MediTest
27 Apr 2018
Author
Red
Title

Study: Vitamin D and T Cell Activation

Body

Here's a recent easy to read article discussing Vitamin D's importance for T Cell activation.   First a news article:

 And then the actual article abstract:

 Other studies have suggested that Vitamin D is important for T Cell activation as well:

Comments

Thank you ,Red, for this interesting study. sphinx

 Wheldon CAP May 2008,   52  Tini pulses - stopped Nov.2013- Buhner´s protocol Dec. 2013 till  June 2014 - cpn free Oct. 2014

 Good links and studies, but one can not go from these to thinking that taking D3 or D2 will work in increasing 1,25-D, the most active metabolite that has the highest affinity for the receptor. 1,25-D activates the VDR, however at normal physiologic levels 25-D does not do so or only very weakly. Taking high doses of D3 or D2 can actually lower levels of the more effective 1,25-D and act as an immuno-suppressant in my clinical experience. I have frequently seen people's 1,25-D levels drop when they take D3, especailly at higher doses. The logic of taking vitamin D3 to try and increase VDR activation is mistaken in most people, and in fact in chronic intracellular infections 25-D is often downregulated becasue of an excess in levels of 1,25-D caused by the disease process. We feel that activation of the VDR is essential of recovery of innate immune system response, and that taking D3 or D2 is apt to be immuno-suppressive in chronic chlamydial inflections.Randal

Thanks Red for continuing to add to the research base for Vitamin D supplementation.   Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Thanks Norman I was wondering who the we were as well and my thoughts did turn in a similar direction as well.  We will see when the representative of we returns.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support
Red

Tongue out

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

According to Dr. Yasko, rosemary helps increase vitamin D receptors (coumaric acid). Good to take a few caps along with your D each day---especially those of us who have a genetic defect in a VDR. I am happy to report my last D3 test was at 88 ng/ml. My doctor was pleased and my Cpn test levels have dropped significantly along with HHV6.Thanks for posting this, Red.Raven

Feeling 98% well-going for 100. Very low test for Cpn. CAP since 8-05 for Cpn/Mycoplasma P.,Lyme, Bartonella, Mold exposure,NAC,BHRT, MethyB12 FIR Sauna. 1-18-11 begin new treatment plan with naturopath

Thank you for posting this, Red. I too came across this article and wanted to post it here, but for unknown reason my button post comment sometimes doesnt work. Thanx also for articles about cancer and many others and for your neverending motivation to put these pieces together.
Btw: I too am on high dose vitamin D therapy along with cap with good results.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFS and many problems 30 years

Great feedback Lala that high dose Vitamin D is augmenting your progress with CAP.  Louise

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Thanks red for this research. I have in the last 4 weeks significantly titrated up my doses of vit D under my neuro's supervisioon and instruction- now on 7,000iu a day. I go for my next blood test this week. I have to say that I have felt not yet felt the benefits of vit d being intoroduced ( in fact in the early weeks it was quite the opposite- perhaps the antibicrobial actions at work) but I look forward to the longer term benefits- having been a fall out from the member of the other unmentionable protocol that after 3 years, no longer worked for me! ( couldn't resist puting that in as 3 years was a long time to follow a protocol that eventualy did not deliver and may even have done damage?, who knows. But my neurologist is no longer prepared to see me with my type of symptoms- if I do not get my vitamin D levels up.) 

FMS/ME dx 2001. Started Wheldon Protocol 16 Jan. '10. Mino 100mg q 24 h. Roxy 150mg q 12h. Cholestyramine, LDN 0.75mg q 24 h. prophylactic migraine-topamax 75mg q 24h. migraines, headache, fatigue, sleep problems, body aches

   Red, thank you for this good job.   Randal, ıf we assume that what you say is true, we should expect immune suppressed people with lots of infections on their body in equatorial places or sunny places and we should expect also a flare up of infections in summers, do you have any data indicating this? yılmaz

KEREM'S TAKECARER;Suspıcıon of MS (transient nystagmus during conjugated gaze on february 2008, blepharospazms and some optic complaints on february 2009-no plaque on MRI), Vit D3 started 400 IU and elevated to 2000 ıu ın 40 days.

  My levels have changed as follows and I live in the U.S. sunbelt with high UV rates which I get at least 30 minutes per day.  Starting with CAP and a D3 supplement one year ago the levels were 20 ng/mL of D3 and my NK percent was at 4%.  At the one year mark my vitamin D3 level is at 56 ng/mL and my NK percent is at 13%, about midrange according to Quest Lab for the NK cells percent.  I started with 6000 IU/day of D3 and increased at every three month blood test interval.  I am now at 12,000 IU/day and will try to maintain the D3 level in the 70-80 ng/mL range.

Cpn, Mycoplasma, Chronic EBV, M.S.(MRI, Spinal Tap-greater than 5 oligoclonal bands and VEP), PANDAS(OCD). Wheldon CAP (started 12/08), Azithromycin/Clarithromycin(12/09), Lithium, Lamictal, NAC(2.4g/day), D3(15,000IU/day)

Red