What I can and cannot take NAC and ABX

I have come across a direction to not take NAC with ABX (see "Drug interactions" here):

"If you are taking antibiotics, NAC should not be taken, as it will weaken their beneficial effects."

I did a quick search of this site and read that ABX should not be taken with Calcium or Magnesium, and that ABX cancels out probiotics (my Doxycycline has 90B Lactic Acid Bacillus in each capsule), but nothing specific to taking NAC and ABX at the same.  

I have 2 questions, and would appreciate any info: 

  • What are the parametres when taking NAC?   
  • What are the parametres when taking ABX?

Corinna, your are correct, I think, that you must not take abx with cal/mag. As for the NAC, I take my AM supps with my coffee, including NAC, calcium, magnesium, and probiotics,. Then I take nothing for two hours, after which I take my abx for the day. I wait about 45 minutes and then eat something nutritious. I have done abx for almost four years and am still improving.

3/9 Symptoms returning. Began 5 abx protocol 5/9 Rifampin 600, Amox 1000, Doxy 200, MWF Azith 250, flagyl 1000 daily. Began Sept 04 PPMS EDSS 6.7 Now good days EDSS 1 Mind, like parachute, work only when open. Charlie Chan  In for the duration.&am

Rica, that seems a prudent scheduling, I will adopt it starting tomorrow. Thanks.

Am I reading this correctly then that you take all your ABX at one sitting? 

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Thank you for this post as I have not run across this (haven't thought to look for it) and I have been taking NAC and abx together.  Sorry I can't give more insight as I obviously was oblivious, but I will NOW take my NAC with my supplements .  I knew not to take abx with calcium and magnesium, which is why I took my NAC with my abx, in case calcium and magnesium affected NAC, also!  Now I wonder if calcium and magnesium could affect NAC or not?

Reve'

Memphis,TN - FMS, IBS, rhinitis, depres (~20 yrs) CFS, intestine, bladder, pelvic inflam., red itchy skin, anxiety (~5 yrs). CPn titer 1:256.  CAP 6-07 Current NAC 2400mg; doxy 100mg x2, Biaxin 500mg x2, supplements, 1st pulse Flagy

I also wonder if it is ok to take NAC with food?  I assumed it would be, but maybe I should look that one up also!  So much to juggle!

Memphis,TN - FMS, IBS, rhinitis, depres (~20 yrs) CFS, intestine, bladder, pelvic inflam., red itchy skin, anxiety (~5 yrs). CPn titer 1:256.  CAP 6-07 Current NAC 2400mg; doxy 100mg x2, Biaxin 500mg x2, supplements, 1st pulse Flagy

I just read that article more thoroughly.  That is a very good article.  I learned a lot and it sounds as if taking NAC with food may be ok.

 

Memphis,TN - FMS, IBS, rhinitis, depres (~20 yrs) CFS, intestine, bladder, pelvic inflam., red itchy skin, anxiety (~5 yrs). CPn titer 1:256.  CAP 6-07 Current NAC 2400mg; doxy 100mg x2, Biaxin 500mg x2, supplements, 1st pulse Flagy

Okay, let me lay your concerns to rest. The antibiotics you are likely to be taking are not affected by NAC. This is a topic/issue that concerned me enough to post about it a couple of years ago here...

http://www.cpnhelp.org/?q=nac_question

You will find in the thread the explanation of why it isn't an issue.  If you want to shoot right to a source document on it, here is the link within the thread to it.  Go to the section that talks about side effects.

http://www.thebody.com/content/art4754.html

best, John

RRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
nac 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day

John, many thanks for your post. The thread you linked to covers Doxycycline, but what of Roxithromycin, Azithromycin, Tinidazole, Rifampicin and Metronidazole, are they okay as well?

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Corinna, Many people do take both doses of doxy and roxi at the same time once a day I believe. Those of us sensitive sorts may do well to choose to devide the doses of both of these. After a year I have experimented with taking my doxy at my evening meal both doses. And after a year I am less aware of the blood level rise. Others will say that it makes no difference for them from the start. Wish I could say the same. However if my evening meal is a sparse one then I have the stomach sentitivity issue to deal with so for me I have been most consistent deviding the dose. I started my Doxy tx at 200 mg twice a day per instruction. I had massive die-off and porphoria, I was laid low and not able to do much of anything, I was one sick chick. Just a word of caution from my perspective, if you need to work start slowly and work up to trying to take all the Abx at one time daily just in case. We have time, lots of time, in fact time is what makes this approach effective as I have read. I am one year in on the 3 - 5 year plan. So far much improved. Louise
  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

I'm one of those horrible people who take all the abx in one go. Friday morning it was 2 x Doxy, 1 x Zith and 1 x Metro. I take half the daily NAC dose at the same time as well as a few other supps.

The rest I take at night before bed.

Berkshire, UK. Diagnosed RRMS Feb 4th 2008.

NAC 2400mg. All supps. Doxy 200mg. Zith 250mg. Metro 400mg.
No GP/Neuro support. Self medicating with help from David Wheldon.
Started CAP 20th April

Andesine, I'm with you. Cal/mag at night, most abx in the morning with NAC and most other supps, then whatever I couldn't chug down in the morning I take after work. ;-)

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

 

Corinna, Ken and Reve, you don't have to separate NAC from anything else.  Some people do but I never did, just separate calcium and magnesium and always make sure your stomach is empty before taking charcoal, if you do. 

And drink plenty of water!...........Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Thanks Sarah! Your word is golden on the subject. I appreciate your input. Since vitamin C powder is buffered with both magnesium and calcium I now know that there can be no Emergen-C, and the like, near the ABX time.

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Corinna,

Don't you mean no Emergen-C near abx time?  I think the consensus is that it is OK to take NAC with cal/mag. 

My question is do we have to worry about the magnesium and calcium that occurs naturally in our food interfering with Doxy if we take it with food.  I am sure it is possible to eat a meal that is high in those two minerals.

Tina 

 Tina-MS 37 years;EDSS 4.5   1/1/08 Wheldon CAP; Azith 250mg 3 x a week; Doxy 200mg daily, NAC 2000 mg daily, started Flagyl pulse 4/14/08.

 

 

Corinna, I did just mean separate calcium and magnesium tablets from antibiotics, charcoal from everything.  The amount of calcium and magnesium used as a buffer in anything is minimal compared to what you get in  calcium or magnesium tablet, so don't worry about it.  I used to drink a glass of milk to stop feeling nauseous with doxycycline, or would have a bowl full of cereals with sometimes full cream milk.  When I was splitting the antibiotics up, I wouldn't worry about what I was eating with them.

If you are taking emergen-c for a clear out, though, don't take it until two hours have passed from taking antibiotics or they will be wasted, likewise wait to take them until the emergen-c has worked!  Anything else will be wasted as well, but one day's loss of supplements matters not............Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Thank you Sarah. All of this information is very helpful.

My husband, Tim, has started the supplements now and we are creating a routine so that things are timed appropriately. It does get easier to get a handle on it all in short order, and having my partner participating makes it even easier.

Tim learned the wonders of Emergen-C two days ago. He was feeling quite out of sorts and coming down with a migraine. Typically his visual auras last an hour and then he has pain and a 'numb' head for the remainder of the day or more. This time, within 5 minutes of taking Emergen-C his vision was clear and within the hour he was almost back to normal. This is unprecedented. We were amazed.

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Another thing then: don't pulse together or murder might ensue!

Best of luck to both of you...........Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.