Submitted by mrhodes40 on Mon, 2005-10-17 20:31

CPn and Cardiovascular Issues -

Statins and CPn

Persistent CPn infection of cardiomyocytes associated with acute MI

Atherothrobotic events and CPn Long term study on CPn IgG and IgA findings in atherothrombosis

Higher incidence of persistent chronic infection of Chlamydia pneumoniae among coronary artery disease patients in India is a cause of concern.

CPn and atherosclerosis Article which is in depth and includes many interesting diagrams and pictures. An overview of the understanding of the role CPn plays in cardiovascular issues with many links in the work

Experimental Chlamydia pneumoniae infection model: effects of repeated inoculations and treatment This article is about mice repeatedly infected with CPn and the impact on the cardiovascular system. luteolin in mentioned.

The role of endothelial dysfunction and Chlamydia pneumoniae infection in patients with ischemic stroke Intimal thickness is a measure of atherosclerosis this research correlates it with CPn seropositivity

Cpn in heart disease Think all this research is done by one or two people? Not at all. This link out highlights work done in Seattle on several cryptic organisms in CFS.

Doxycycline use and incidence of CAD This retrospective study of clients in a Greek cardiac practice reviewed use of doxy and later incidence of CAD. A reduction was seen.

The CDC on CPn The centers for disease control recognizes CPn as an emerging issue in atherosclerosis and other diseases. Once again CPn is becoming more recognized in chronic illness traditionally thought "autoimmune"

The Influence of CPn on aortic stiffness in healthy young menIs CRP a response to CPn in cardiovascular issues? C reactive protein and pulse wave velocity measurement of stiffness were both statistically higher in the IgA positive group for CPn.

Antibodies to 60-kilodalton heat shock protein and outer membrane CPn in people with CAD (coronary artery disease) Again, if you have CAD you have antibodies to the various proteins of CPn.

Autoimmunity to human heat shock protein 60, CPn infection, and inflammation in predicting coronary artery riskAutoimmunity plays a role in CPn infection

Antibody respose to Chlamydial heat shock protein strongly associated with cornoary artery disease HSP's are a contributing factor in CPn disease in study after study.

Serological evidence of CPn LPS antibodies in atherosclerosis of various vascular regions There are several proteins associated with CPn tht are immunogenic.

Chronic CPn infection associated with serum lipid profile known to be a risk for CAD CAD is coronary artery disease

Elevated antibody levels against Chlamydia pneumoniae, human HSP60 and mycobacterial HSP65 are independent risk factors in myocardial infarction and ischaemic heart disease. How have we missed this for so long?

Synergistic effect of persistent Chlamydia pneumoniae infection, autoimmunity, and inflammation on coronary risk. Several factors at work accounting for the research into other risk factors.

Chlamydial and human heat shock protein 60 homologues in acute coronary syndromes. (Auto-)immune reactions as a link

Effect of chronic Chlamydia infection with non-specific inflammation on cardiovascular complications in acute myocardial infarct

Azithromycin for the secondary prevention of coronary events Azithromycin alone, a bacteriostatic agent, is incapable of ridding the body of CPn. The EB's are not touched by this drug, the cryptic and peristant forms are encouraged, and it's bacteriostatic nature means the bacteria simply stop actively replicating and metabolizing until the coast is clear. You cannot create any meaningful research into this subject until you account for all lifecycle forms. We are essentially dealing with a form of resistance here. The conclusion of this study was that azith did not decrease coronary events.

Effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on Chlamydia pneumoniae in a continuous-infection model This paper finds that treatment with standard chlamydia effective antibiotics does not eradicate persistence. This highlights the need for combination and very long term treatment if one wishes to eradicate CPn.

Azithromycin therapy in patients with chronic Chlamydia pneumoniae infection and coronary heart disease: immediate and long-term This one indicated a possibly positive outcome on fibrinolysis though again the azith did not impact CPn positivity. Taken with the abstract above we have a situation that is confusing to the clinician - until you understand the pathogen and it's lifecycle. Then these studies are clearly incomplete and therefore inconclusive.

The final report on the ROXIS study This paper outlines the ROXIS study on roxithromycin use in patients who had experienced an acute non q wave coronary problem. The folow up reposts a positive effect. This links to the whole citation.

Effect of Treatment for Chlamydia pneumoniae and Helicobacter pylori on Markers of Inflammation and Cardiac Events in Patients With Acute Coronary Syndromes
Another antibiotic study with positive results though serologic markers of CPn and H pylori were not affected by treatement. It might be suggested this means it was some other aspect of the abx that influenced the disease (ie antiinflammatory) but since persistent CPn is not reflected in serologic markers it is likely moot. The whole citation is linked here.

Heat-shock protein 60-reactive CD4+CD28null T cells in patients with acute coronary syndromes We can certainly recognize how that crafty CD4+CD28 combo from MS shows up in this cardiac study and also in RA, somehow researchers from different fields don't seem to recognize them yet as possibly caused by the same source CPn, not autoimmunity.

Fulminant carditis and CPn This is a case of carditis that turned out to be CPn and CP together.