Niacinamide why is it used and how does it help?

Submitted by horses12 on Sat, 2009-10-24 08:29

   Has anyone used Niacinamide?  I heard it can help with poor circulation. Would like to hear from anyone who has used it and it's effects.


Hi Bonnie.... Niacin  is one of the  supplements recommended on the list to also counter endotoxin reactions:

 Niacinamide is the form of niacin that circulates in the bloodstream. Niacinamide is utilized by all body tissues to synthesize nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), the active forms of niacin. NAD and NADP are essential for over 200 enzymes and function as a hydrogen donor or electron acceptor (important for the synthesis of energy - ATP). NAD is also involved in the activation of folate and regeneration of reduced glutathione. Niacinamide and niacin are the two forms of Vitamin B3. Niacinamide does not cause flushing or skin irritation

Supplements Supportive to Counter Endotoxic Reactions



Mode of Action




500- 2000mg (with liver monitoring) spread over day or via time release.

Counters niacin depletion by Cpn. Assists in production of anti-Cpn bioagents. Counters endotoxin reactions.. Helps with chronic headaches.

Counters coldness reaction from endotoxin.

Lowers cholesterol (espec. LDL).

Causes flush reaction. Must work up slowly.

Can be liver toxic if other compromises to liver especially in time release. Should have liver monitoring at high doses.

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

I take niacinamide occasionally.  I have found that it needs to be combined with the other "metabolic" B vitamins, B1/B6 and B2/B5, or I get peripheral neuropathy (same with niacin).  I take 50-100 mg per day of B1/B2/B3/B6 and 500 mg per day B5.  I think this is a good level for general health.  Therapeutic doses, you have to listen to your body, but I would not recommend them for circulatory issues.

Circulation can be helped immensely with a low-carb paleo style diet -- remove grains, control carb calories to 400-600 per day (rice, potatoes, fruits/berries are good sources), no wheat or corn or oat products, plenty of meat and fats.  Also try 2500 IU/day vitamin D3, 200 mcg/day vitamin K2, and 2 gm/day vitamin C, and make sure your thyroid level is optimal (TSH = 1.0).

Blogger at 17-year chronic illness cured with diet and antibiotics, nearly fully recovered.

Some here take niacin to kill cpn in white blood cells.

There are old posts about it.

Best Wishes, Maria

Cpn since sep 2006. Autoimmune thyroid,hypofunction.levaxin,b12+folic acid.All classic cpn,porphyria and toxinsymtoms.Not able to work.Selftreating cpninfection with AllicinMax(garlic), NAC, high vitamin D3. CAP for over 3 years. Back to work and life