(Editors note: This is a report by Ella's mother Michele, a very active contributor to www.cpnhelp.org and user of the protocol herself. They began the CAP in the crisis of Ella's rapid deterioration and the change since then is quite remarkable though the story is far from over. It illustrates well the judicious use of steroids to manage inflammatory symptoms while slowly ramping up on the CAP. Most of us have followed Ella's progress with enthusiasm and bated breath. She's kind of become a mascot for many of us more "mature" types, symbolic of the restoration of vigorous life were this treatment started when we were younger! We will add to this update as her treatment progresses.)
In a casual email correspondence, David Wheldon was asked if he would speculate on the possiblity of using steroids along with the CPn treatment in MS to allevaite some of the psuedo exacerbations as some people have a noticable loss of function, particularly during flagyl pulses. His reply is below:
I think that's a very pertinent question, and I'm not sure of the answer. It's very complex and very individual.
I believe that you can get real relapses during first six months of antibiotic treatment - maybe more, because the antibodies to chlamydial hsp60 will still be there. But the likelihood of relapse is less, because you won't get a fresh cpn respiratory infection while taking antibiotics. These are a major cause of relapse, probably through the production of gamma-IFN. The second commonest cause of relapse, again through gamma-IFN, is influenza. But this might be mitigated by N-acetyl cysteine supplementation.
David Wheldon and Dr A were asked about the reason that steroids and immunosuppressants do not cause CPN to go out of control in the case of MS. If people with MS actually have CPn, why are steroids or things like tysabri apparently helpful? Why do they not make people worse? answer follows:
DR A's response (the MD who is close to the VU work who is expert)
As far as steroids are concerned, the cellular immune system isnâ€™t very effective against C. pneumoniae infections (The C. pneumoniae can infect every cell in the cellular immune system.). Therefore, interfering with the cellular immune system ( by giving something like steroids or suppression of the immune system ed.) would be predicted to have little to do with making the disease worse â€“ and might make the symptoms better if the symptoms were related to inflammation.