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Immune complex produced by the body when exposed to a foreign substance or bacteria

Jim’s Story- Chlamydia Pneumoniae and Chronic Fatigue/Fibromyalgia

The Tunnel of Illness

I want to update my story on the front end so readers know even before reading the "agony post" how much benefit I've gotten from the treatment. It is August 26th, 2006. Coming up on two years I've been on the Combined Antibiotic Protocol (CAPi) for Chlamydia pneumoniae (Cpni). A recent forum poster asked if anyone with CFSi has improved on the CAP. My response:

Damned right I'm getting better!When I started the CAP I was in a 2 year slide after 25 years of CFS, then added FMSi. For many years I'd struggled and somehow maintained a semblance of a life. Then over 2 years my pain, brain fog, restricted functioning, etc. slid to a point where I had to stop traveling and could for the first time see the possibility that I would become bedridden eventually.


I am so glad I found this site. I have been to so many Dr's and had so many wrong diagnoses.  Ashtma, Broncitis, enphasema sinisitis, cronic fatigue., FIbro Myalgia. Recently I found a new Dr. that thinks out of the box. Since I have been a heavy equipement mechanic for 35 years, he tested me for heavy metals, ant it came back positive for lead. My new Dr. also looked at my B12 and D3 levels which were both extreamly low. Now today I got the test results back from my CPNi IGG test, and it was positive. I have been getting B12 injections weekly now for 6 weeks along with suppliments of B12, D3, and an entire wiches brew of additional suppliments and probiotics. The 2 weeks of Axithromax felt like sticking a knife in my lungs along with feeling so bad I wanted quit the CAPi.


Hello, I was wondering if there is anyone out there that has been tested positive with the IGG antigen for CPNi?  I was tested positive a few weeks ago, but my own GP is not forthcoming with information on what this actually means.  I have had tinnitus">i for over a year, I always have a runny nose, I have mucus running down my throat most of the time, my glands on the right side were swollen a year ago, I have Asthmai, but i seem to out growing that, I have a nail infection that is not fungal, & a rash on my foot.  I am not sure if having the antibody actually means having some of the infection.  I know the tests are not conclusive and certain protocolsi need to be followed in order for accuracy, but I have only got so far with my own GP, and I am not getting the answers I need.

Cpn test evaluation help

Dear friends,


I am too glad to have found you and hope you can help me understand the evaluation of my test first.


I have been tested lately on chlamydia through the antigen method and found out the result is:

Cpni: IgG positive.... (index 2,76),  Limits should be 0.9-1,00, the lab also wrote a comment on the results saying: Anamn. titr. seropositive no signs of infection activity.



I am a bit speechless. How come everything is normal if my result of positivity is almost triple then the normal limit should be...?!


What do you think? 


Thank you very much for your time



CAP & Adjunct Treatment update March 11, 2009

Treatment Overview on March 11, 2009;

Diagnostic Evaluation May 24, 2007. Chronic Fatigue Sydrome - Progressive onset - 20 to 30 years to overwhelming fatigue, Fibromyalgiai, Mild Form.  C.Pn. positive by Lab test result > 1:512,  Bb positive by Lab test Western Blot after doxycycline taken for 3 -4 weeks for CPni, Borrelia Burgdorferi (Lyme Disease) was revealed as positve on Western Blot late July 2007.

Started CAProtocol 6-21-07 with Doxycycline, N-A-C and all supplementsi<,  CAP Progressed on 10-31-07 Macrolide-added, progressed 11-22-07 Tinidazole-added and also Cholestyramine HS PRN x 7d starting day 3 - 4 of pulse and continuing for +/- 7 days.


Hallo everybody,


I'm looking for labs who are doing tests on Cpnii and Mycoplasma and Doctors treating Cpnii in Toronto, Canada.

Can anybody help? 

18 Months on CAP

Dec 24, 2008 marks the completion of my 18th month of treatment.  I am antibody positive for CPni and Bb.  I started treatment on bacteriocidal level of Doxycycline 400 mg/day for almost 4 months before cutting back to 100 mg BID and adding Roxithromycin 150mg BIDi daily.  Those first 4 months were incapacitating and perhaps advantagious it is water under the bridge and I would not recommend it to others. 

Antibiotics to be available without prescription

This is the news:  In England, possible antibioticsi to be sold over the counter, to treat CHLAMYDIA!

This is the story form<

Oral antibiotics are to be made available for the first time without doctor's prescription under guidelines approved yesterday by the medicines regulator.

A pill to treat chlamydia, the most commonly diagnosed sexually transmitted infection, will become available for purchase in pharmacies across England later this year.

Case Reports from the Mitchell, Stratton et al patent

patent 6,838,552
                             TABLE 11
Serological and PCRi<i< Responses to Combination Antibiotic Therapy
Months of
Pa- Titer Antibiotic

Five Ways of Feeling Lousy

 Dr. David Wheldoni's succinct summary of the different reactions to Cpni and its treatment helps in sorting out the different responses and what to do about them. I've moved this from his comment in another members blog post to a page of it's own here in the Cpn Treatment Handbook.

Jim K (Editor in Chief) 

Five Ways of Feeling Lousy

I am inclined to think that there are five major mechanisms behind those unpleasant side effects of chronic large-load infection with C pneumoniae which worsen in the short-term with antichlamydial treatment.

a) Lipid peroxidation may likely get worse in the short-term as bacterial products are released both by breaking down EBs and by apoptosisi< of infected cells. Antioxidantsi<i< and B vitaminsi< (including B12) may help with this. I find melatonin">i<i< at night helpful.

And one more serology paper

 According to<

Clin Diagn Lab Immunol. 2003 January

Measurement of Chlamydia pneumoniae-Specific Immunoglobulin A (IgA) Antibodies by the Microimmunofluorescence (MIF) Method: Comparison of Seven Fluorescein-Labeled Anti-Human IgA Conjugates in an In-House MIF Test Using One Commercial MIF and One Enzyme Immunoassay Kit


"...The diagnosis of acute Chlamydia pneumoniae infection is usually based on the demonstration of at least a fourfold increase in immunoglobulin G (IgG) antibody levels in serum samples between the acute phase and the convalescent phase or the presence of IgM antibodies in any serum sample..."

PCR Analysis

Here< is a link to a detailed and technical paper on PCR analysis that evaluates and outlines the problem with culturing CPn and the variations in abilities in different labs. It also talks about the results of split samples and concordance between some PCR approaches and discordance with others. Though this is highly technical, it answers the question of how can it be that there are still some researchers producing papers saying, for example, that they tested patients with MSi for CPn and found the incidence to be no higher than controls, such as this article here< but note that this one used antibody tests, a ridiculously ineffective way of looking for CPn in cryptic form in the brain.

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