Unexpected antimicrobial effect of statins.

J Antimicrob Chemother. 2008 Feb;61(2):362-4. Epub 2007 Dec 17.Click here to read Links

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        J Antimicrob Chemother. 2008 Jun;61(6):1400.

    Unexpected antimicrobial effect of statins.
    Jerwood S, Cohen J.

    Department of Microbiology and Infectious Diseases, Royal Sussex County Hospital, Eastern Road, Brighton BN2 5BE, UK.

    OBJECTIVES: Epidemiological studies of statins have suggested a link between statin therapy and a decreased risk of sepsis. It has been proposed that the mechanism underlying this apparent protective effect of statins relates to their known immunomodulatory and anti-inflammatory effects. The aim of this study was to explore the antimicrobial effect of statins. METHODS: Simvastatin (Merck) and fluvastatin (Novartis) were both tested against six of each of methicillin-susceptible and -resistant Staphylococcus aureus (MSSA + MRSA), and vancomycin-sensitive and -resistant enterococci (VSE + VRE) using a microtitre dilution method. The test was repeated five times for both statins against all 24 isolates. Vancomycin, linezolid and propranolol were used as controls, as appropriate. RESULTS AND DISCUSSION: Simvastatin showed a significant antimicrobial effect against MSSA (mean MIC 29.2 mg/L) and to a lesser extent against MRSA (mean MIC 74.9 mg/L). Fluvastatin had a significantly less marked antimicrobial effect. Propranolol showed no antimicrobial effect. Simvastatin has a considerable antimicrobial effect in vitro and further testing of it is warranted.

Red

Hmmmm, very interesting...Thanks for posting this!

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This one is so important as statins have been used in treating MS for "unexplained" reasons, usually attributed to their anti-inflammatory effect. Similarly, how much of the lowered risk in cardiac disease is due to the anti-bacterial effect of statins vs their cholesterol effect? Of course, denying cholesterol to Cpn inclusions also fights the Cpn (according to the science on delta-tocotreinols).

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

 

Gosh, all those people who are using statins as a treatment for their MS are maybe doing more for it than they thought.  There's a forum for statins over at ThisisMS.  Guess where I'm going now!.............Sarah

An Itinerary in Light and Shadow

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.
Red

Go Sarah!

You know, I know I'm probably more than a little biased, but given the evidence of infection with the diseases that some statins seem to help and given that people don't seem to get worse with statin treatment (which you might expect if they just had anti-inflammatory effect), you kind of had to figure some of the statins (not all seem to work) have antimicrobial qualities.

BTW, similar studies suggest that simvastatin, reduces the incidence of Alzheimer's disease and Parkinson's disease by almost 50 percent:

Specific Statin Significantly Reduces Alzheimer's And Parkinson's Disease Risk, Study Shows

Unfortunately research on many of the other statin class drugs cloud the findings, but combine the above with research that suggest that some of the statins have a direct effect on Cpn growth:

Effect of Simvastatin, an Established Lipid-Lowering Drug, on Pulmonary Chlamydia pneumoniae Infection in Mice

Effect of pravastatin treatment on Chlamydia pneumoniae infection, inflammation and serum lipids in NIH/S mice

And, from a common sense standpoint (if not a medical one), it all seems pretty clear...

 

 


 

 

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

To add to the picture, here's a review article saying that, with all the big studies that have been done on statins, nobody has actually proven that they work by lowering LDL cholesterol, and that they might have other mechanisms of action which are responsible for their lowering the death rate (which at least some of them have been pretty definitively proven to do).

I had a look at the full paper. The antimicrobial effects it reports are, by the authors' computation, only present at concentrations about three orders of magnitude above what people normally take. They say some things about there possibly being more accumulation of the drug in the elderly, and such; but one can't get three orders of magnitude out of effects like that.

Normon- One factor might be that the anti-Cpn effect is not based on having a direct antimicrobial effect, rather that it denies cholesterol to EB's attempting to invade cells via lipid-rafts and form inclusions. No cholesterol, no inclusions. This is the same way in which the delta-tocotreinols, which also lower LDL, appear to work. So it's effect is more from limiting invasion of new cells and infected cell attrition.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral