post pulse 12

Submitted by farandwide on Thu, 2007-05-17 12:31

I just finished pulse 12 yesterday.  It went as all of the previous pulses went, with one small exception.  I'm not even sure if it was the pulse or something else.  Allow me to elaborate.

As I've mentioned in the past here, I go to the gym on a regular basis.  I generally take my final dose of abx immediately after I finish working out.  At times when I'm pulsing, this would include the final dose of flagyl.

So on Tuesday of this week, about 15 minutes after taking my final abx of the day, I was standing and talking to a friend at the gym, preparing to leave.  I suddenly got VERY light headed, so much so I had to sit down.  My balance went all haywire and I almost lost it going from where I was standing to a chair nearby.

I reclined in the chair for about ten minutes, hoping that the loss of balance was some weird temporary result of over exerting myself or maybe just lack of sleep.  I do tend to get less sleep than I should during the work week.  At the end of ten minutes, I stood up and walked to my car.  My balance was still out of whack, but I was prepared for it and very carefully, stumbled and listed my way to my car, got in, and drove home.

By the time I got home, I got out and walked inside.  My balance had come back in the 10 or so minutes that I took to drive home. 

Consequently, I have no idea what it was that caused this, but it's a first time thing.  Well, first time since eight years ago when I had vertigo.  But even then, my balance never did this.  I could close an eye and be fine back when the vertigo happened.  Closing my eyes would have made me even worse this time.

In any case, it went away by the following morning and hasn't returned.  There are a lot of theories about it I could pose but the bottom line is I have no idea which one is the most likely and probably never will.  It's one of those mysteries that happens while one is in recovery from something like Cpn.

On another note, I have to say I thoroughly hate doxycycline.  About eight weeks ago, I started taking the full daily dose all at once rather than half the full daily dose twice per day.  It's nauseating, yuck.  Azithromycin doesn't have this effect, nor does metronidazole, but I definitely hate doxy lol!  Yucky stuff.  Picture a very sour face, I'm making one as I think about it, lol!!!

John

Well, who's the lucky one who gets his metronidazole as capsules!Image removed.  Doxycycline does taste a bit funny if you don't straight away drink a glass of water with it, but I find it alright otherwise.  I do have to eat something with it though, or I feel sick, even have been once or twice before I learnt better.    As for the light-headed feeling, I never used to get it, but now I sometimes do, although, like you, it doesn't last long.  I presume with me it is something to do with the last ditching of endotoxins.........Sarah  An Itinerary in Light and ShadowWheldon regime since August 2003, for very aggressive SPMS.  Intermittent therapy after one year. 2007 still take this, now two weeks every three months, but still slowly improving and no exacerbation since starting. EDSS was about 7, now 2.
Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Ugg....I take the full dose of doxy with plenty of water and no food.  It still turns my stomach.  Just thinking of it turns my stomach.  I'm being a bit whiny about it because I don't plan on doing something like eating a cracker with it to lessen the effect.  I figure that it's the pennance or price  I have to pay to get through this.

Taking doxy in 2 100mg doses a day is easier from the nausea standpoint but taking it in 1 200mg dose is easier from the scheduling standpoint.  The CAP is more manageable that way.

I'm glad I never had to take metronidazole as a pill.  I count my blessings, which is easy, I can only count so high ;-)

all my best

John

RRMS/EDSS was 4.5, now 4.??? on Wheldon Protocol (nac, doxycycline, azithromycin, metronidazole) since 04/12/2006

best, John

RRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
nac 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day

Doxy made easy:
  • Take Doxycycline capsules with a full glass of water.
  • It is best to take your capsules at the same time(s) each day, when standing or while sitting.
  • It is important not to lie down for at least thirty minutes after taking Doxycycline capsules, so that the capsule can move as swiftly as possible into the stomach and prevent irritation of the throat or oesophagus (canal taking food from the mouth to the stomach).
  • Doxycycline may be taken with milk or a meal.
I take 200mg with lunch and a large drink.  No problems at all.   Mark 

Mark Walker - Oxford, England.

RRMS Nov 91, Dx 97. CFS Jan03. DW Patient Jan06. CAP (NAC, Dox, Rox) with Copaxone Feb06. Met monthly pulses, from Jun06. Pharma Consultant (worked til Jan03)

Mark Walker - Oxford, England.

RRMS Nov 91, Dx 97. CFS Jan03. Copaxone + continuous CAP (NAC, Dox, Rox) Feb06 to May 07. Met pulses from Jun06. Intermittent Abx from June 07 onwards.

 Taking it with food has been the key for me also. Empty stomach? No way!

CAP for Chlamydia pneumonia since 11/04. 25yrs CFS & FMS- Currently: 150mg INH, 200 Doxycycline, 500mg MWF Azithromycin, 500mg Tini daily (Continuous protocol)

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

John, after 32 months I STILL get vertigo, though nothing to compare with the past. And it usually comes our of nowhere like yours. And as for your suffering with the Doxy, please do eat something. Did I miss something or have you changed your signature again? I could look it up but am too tired (lazy!)! Also like you, we don't get enough sleep during the week.

 

Rica PPMS  EDSS 6.7 at beginning - now 2.  Began CAP Sept, 2004 with Rifampin 150 mg 2xd, Doxy 100 mg 2xd, added regular pulses Jan 2005. Jan 2006 switched to Doxy, Azith,  cont. flagyl  total 42 pulses NC USA

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Hi Rica          

Well,  what I had on Tuesday wasn't vertigo, it was different.  When I had vertigo in the past, the room was spinning.  I couldn't focus on a single point and hold my vision on that point, it was all moving.

This time, it was a sudden, severe loss of balance.  I was standing and I got light headed.  When I went to walk, I almost fell down.  It was like the floor was suddenly tilting as if it was balanced on a single point below me.  Any movement in any direction would cause the floor to suddenly tilt down in that direction.

In any case, it passed and I seem relatively back to baseline.

Yes, you've caught me.  I did indeed change my signature after pulse 11.  However, since I don't post that often, it probably isn't an easy thing to notice.  Thanks Image removed.

all my best

John

RRMS/EDSS was 4.5, now 4.??? on Wheldon Protocol (nac, doxycycline, azithromycin, metronidazole) since 04/12/2006

best, John

RRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
nac 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day

I didn't know you had to take doxy on an empty stomach for better effect. I could never do that. It'd just give me a bout of projectile vomiting, I'm sure. But I do take Roxy on an empty stomach, about 15 mins before food. Then on finishing my meal, I take the doxy. Mine are little green pills as opposed to capsules. I hope that doesn't make any difference! Began CAP Oct.06 for SPMS. Currently on Doxy/Roxy. No pulses as yet.
Began CAP Oct.06 for SPMS. Currently on Doxy/Roxy. No pulses as yet.

You don't have to take doxy on an empty stomach for better effect.  Dramatic effect maybe!  I take doxy and roxy both together about five seconds before breakfast, including a glass of milk.   John, I didn't notice your signature: you sneaked that in quietly.  Well done!.........Sarah   An Itinerary in Light and ShadowWheldon regime since August 2003, for very aggressive SPMS.  Intermittent therapy after one year. 2007 still take this, now two weeks every three months, but still slowly improving and no exacerbation since starting. EDSS was about 7, now 2.
Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Sarah        

lol!  I'm sneaky that way I guess.  It's just a minor change, very kind of you and Rica to notice.

Something you said to Annette confuses me.  I've always heard (and read) that one should wait 30 - 60 minutes after taking doxy before a meal but you're saying 5 seconds is enough?  What if one's breakfast consists of food high in calcium?  Do we know ahead of time if it does?  Wouldn't it be safer to buffer between the two, if one can do so?

all my best

John

RRMS/EDSS was 4.5, now 4.??? on Wheldon Protocol (nac, doxycycline, azithromycin, metronidazole) since 04/12/2006

best, John

RRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
nac 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day

 The concern about calcium actually derives from the early understanding of tetracycline which is easily blocked by calcium. Doxy is not so sensitive to this. So it's probably not a good idea to take it with calcium supplements, but quite fine to take it with food that might contain some amounts of calcium. Mark has provided an information sheet we have in the appendix of the Handbook.

CAP for Chlamydia pneumonia since 11/04. 25yrs CFS & FMS- Currently: 150mg INH, 200 Doxycycline, 500mg MWF Azithromycin, 500mg Tini daily (Continuous protocol)

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

John, if you don't want to see me being sick, five seconds is enough.  Over indulgence in calcium at the meal would not be a good idea, because it might interfere with the absorption of doxycycline, but a small glass of milk is fine.  A meal very rich in cheese would not be a good idea, but I'm not German, so I don't eat cheese for breakfast.  If you take yours nearer dinner time, a small amount of parmesan on your Spaghetti Bolognese won't hurt, just avoid the cream and calorie rich dessert, but I guess you do anyway.........Sarah   An Itinerary in Light and ShadowWheldon regime since August 2003, for very aggressive SPMS.  Intermittent therapy after one year. 2007 still take this, now two weeks every three months, but still slowly improving and no exacerbation since starting. EDSS was about 7, now 2.
Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Goodness, take it with food! I do not like to eat breakfast so I have on several occassions not eaten then forgot that I did not eat and took my doxy and vomited within a half hour. Every time I say to self "Dummy! Eat food then take doxy!" Doxy is irritating to the stomach food ameliorates that. The only reason to take a pill on an empty stomach is if it is going to bind to the food an become ineffective, doxy does not do this so we are good to go. One thing that is clear from the research on CPn is that it takes your energy at a cellular level. If you work out it seems wise to be sure you have eaten properly and that you rehydrate and refuel appropriately so your body overall has what it needs to function. I also work out at a gym and I take along a sports drink (which has some frunctose in it but that big deal over all my diet is not high in fructose and it is still energy) just to be sure I do not get low. If you ever watch the ironman race you can see sometimes people "bonking" or running out of energy completely an collapsing; in one famous race this occurred mere yards from the finish in a contender. If you do not replace what your body needs it will reach a line of "there is no more". It just seems to me that line of non function is probably lower in us just because of how the germ works in your body. marie On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5. Currently on: Doxy 200, Azith 3x week, Tini 2x month, all supplements. "Color out side the lines!"

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro