Seropositivity for Cpn in biliary cirrhosis.

Submitted by Jim K on Sat, 2006-03-04 20:42
Gastroenterol Hepatol. 2006 Mar;29(3):113-7.
Click here to read 
Seropositivity for Chlamydia pneumoniae in patients with primary biliary cirrhosis.

[Article in Spanish]

Montano-Loza A, Vazquez-Ballesteros E, Meza-Junco J, Villalobos-Zapata I, Olivera-Martinez M.

Departamento de Gastroenterologia. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran. Mexico DF. Mexico.

INTRODUCTION: Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by inflammatory injury and bile duct destruction. Recent studies suggest that Chlamydia pneumoniae could be associated with the development of PBC. The aim of this study was to determine the seroprevalence of C. pneumoniae in a cohort of patients with PBC. Patients and Methods: The presence of IgG antibodies against C. pneumoniae was investigated in 46 patients with PBC and in 105 subjects without cirrhosis. RESULTS: Twenty-one patients (46%) with PBC had antibodies against C. pneumoniae compared with 74 subjects (71%) in the control group (OR = 0.6; 95% CI, 0.3-1.2; p = NS). Subanalysis of the PBC group showed that patients with C. pneumoniae antibodies had a higher frequency of advanced Child-Pugh stages (24% A, 52% B and 24% C vs 64% A, 32% B and 4% C; p = 0.01), a higher score on the Mayo Clinic Prognostic Index (7.8 +/- 2.1 vs 5.6 +/- 1.2; p = 0.004), a higher frequency of ascites (29% vs 4%; OR = 9.6; 95% CI, 1-87; p = 0.02), higher total bilirubin levels (4.5 +/- 2.5 mg/dl vs 2.4 +/- 4.3 mg/dl, p = 0.001) and lower serum albumin levels (2.6 +/- 0.9 g/dl vs 3.3 +/- 0.6 g/dl, p = 0.02). CONCLUSION: No association was found between C. pneumoniae infection and PBC in this study. An association was found between the severity of PBC and C. pneumoniae, which may suggest a deleterious effect of C. pneumoniae infection or a predisposition in advanced stages of PBC to acquire infection with this microorganism.

PMID: 16507276 [PubMed - in process]

I'm wondering if anyone can lend a hand /suggestion for a friend of mine who has what is called a   " fatty liver".  I am not  extremely familiar with what a fatty liver means or  what primary biliary cirrohosis is so I apologize in advance.  My friend also has an ulcer, high blood pressure and high cholestral. Other than that he's rather healthy.  As I read what other diseases are related to Cpn I can't help but want to have him print the Handbook and take it to his Dr. yet am unsure if this is for him.  I think the NAC would be something that could help protect his liver, yet the protocol might not be?  As you can see, I'm so new with all the info do you blame me for reaching out to some of you with so much more knowledge?  Gosh, it's so difficult not to tell people in your life about Cpn and perhaps the benefits of the protocols.  If I am off base on this thought I'd like feedback so I don't get him interested if in fact it's not for him. Any help or suggestions would be appreciated.


From googling, fatty liver disease, assuming there is no alcoholism, it can range from simple fatty deposits to inflammation of the liver (of unknown origin) to scarring and cirhosis. It is usually attributed to obesity and "lifestye" or diabetes. The study below, along with the high BP and high cholesterol (both common observations at Cpnhelp from members prior to CAP) certainly is suggestive of possible Cpn. Looking at the BP results from Ron's survey, and Rica's husband who has also found BP lowering effects of the CAP-- without any other suggestive Cpn diseases concurrent-- I'd personally be trying this protocol on the BP results alone.

I suspect this all may be more of a stretch for his doctor even then for more arguable Cpn related diseases. So, how convincing is your friend? 

Dig Dis Sci. 2005 Jun;50(6):1141-5.

High rate of seropositivity of Chlamydia pneumoniae IgA in male patients with nonalcoholic steatohepatitis.

Bolukbas FF, Bolukbas C, Zeyrek F, Aslan M, Bahcecioglu HI, Ozardali I.

Department of Internal Medicine, Gastroenterology Division, Harran University, Medical Faculty, Sanliurfa, Turkey.

The aim of this study was to investigate if there was any relationship between nonalcoholic steatohepatitis and the rate of Chlamydia pneumoniae seropositivity in a male population. Fifteen men with nonalcoholic steatohepatitis and 20 healthy men were enrolled in the study. The seropositivity rate of Chlamydia pneumoniae immunoglobulin A in the nonalcoholic steatohepatitis and control groups was 53.3 and 5%, respectively. The rate of Chlamydia pneumoniae immunoglobulin A positivity was significantly higher in the nonalcoholic steatohepatitis group than the controls (P = 0.002), while such a difference did not occur for Chlamydia pneumoniae immunoglobulin G positivity (P > 0.05). There is an association between nonalcoholic steatohepatitis and persistent Chlamydia pneumoniae infection as a probable causative or triggering agent. These findings suggest that further studies are necessary to clarify this association.

PMID: 15986871 [PubMed - indexed for MEDLINE]


Combined Antibiotic Protocol for Chlamydia pneumonia in Chronic Fatigue Syndrome & Fibromyalgia- Currently: 150mg INH, Doxycycline/Zithromycin, Tinidazole pulses. Northern Ohio, USA


CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Sojournersister, Probably the first step in getting treatment for ones condition is to understand it.   So over and above what Jim has said, it may be an idea for your friend to read the book writtent by Russ Farrel called the Potbelly Syndrome.   It addresses a number of different conditions and explains really clearly how Cpn operates in the body and what results may transpire due to its parasitic existence in our bodies.

Michele:  on Wheldon protocol since 1st May 2006 for a variety of long standing ailments, also spokesperson for Ella started Wheldon protocol 17th March 2006 for RRMS

Sussex, UK

Michèle (UK) GFA: Wheldon CAP 1st May 2006. Daily Doxy, Azi MWF, metro pulse.