We have been preparing this for an eventual overhaul of the Handbook, but there have been a number of requests, especially by new folks, to help clear up confusion.
Combination Antibiotic Protocols-
These charts are presented to give the brain-fogged an overview of protocols to understand the general approach, and why you may read of people on www.cpnhelp.org as using differing combinations of meds. These charts are meant for clarification only and should not be used as a starting point for doing a CAP protocol. Everyone’s case is different, and requires individual considerations. Also, understanding the many facets of Cpn and treatment reactions is crucial before engaging in treatment. Don’t start any of these without reading further in the Cpn Handbook.
Jim, I'm sorry not to have read this sooner, but you appear to be making a mistake about David's regime. You don't mention NACi until way down the list and the first alternative is given appears to be azithromycini by itself, which is incorrect as can be seen here:
A schedule of treatment.
This is one schedule which strikes all stages of the organism's life-cycle. Other equally good schedules are possible. It is preferable that a committed care-giver (for instance, spouse, partner or parent) should ensure that medication is given, and swallowed, consistently.)
N-acetyl cysteine (NAC) 600mg - 1,200mg twice a day, should be taken continuously. This is a commonly-taken dietary supplement, available at health-food stores. It is an acetylated sulphur-containing amino-acid, and may be expected to cause chlamydial EBs to open prematurely, exposing them to starvation; more on this and other benefits on page 4. This should be started at the lower dose of 600mg twice a day; the dose should be doubled when well-tolerated. NAC offers liver protection; this may be useful, as rapid bacterial die-off may compromise hepatic function.
When NAC is well tolerated, Doxycyclinei 100mg once daily is added. It is taken with plenty of water.
When the two above are well tolerated, Azithromycin 250mg orally, three times a week should be added. (Roxithromycini, 150mg twice daily, is an alternative.)
When all three agents are well tolerated, the dose of Doxycycline is increased to 200mg daily.
The reason for this slow, step-wise introduction of antichlamydials is to minimize any reactions caused by bacterial die-off. These can be unpleasant. NOTE: in rapidly progressive MSi it may be prudent to offset the benefits of stopping progression against the risk of reactions, giving full doses of azithromycin and doxicycline from the beginning.
This combination is taken continuously.
Also, The implication might be taken by some people that metronidazolei and tinidazolei are taken during a five day break fro the bacteristatics an this also applies to the Stratton Protocol. This would seem to answer my query as to why so many newbies were asking me this question..........Sarah