Cpnhelp.org

Cpn endotoxin is about 100 times less powerful than Neisserial endotoxin, but there must be a lot of it released, particularly with the active killing by metronidazole. Hence the need for caution at this stage of treatment. The long-term damaging effect of far more potent endotoxins on the CNS is vividly illustrated by this story: http://www.endotoxin.gmxhome.de/ which resulted in a letter in the BMJ: http://oem.bmjjournals.com/cgi/content/full/60/5/378

One quite common side effect of Cpn treatment is vestibular disturbance. A number of other medics who treat CFS with antibiotics have noticed this. It can go on for months, tends to have a diurnal rhythm and can be quite incapacitating. Its severity seems to be linked to bacterial load. The diurnal pattern suggests that it may be of host origin, perhaps cytokine. Here's a link to a webpage which notes the association between vestibular disturbance and cognitive deficits. http://www.backgroundfacts.com/menieres/COGDIS.htm

Useful information on use of Vitamin C to bind bacterial endotoxins.
Endotoxin and Vitamin C: Part I - Sepsis, Endotoxin and Vitamin C

Archie Kalokerinos, MBBS, FACNEM

Ian Dettman, PhD, BSc (Hons), ND, MACNEM

Cliff Meakin, ND, BHSc, AACNEM

Acute inflammation and infection maintain circulating phospholipid levels and enhance lipopolysaccharide binding to plasma lipoproteins
Richard L. Kitchens1,*, Patricia A. Thompson*, Robert S. Munford*, and Grant E. O'Keefe,**
* Departments of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9113
Microbiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9113
Surgery, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9113
** Department of Surgery, University of Washington, Harborview Medical Center, Seattle, WA 98104-2499

To whom correspondence should be addressed. e-mail: richard.kitchens@utsouthwestern.edu