Submitted by mrhodes40 on Mon, 2007-08-06 11:10

Med Hypotheses. 2007;68(2):278-80. Epub 2006 Oct 11.
Role of Tryptophan supplementation in the treatment of Chlamydia.Singla M.
Department of Pediatrics, University of Illinois, 840 S. Wood St., CSB Chicago, IL 60612, USA. msingla@uic.edu

Chlamydia trachomatis, an intracellular pathogen, is the leading cause of preventable blindness and sexually transmitted infections in the world. Infection of epithelial cells with Chlamydia results in the production of antigen-specific IFN-gamma -secreting CD4+ and CD8+ T cells. IFN-gamma activates indoleamine 2,3-dioxygenase (IDO), an enzyme that degrades tryptophan in the host cell. This IDO mediated tryptophan starvation is known to activate genes for persistence in the Chlamydia, which renders antibiotics ineffectiveness against it. Tryptophan supplementation causes reactivation of Chlamydia from persistent into metabolically active forms and then the antibiotics easily eradicate these active forms of Chlamydia. Therefore treating the chronic Chlamydia infection with antibiotics and tryptophan together may lead to better clearance of Chlamydia infection, and may be a better therapeutic approach in the future.

PMID: 17045416 [PubMed - indexed for MEDLINE

Comments

Marie,  May I assume that you are working on a comment about the fallacy of this strategy for the benefit of newbies?Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAP since August 06, antivirals, heavy metals chelation, LDN, Metanx, Lunesta, GF/CF diet, Lauricidin, oral IgG/lactoferrin/IGF-1 booster, astaxanthin, gamma oryzanol.

Joyce~caregiver-advocate in Dallas for Steve J (SPMS).  CAP since August 06, Cpn, Mpn, B. burgdorferi, systemic candidiasis, EBV, CMV & other herpes family viral infections, elevated heavy metals, gluten+casein sensitivity. 

 The problem with this hypothesis is that tryptophan starvation is not the only stimulus that induces persistance (transformation to cryptic state): antibiotics will do this also. This means that you are still inducing persistant forms by the antibiotic treatment while feeding the replication phase with tryptophan. Remember, the authors of this hypothesis are basing their attempt to defeat the well known persistence factor in Chlamydia still within the mono-antibiotic model. The microbiological world, as well as the medical world, remains ignorant of the Vanderbilt findings about Flagyl killing the cryptic form, as this was never published in a scientific journal. Now, maybe there's a possible strategy here (inducing more EB to convert to RB by tryptophan supplementation while inhibiting replication, and knocking out the cryptic persistent forms with Flagyl pulses) but I'd like to hear a micribiologist comment on this before I'd experiment with it myself. CAP for Chlamydia pneumonia since 11/04. 25yrs CFS & FMS- Currently: 300mg INH, 200 Doxycycline, 500mg MWF Azithromycin, 1000mg Tini daily (Taking a break from continuous protocol)

AH Jim you beat me to it. I was going to say this is a hypothesis and maybe it is pertinent; maybe not. It is here as part of or data base because it is interesting not because we want everyone to start to do this....It was published in Medical Hypotheses after all!

Here's another thread on tryptophan

marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5. Currently on: Doxy 200, Azith 3x week, Tini cont. since April '07, all supplements.
"Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

I tried tryptophan along with antibiotics about 2 years ago. It was an interesting time, and i did not continue long with tryptophan. I cannot say I felt more dieoff or anything but the hormone effect was quite intense, and put me out of sync. I suspected that the cpn had depleated my reserves of tryptophan and was a possible cause of poor sleep. The effect was like walking around half asleepin a dream, and with a very wierd head.    Diagnoised 98 with ReA (reactive arthritis), Cpn found in eyes! after2 years of study and some trials with Cipro and Biaxin ReA passed. since then colon complications. Did lamisil and fungizone for one year recently, big improvement. Yet still colon probl

Diagnoised 98 with ReA (reactive arthritis), Cpn found in eyes! after2 years of study and some trials with Cipro and Biaxin ReA passed. since then colon complications. Did lamisil and fungizone for one year recently, big improvement. Yet still colon pr