I have Interstitial Cystitis and have been doing antibiotic therapy and the NP that I am have treating me wants me to take plaquenil to see if I have a die off reaction, I am currently taking ammoxicillin and augmentin and flucanzole for yeast. Plaquenil has drug interactions with cymbalta which I am also talking. i am nervous to take it....Two years ago I took minocycline and rifampin and had horrible die off reaction and then for months I barely had any bladder pain or issues. then it came back again. She is basing this on the Fry bug theory, she thinks I might have that.