This abstract got me thinking again about things needed, not on the regular supplement list, to enhance our bodys fight against Cpni. Before my Cpn was diagnosed I was also tested for Natural Killer cell (NK) function and was found to be low, a common finding in Chronic Fatigue. I was put on an expensive supplement for improving this which seemed to do little by itself, and I let all that go when I focused on treating Cpn. As I'm keeping my eye out for what will give me the boost to get this last 20-25% improvement in my illness, this comes back to mind as perhaps a missing element in my supplementsi, there being a number of NK cell enhancer supplementsi available now.
- Am J Respir Crit Care Med. 2008 Oct 1;178(7):745-56. Epub 2008 Jul 2.
-
Natural killer T cells are critical for dendritic cellsi to induce immunity in chlamydial pneumonia.
Laboratory for Infection and Immunity, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
RATIONALE: We previously showed an important role of natural killer T cells (NKT) in skewing the adaptive T cell immunity to Chlamydia pneumoniae (Cpn), an intracellulari bacterial lung infection, but the mechanism remains unclear. OBJECTIVES: To investigate the underlying mechanism by which NKT modulate T cell responses in chlamydial pneumonia. METHODS: We examined the effect of NKT activation in modulating DC function, especially in generating protective immunity against Cpn infection using combination of NKT knockout (KO) mice and specific NKT activation approaches. MEASUREMENTS AND MAIN RESULTS: We found that NKT activation in vivo after Cpn infection induces phenotypic and functional changes in dendritic cells (DC). DC from NKT-deficient mice showed reduced CD40 expression and IL-12 production, whereas enhancing NKT activation using alpha-GalCer increased CD40 expression and IL-12 production. Co-culture of DC with NKT enhanced bioactive IL-12p70 production by DC in a CD40L-, IFN-gamma-, and cell-cell contact-dependent manner. Further, co-culture of T cells with DC isolated from infected wild-type (WT) and NKT-deficient mice induced type-1 and type-2 responses, respectively, while DC from alpha-GalCer-treated, infected mice led to enhanced type-1 responses. Moreover, upon adoptive transfer, DC from infected WT mice induced strong type-1 immunity, whereas those from knockout mice induced type-2 responses and increased disease severity upon challenge infection. CONCLUSIONS: Our results provide direct evidence of the critical role of NKT activation in the functional modulation of DC for the development of protective immunity in a clinically relevant respiratory infection.
___________________________________________________________
CAPii for Cpni 11/04. Dx: 25yrs CFSii & FMSii. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tiniii 1000mg/day pulses; Vit D2000 units, T4 & T3
Hah! They have NO idea how
___________________________________________________________
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi
Well, that might explain
Well, that might explain why only a few people develop CFS/CFIDSi from a fairly ubiquitous bacteria. If you have enough good NK cells, it is just a "cold", but if not, you get rosaceai or RAi or CFIDSi, depending on other factors.
I think MSi is in a class by itself, so I didn't include it in that list. I wonder about NK cells and MS, but don't remember anything offhand.
Now, Jim, are you going to divulge the NK cell supplement? Expense is an issue, but I'm curious. Like you, I'm suspecting that there will be some collateral damage to repair even after the CPni are gone.
___________________________________________________________
Ron
On CAPi for CFSi starting 01/06 (NE Ohio, USA)
Currently: doxyi & zithi -- continuous; metronidazolei -- 5 days on, 9 days off.
Get the research results you paid for: support Open Access
Exercise increases NK
Exercise increases NK Killer Cells as well as Nitric Oxide levels. Some of us have trouble exercising but meditation and Yoga also increase NK cells.
http://www.cnn.com/HEALTH/alternative/9906/22/meditation/
Om......
Raven
___________________________________________________________
Feeling 98% well and going for 100! Still testing + for Cpni since June '08.CAPi since 8-05 for Cpn and Mycoplasma P. for MSi and/or CFSi. Also EBVi and HHV6 NACi, Iodoral, T3, BHRT, Methylcobalamin injections, Nitro patch, LDNi and Methylation supplementsi
Ron- It's been such a long
___________________________________________________________
CAPi for Cpni 11/04. Dx: 25yrs CFSi & FMSi. Currently: 150mg BID Roxithromycin, Doxycycline 100mg BID, Tinii 1000mg/day pulses; Vit D2000 units, T4 & T3
Om to you, too, Raven!
___________________________________________________________
The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi