Immune system

Oral Bacteria Linked to Uterine Infections and Preterm Birth

Submitted by Jim K on Fri, 2006-04-07 07:15

While this is not Cpn, I felt it was an important related finding as it demonstrates infectious bacterial source behind a previously overlooked cause in a phenomena (look at the Cpn & Animal materials on our site to appreciate how much Cpn could be linked to spontaneous abortions and miscarraige). It also suggests that, like Cpn, blood findings are not especially useful to detect infection. In this case the researcher notes:

"The bacteria were not detected in the patient's blood, but they had likely been cleared from the blood by the immune system before they could be detected," Dr. Han said.

Many relevant parallels."The study is an eye-opener," Dr. Han said. "It shows that oral bacteria can get into the uterus."       bacterium genus Bergeyella      Ureaplasma urealyticum       Mycoplasma hominisOral Bacteria Linked to Uterine Infections and Preterm Birth By Jeff Minerd, MedPage Today Staff WriterReviewed by Zalman S. Agus, MD; Emeritus Professor at the University of Pennsylvania School of Medicine. MedPage Today - Little Falls,NJ,USA - April 06, 2006, April 6 - The first hard evidence has been uncovered that bacteria in the mouth may find their way to the uterus, causing uterine infections that can lead to preterm birth in pregnant women. A newly discovered and as yet unnamed species of the bacterium genus Bergeyella was found in the mouth and amniotic fluid of a woman with a uterine infection who gave birth prematurely (24 weeks), reported microbiologist Yiping W. Han, Ph.D., of Case Western Reserve here. However, the bacterium was not detected in a vaginal swab, as might be expected. The finding confirmed what some scientists have suspected, that intrauterine infections don't always "ascend" from the genital tract but can "descend" from the oral cavity, Dr. Han and colleagues said in the April issue of the Journal of Clinical Microbiology. The study included 19 pregnant women undergoing transabdominal amniocentesis because of preterm labor or threatened preterm labor. Amniotic fluid, blood samples, vaginal swabs, and oral swabs were collected from each woman and analyzed for bacterial DNA via polymerase chain reaction (PCR) and nucleotide sequencing. The species of Bergeyella was detected in the mouths of all 14 women tested, but in the amniotic fluid of only one patient. This woman had been diagnosed with a uterine infection based on an elevated white blood cell count and a low glucose level in the amniotic fluid. She went into labor, induced because of the infection, and delivered her baby at 24 weeks' gestation. Subsequent analysis of her placenta revealed severe and diffused chorioamnionitis and fetal vasculitis involving the umbilical cord and chorionic plate, which was the presumed cause of her preterm labor. "Intrauterine infection with Bergeyella has never been reported before. Where could the bacteria come from?" the investigators asked. Because the bacteria were not detected in the vaginal tract, the investigators hypothesized they were transmitted to the uterus from the mouth via the bloodstream. The bacteria were not detected in the patient's blood, but they had likely been cleared from the blood by the immune system before they could be detected, Dr. Han said. Although periodontal disease has been implicated in preterm birth, the patient showed no evidence of periodontal disease, the researchers noted. "The study is an eye-opener," Dr. Han said. "It shows that oral bacteria can get into the uterus." The study also suggested that more than the usual bacterial suspects may be responsible for uterine infection and resulting preterm birth, Dr. Han added. The usual suspects are known vaginal flora such as Ureaplasma urealyticum or Mycoplasma hominis. But Bergeyella, a little-known, rod-shaped, Gram-negative bacteria associated with dog and cat bite wounds, had not been thought to be an important component of the oral or vaginal flora. One reason Bergeyella may have been overlooked previously is that it is difficult to grow in culture. As much as 60% to 70% of oral bacteria can not be detected by growing on culture. The current study detected Bergeyella because it used PCR amplification of bacterial DNA rather than traditional culturing techniques, Dr. Han said. While suggestive, the study's findings do not yet support routine analysis of pregnant women's oral or vaginal flora to identify those who may be at risk for uterine infection, Dr. Han said. "That is the question we want to ask now," she said. Her research is examining whether particular components or oral or vaginal flora are associated with increased risk for uterine infection or preterm birth. The mother and baby from the study are healthy and doing well, Dr. Han said. ###--------------------------------------------MedPage Today Action Points:   Explain to patients that while suggestive, the study's findings do not support routine analysis of pregnant women's oral or vaginal flora to identify those who may be at risk for uterine infection --------------------------------------------Primary source:  Journal of Clinical Microbiology--------------------------------------------Source reference:   Yiping Han et al. Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth. Journal of Clinical Microbiology 2006; 44:1475-1483. --------------------------------------------© 2004-6 MedPage Today, LLC. All Rights Reserved.

INH and Clearing Cpn from immune cells

Submitted by Jim K on Sun, 2006-01-22 20:05

Looking again at the patent materials and having an interest particularly in their discovery of INH as an antichlamydial agent I selected this excerpt because of it's importance in restoring immune system functioning in those of us who have been immuno-compromised by Cpn. My daughter, for example, with terrible CFS/FM, gets every virus which happens by and always gets a worse case of it. Prior to treatment, I also got colds frequently. Cpn infects macrophages and monocytes, rendering these infected immune cells less functional. If this is a predominant site of one's infection, then it stands to reason that your immune system sucks! Or, more accurately, is being sucked on... because Cpn functions parasitically by stealing the mitochondrial energy of the cells it infects. I have highlighted and underlined some critical ideas in this excerpt. Thanks to Chuck Stratton, et al for your brilliant and underappreciated discoveries:

The immune system, atherosclerosis and persisting infection

Submitted by mrhodes40 on Tue, 2005-10-18 16:15

Vestn Ross Akad Med Nauk. 2005;(2):17-22. Related Articles, Links

[The immune system, atherosclerosis and persisting infection]

[Article in Russian]

Pigarevskii PV, Mal'tseva SV, Seliverstova VG.

The paper demonstrates that lymph nodes situated in the vicinity of magistral blood vessels are the source of immune and inflammatory response to LDL as the main pathogenetic factor in atherosclerosis. The activation of T-cell-mediated immunity takes place in them at the very early stages of the disease, resulting in forming of CD4+T-lymphocytes, activated mononuclear cells and immunostabilizing B-lymphocytes. The cell changes in lymph nodes correlate with the severity of atherosclerotic lesions in the vessel intima and closely reflect the peculiarities of immune inflammation development in fatty streaks and atherosclerotic plaques in human atherogenesis. A paradoxical reaction was observed in cases with Chlamydia pneumoniae found in the wall of aorta and paraaortal lymph nodes. No evident immune response on the part of immunocompetent cells took place, but, on the contrary, the function of mononuclear cells, including T-lymphocytes, was suppressed. This phenomenon may be explained by the fact that intracellular localization of Chlamydia pneumoniae hides it from immune system control or by the possible microorganism capability of direct immunosuppressive influence on lymphoid cells both in the blood vessel wall and in regional lymph nodes.