nord 13 Dec 2010 09:10 am Interesting, I didn't know Interesting, I didn't know that detail of the Gasser protocol. Both drugs have a half-life in the same range (10h), and peak plasma conc. at 1-2 for Roxi vs 2-4 for Bactrim. Roxi almost entirely binds to proteins, while the substances in Bactrim only partially does. Perhaps the explanation lies here, or in absorption (roxi to be taken well before meals, while Bactrim is easily absobed)? Only wild speculations. Are there other things to consider if adding Bactrim to a Wheldon CAP (with Plaq/Hydroxychloroquine in my case)? Now at day five of tini pulse my soles start burning a little (has been a lot better off tini); thinking tini perhaps causing a Babesia reactivation or "herx". There is also the question of dosage; Gasser used a 300mg bid scheme for rox, and a similarly high (twice standard) dosage for Bactrim, if I recall correctly. Quite an increase/addition to a CAP. Borrelia/Cpn arthritis: joint, skin, eye, CNS, respiratory, UG involvment; fatigue. Borrelia: Clinical, Elisa&WB IgG, and CPn IgG and IgA pos, HLA-B27 neg. (2010). CAP 5/9/2010 -> 3/2016 2017: some signs and symptoms returning, Borrelia?