Submitted by mrhodes40 on Sat, 2007-06-02 11:00

Georgian Med News. 2007 Apr;(145):58-62. [The role of endothelial dysfunction and Chlamydia pneumoniae infection in patients with ischemic stroke.] [Article in Russian] * Devidze E, * Sanikidze T, * Samadashvili D. Department of Neurology, Tbilisi State Medical University. The research purposed to investigate the Chlamydia Pneuminiae infection in patients with ischemic stroke and to establish the correlation with elevated C. pneumoniea antibody titers and endothelial dysfunction. 72 patients with acute ischemic stroke, aged 45 to 75 (45 male and 32 female) have been researched. Patients were grouped according to etiology of stroke (based on International classification TOAST). The blood was taken in 48 hours from stroke onset. ELISA method was applied to detect the antibodies against C. Pneumoniae. The intima-media thickness of the common carotid artery were assessed by B-mode ultrasonography (Acuson128XP/10) with a 7.5-MHz linear-array transducer. Flow-mediated dilatation (FMD) of the brachial artery were measured from high-resolution, 2-dimensional ultrasound images obtained by an ultrasound machine with a 7.5-MHz linear-array transducer. Free NO were examined by Electron Paramagnetic Resonance (EPR) method in blood. Control consisted with 15 healthy volunteers. Multivariate logistic regression showed a significant positive correlation between blood elevated titers of IgA and IgG of stroke patients and the intima-media thickness of the carotid artery (correlation coefficient by Pearson r = 0,31; p<0,05, r = 0,27; p<0,05). On multiple regression analysis, percent FMD showed a significant negative correlation with the intima-media thickness of the common carotid artery (r= -0,57, p<0,05), positive correlation between NO and the intima-media thickness of the carotid artery (r= 0,72, p<0,05). Association between antibody seropositivity for C. pneumoniae and increase of the IMT in the common carotid artery indicates persistent chronic infection in patients with ischemic stroke. Correlation between NO, an increase of the IMT in the common carotid and artery flow-mediated dilation of brachial artery indicates on the participation of NO in development of endothelial dysfunction and its significant role in pathogenesis of ischemic stroke. These findings support the concept that NO-inducible endothelial dysfunction is related to atherogenesis. PMID: 17525503 [PubMed - in process] Intimal medial thickness is a measure of atherosclerosis.  Ultrasound is used and it literally checks the carotid artery to see  how thick it has become.  The thicker it is the more risk of cardiac and stroke events.It is incredible that in spite of the vast amount of research along these lines the role of CPn in these events is still debated and there are still no effective (CAPs) therapies suggested for these patients.  Oddly, no one seems to be designing and researching a combination protocol based on the lifecycle of CPn and the known research there, though there continues to be short course mono therapy research (ie azithromycin) coming out regularly that shows no statistically significant effect.   It was true on day one of this website that the CDC had already designated CPn as an emerging pathogen in atherosclerosis, and it remains so to this day.  Thank goodness for the work at VU and the public exposure of that material here. 

Comments

D W

Marie,Thanks for posting this. It becomes personal; I really don't know what would have become of both Sarah and I had we not found the Vanderbilt studies. D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. Now on intermittent treatment. BP this morning 112/80]

D W - [Myalgia and hypertension (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazole. No medication now. Morning BP typically 110/75]

David, I have to add my thanks to so many here, beginning with my sister, Barbara, who found you and Sarah, who in their turn had the great fortune to find Charles Stratton, M.D. and to Marie, who continues virtually behind the scenes to locate these wonders and put them here for us to see, and never-to-be-forgotten Jim who has brought us all together. Thanks is not enough for you all.

 Rica PPMS  EDSS 6.7 at beginning - now 2.  Began CAP Sept, 2004 with Rifampin 150 mg 2xd, Doxy 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith,  cont. flagyl  total 42 pulses NC USA

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Very interesting abstract, Marie. After both attacks I had MRIs done. Both the examining radiologists wrote "sub acute ischemic attack" as possible cause both times.One neurologist even send me for an ultrasound of the carotid artery as he spotted some narrowing on the MRI of my neck. The results came back mild to moderate narrowing. This is the same guy who vehmently insisted I had a blood flow problem, not MS.
Let's just hope and pray that the medical profession gets a clue that all this is related. MS is a vascular disease and CPN LPS affects how our immune system functions. The more I read this stuff the closer I feel to having a small grasp of the complex dysfunction this infection engenders.
Raven
CAP since 8-05 for Cpn and Mycoplasma P. for MS and/or CFS

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

DW, and the VU work would have been invisible to most of us without you two, the world is a different place because of each of us. Raven, I, like you, continue to feel the tickle of ever more similarities and understandings falling into place and adding up. It is a fun journey.
marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5. Currently on: Doxy 200, Azith 3x week, Tini cont. since April '07, all supplements.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro