism, I will send this information along to her.
And unfortunately, no I have not taken my Vitamin D3 today but thanks to you I am going to be much more faithful about taking it, as well as ramping up the amount to match body weight plus compensate for illness!
Kelly
Diagnosed FMSi Feb '07. 2x/day: 600 mg NACi, 100 mg Doxyi, 500 mg Amoxicillini, 2000 iu Vit. D. 450 mg Valcyte. 250 mg Azi M/W/F. 500 mg 375 mg Flagyli pulses every 3-4 weeks. Started CAPi June '07.
Has anyone found that they had an immediate reaction to taking vitamin D3? I talked with a patient who took 1000 iu of D3 and had an anxiety attack. I would be interested to know if there is any rationale for this reaction. Has anyone on this message board had any immediate bad reaction to vitamin D?
Thanks,
Paula
Paula Carnes
Paula, its certainly not unusual for toxic people to react immediately to vitamin Di. An anxiety attack may be porphyriai linked, or just a generalised die-off effect. I only tend to get immediate reactions to D if I up my dose suddenly, in which case I get an endotoxini/sickness type reaction as though my body is fighting something.
Red, are all of these articles included in the Vitamin Di page where you are keeping such links gathered together?
I am just wondering as this is an older forum topic.
Thanks for keeping the links so nicely gathered together. Louise
Treatment for Rosaceai
Almost immediate die off reactions from summer sun exposure during my first two years of CAPi--at the time I was taking about 4000iu as a supplement. Days outdoors in the sun---took no supplemental D at all. It took about 30 minutes to 1 hour for the reaction to occur. Now it doesn't happen with sun or supplementsi.
I ramped up to 10,000 iu at the beginning of December since the weather was pretty stormy--no sunshine.I also felt that since I have both infectionsi and a mutation in one of my vitamin Di receptors (VDR FOK)it might be a wise thing to do.
My blood tests are now normal. They were rock bottom--can't recall the numbers but very low.
Red, thanks for posting this article about nerve regeneration. The miracles of D just keep on coming....
Raven
Feeling 98% well-going for 100. Very low test for Cpni. CAPi since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NACi,BHRT, MethyB12 FIRi Sauna. 1-18-11 begin new treatment plan with naturopath
5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tinii pulses,100 mg diflucan, 4.5 ldni; Wheldon protocol for MSi April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.
CAPi for Cpni 11/04. Dxi: 25+yrs CFSi & FMSi. Currently: 250 aithromycin mwf, doxycycline 100mg BIDi, restarted Tinii pulses; Vit D2000 units, T4 & T3, 6mg Iodoral
Hi Chris,
Vit D3 is very powerful stuff as Jim says. The good news is that Vit D3 is stored in the body. So if you need to take a little break, start again at a lower dose, and then work your way up slowly, no harm is done (and you don't need to worry about resistance, etc).
Hang in there. I hope you feel better soon!
Treatment for Rosaceai
Red, agreed on the ramp-up. I've just gotten two of my friends to start vitamin D3 and both wanted to start at my level, which is 8,000 to 10,000iu a day. I bought them bottles containing 1000iu gels and told each of them 'no more than one a day'.
Well, one of them has JimK's problem; why do it if you can't OVERdo it?
He took one, then two the next day, then three the third day. Within a week, he feels crummy. Surprise. As a result, he wanted to swear of D completely.
We had a talk last night (of the two of them, he's the one I am SURE has a cpni infection) and he now seems to understand why he has to move slowly. He's taking nothing today and will start again with only one pill tomorrow. People don't realize one can't jump from zero to sixty mph without taking a chance on a crash!
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
Hi Mac,
I've seen the same thing with people I've recommended Vit D3 to. One of the reasons seems to be that for the first couple of days, people seem to notice that they feel much better. This only encourages them to move too quickly. And unfortunately as you know, after only a few days at even a fairly low dose, once Vit D levels start to build, this sense of feeling better is often (but not always) replaced by feeling much worse.
Interestingly, about 50% of the people who have taking Vit D3 (and just Vit D3) after much badgering on my part, notice heavy sinus involvement @ 4 - 6 weeks into an only 2000iu or so dose. It presents with symptoms of a very bad sinus infection and even lower respiratory involvement and can last for 2-3 weeks. I try to explain that this could happen when they first start Vit D3 (and at each stage of ramp-up), but almost everyone who gets it is surprised enough by the first reaction that they often want to quit. It takes a surprisingly large amount of hand-holding (and many discussions about cathelicidins, defensins and die-off) to get them through this, but most do seem to make it through it and then spread the word to other friends. Still some are very hesitant to move up from lower levels...
Most of my friends and family now though talk about their levels of Vit D3 and "the die-off" all the time though. And many are now even teaching their doctors about the benefits of Vit D3. Kind of amusing. But very encouraging...
Treatment for Rosaceai
Red, I have many of my friends on Vitamin Di now, some at 4000iu a day or more, but most of them on lower amounts because they seem incapable of taking more than recommended on the bottle. I was talking to one such friend on Friday and told him that since he was finding benefits with his itchy skin already, he should try 4000iu. I'm waiting for the fireworks here, lest he decides just to stop like Mack's friend............Sarah
An Itinerary in Light and Shadow
Hi Sarah,
Glad to hear you've managed to convince at least some of your friends to use 4000iu a day or more! And even lower doses are probably better than nothing!
For those who suffer from the "take one a day per the instructions on the bottle" syndrome, have them buy one of these
:
http://www.vitacost.com/NSI-Vitamin-D3-4000-IU-300-Softgels
Treatment for Rosaceai
Already thought of that since it is what I use myself! The other trouble is getting people to buy from overseas, though, but I can suggest buying some for them myself, if I know they will pay me. The itchy skin fellow will, because he used to be my boss and does everything I tell him!............Sarah
An Itinerary in Light and Shadow
Treatment for Rosaceai
best, John
RRMSi/EDSSi was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
naci 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day