27 Apr 2018

Short Vid on Chalmydia survival strategies


Came across this short but very interesting video on how chlamydia survives in the cell. This is one tricky organism: http://uk.youtube.com/watch?v=kpUzSbM4klg 


Really excellent. The apparatus is the same for Ct and Cpn, so it really gives some clarity on how Chlamydias defeat cellular defenses.

Thanks guys. Where else can you learn about Chlamydia's needle-like type-3 secretion system, its hijacking of the cell's golgi apparatus to cloak itself and have an impersonation of a hispanic Ned Flanders thrown in for good measure? All in just over 2 minutes. That's what I call bang for buck.

Here are some choice quotes:

"Usually within a cell, lysosome fuses with an entry vacuole harbouring foreign intruders. But because of a needle-like projection called a type-3 secretion apparatus the bacteria may inject some of their own proteins into the outer membrane of the entry vacuole. These proteins physically block the lysosomes assualt."

"Chlamydia can also hide from lysosomes by refurbishing their entry vacuole with molecules they divert from the host cell's lipid distribution centre, otherwise known as the golgi apparatus. These stolen lipids make the vacuole virtually indistinguishable from the cell's own organelles."

"Buenos ding-dong-diddly-dias senior!"

"And this is why chlamydia is so hard to stop."

Hunter: Don't think - experiment

Required viewing for everyone I think.   Is there some way in which we can preserve this for future use...    Its fun, short and informative.  

As for the training of new doctors, they will need to read the comments below also or they will think this refers only the Ct.

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.

Why do I have a sense of familiarity with these guys?  This really brings home my saying that PPMS in its aggressive time is an exponential rampage.  Thanks, Garcia.

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Michele- I've got this saved just in case it gets dumped from Youtube. You might put a reference link to this in the Getting Started, or maybe it's better in the Handbook?

I particularly like the Homer Simpson "Oo, forbidden donuts" and "Doh!" for the lysosome sounds!