Maximouse, with her pink ear tag indicative of sustained flagyl, has had to switch places with Minimouse wearing a blue one indicative of fall back to less flagylation.
I'm feeling a bit sheepish (or maybe mouseish) after high hopes of improving the rate of die off and speed the recovery a bit along the way, but after taking 400mg of metronidazole daily for 6 weeks (with a 5 day pulse of 1200mg in the middle) I have had to give my poor liver a break for the past week.
Pulse 17 brought quite strong reactions, but abated quickly and I was able to continue taking the metronidazole with minimum side effects, pulse 18 escalated the die off and I was feeling the full effect of the extra metro within 12 hours of starting the higher dose, and felt quite ill for the duration of the pulse.
Post pulse 18 porphiric symptom abated somewhat, but the irritated oesophagus, skin flare ups, the loose bowel movements and the copper coloured urine stayed with me, in spite of the charcoal and careful eating and drinking.
In the light of the recent discussion between Basil, Red and Jim, the explanation that there might be a vicious porpyric circle, makes sense to me. I was thinking that I seemed to be stuck in a situation that was not improving and that I needed to give my liver a rest. The explanation that Basil and Jim provided fits with my experience. A couple of days after stopping the flagyl, my oesophagitis abated dramatically and the urine has returned to a more normal colour, my gut feels healthier and my skin lumps and bumps have lost their angry look.
So maybe it was a bit too soon for me to go down the continuous flagyl even at the lower doses that I was taking. For the time being I will go back to: 5 day pulse of 1200mg, 9 days off flagyl, 7 days on 400mg, before starting another pulse. This seemed to work before and maybe I can start doing continuous flagyl in a couple of months time.
My increased Flagylation has had results in terms of improvement though: I have definitely felt some changes in places that had not been addressed before, especially in my lower abdomen and my legs and feet, and I have felt well enough since stopping the continuous flagyl to go back to my exercise programme at the gym and take a daily stroll in the spring sunshine.