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Porphyria & CabbageSubmitted by Mark Hall on Sun, 2008-08-03 12:01. Is it definately the case that certain foods like cabbage can increase porphyrins? What has been everybody's experience with this?
If this is the case i cant understand how it would make a difference to secondary porphyriai Thanks Mark ___________________________________________________________ UK Carer of bedridden Severe ME/CFS Feb06. CPNii dx. Apr07. Borrelia dx Sept08. Samento 15 drops per day July07. 2400mg NAC 200mg. Doxyii Jan08. 300mg Roxyii Apr08. »
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Hi Mark,I notice greatly
Hi Mark,
I notice greatly increased secondary porphyriai symptoms with members of the cabbage (brassica) family. Studies suggest that they increase cytochrome p450 activity. Here's one study:
Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets.
More info:
http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1019936698
From the American Porphyria Foundation site:
"Many drugs that make porphyria worse do so by increasing the synthesis of hemei and its precursors in the liver. When the liver in a patient with acute porphyria is induced to make more heme, the genetic block in the pathway (the heme biosynthetic pathway) becomes exaggerated and heme precursors accumulate. Heme made in the liver is used mostly to make certain enzymes found in the cytochrome P450 (a metabolic pathway). Therefore, when a drug causes the liver to make more cytochrome P450 enzymes, it induces the liver to make more heme precursors, and then an exacerbation of a genetic porphyria can follow."
Here's a good list of members of the Brassica family:
http://en.wikipedia.org/wiki/Cruciferous_vegetables
Mustard used to always set me off, pre-CAPi, with terrible rosaceai flushing, headaches, etc. I assumed it was some sort of vasoactive amine in mustards that caused this. Now I'm wondering if this reaction was due to a large increase in porphyrins...
Hope this helps. Hang in there...
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On Combined Antibiotic Protocol for Cpni in Rosaceai 01/06 - 07/07, On Vit D3 + NACi since 07/07 and daily FIRi Sauna since 08/07
Apiaceous vegetables eg.
http://en.wikipedia.org/wiki/Apiaceae
Shame that broccoli is a brassica - I love them all, although I have to say that I have not noticed any bad effects from occasionally eating them. But fortunately I do love parsnips although they are best after the first frosts, rather than now.
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Progressive MSi dx2006. LDNi & CAPi: Wheldon version. All supps. Doxyi 200mg. Zithi 250mg. Metroi 400mg.Pulses #14...I can because I think I can.
Brocolli does it for me
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CPNi pcri and antibody positive , treating MSi,
CFSi, TMJ, trigeminal neuralgia,IBSineutropenia, pus found in facial bone,Doxyi 100x2,Doxy 200x2 zithro 250x1 alternate days. Metroi pulses each month.