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Mult Scler. 2008 May;14(4):564-6

Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis.

Contini C, Seraceni S, Cultrera R, Castellazzi M, Granieri E, Fainardi E.

Section of Infectious Diseasesⁱ, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy. cnc@unife.it

The presence of Chlamydia-like organism DNA was investigated by polymerase chain reaction (PCRⁱ) in cerebrospinal fluid (CSF) samples from 27 patients previously found positive for Chlamydia pneumoniae DNA: 12 with multiple sclerosis (MS), grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity, 8 with other inflammatory neurological disorders and 7 with non-inflammatory neurological disorders. PCR evidence of Chlamydia-like organisms in CSF was observed only in two relapsing-remitting MS patients with clinical and MRI disease activity. These findings suggest a possible association between C. pneumoniae and Chlamydia-like organism brain infectionsⁱ as a cofactor in MS development.

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CAPⁱⁱ for Cpnⁱⁱ 11/04. Dxⁱⁱ: 25yrs CFSⁱⁱ & FMSⁱⁱ. Currently: 250 aithromycin mwf, doxycycline 100mg BIDⁱⁱ, Tiniⁱ 1000mg/day pulses; Vit D2000 units, T4 & T3, 12mg Iodoral