27 Apr 2018

Vitamin C and NAC


Someone sent me this article about Vitamin C and NAC. Can our science folks take a look and see
if this information is suspect?



I also found this article on NAC and endotoxinhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9436612&dopt=Abstract Raven 

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Note that this first study is on an N=14, a very small grouping to be making any speculative conclusions from. This is only of interest if it should be a repeated finding. As it stands, there is such an overwhelming number of studies showing antioxidant and other useful effects of these supplements, the following study you cite is an example especially in endotoxin diseases such as Cpn, that I would hold this aside until further findings.

On Wheldon/Stratton protocol for Cpn in CFS/FMS since December 2004.

The information in the first article is sound enough as far as it goes, yet they do not differentiate between what was obviously a severe crush of the bicep muscle and other things inflammatory.  What they did to these people will have let large amounts of free iron loose in haemo and myoglobins.  It isn't the same as having a CPn infection.  Besides which they say that the treatment was damaging, but they do not say how, just that there was release of free iron.  I have been taking about three times the amount of vitamin C used in this experiment for at least a couple of years, and more than twice the mount of NAC for about six months at least, yet I show no signs of damage.  In fact my hair has grown by more than half an inch a month this year and my fingernails seem to grow enormously just overnight.  That doesn't sound like I am being harmed.  I think the second paper is far more relevant to people with our infection.........Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.


Looking at the abstract of the first study it seems well-mounted and well-reasoned, and the study gave results other than those which were hypothesised, which is always more interesting. If I read the abstract rightly (and it's always risky to read an abstract alone) the authors studied bruised muscle, where there would have been a lot of degenerating myoglobin from dying muscle and haemoglobin from extravasated blood (think of how bruises change colour) and thus a lot of free extracellular iron. This would seem to be a very different case from that of cpn infection where free iron is not - as far as I know - a feature. In fact iron-depletion seems to be a well-established macrophage strategy against cpn infection. There's a vast difference between the situation within cells and in the extracellular millieu around damaged cells. But these are only tentative thoughts.

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. No medication now. Morning BP typically 110/75]