Metronidazole carcinogenic ?

I don't know if the topic was discussed already...

Metro has a black box label and may be carcinogenic (I know you've heard that already). The most actual review I found was from 2002: https://www.ncbi.nlm.nih.gov/pubmed/12052431<

The abstract sounds pretty serious to me, but I have to get the whole article and work through it. It seems that there are no good epidemiologic studies up to now. So you might get the feeling some people don't want to know the real risk. After all, metronidazolei is on the market for at least 50 years.

What do you think? I'm very concerned about this and will stop therapy until I have more information.

You might want to read this thread. http://www.cpnhelp.org/carcinogenic_metronidazol <

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

i have just tried to look at the link but it comes up as ' page not found'

MSi Diagnosed 07/03/05, copaxone Jan 2011 to Jan 2013, started doxyi 13/10/12, started roxyi 06/11/12, increased doxy 28/11/12. first metroi pulse 01/01/13. Tinii Dec 2014. Fampyra,B12,Vit C,Vit D3,Vit E,Vit K2, NACi,ALA,AcetylL-Carnitine,Fish oil,

That's weird, but it happened to me, too, when I clicked on it just now.

Okay, try this.  Go to google, type in "metronidazolei carcinogenic cpni " and it should be the first result at the top of the page. 

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

thanks Mack i found it and realised i have read it before.

MSi Diagnosed 07/03/05, copaxone Jan 2011 to Jan 2013, started doxyi 13/10/12, started roxyi 06/11/12, increased doxy 28/11/12. first metroi pulse 01/01/13. Tinii Dec 2014. Fampyra,B12,Vit C,Vit D3,Vit E,Vit K2, NACi,ALA,AcetylL-Carnitine,Fish oil,

It's really important to be informed but, quite honestly, I trust the capi and, for me, the risk of cancer is less worrying than the certainty of debilitating MSi. But, this is good to know, so thank--you!

To my mind, people misreading statistics comes into play here: metronidazolei would have been taken off the market years ago if it had been found to drastically increase the risk of someone developing cancer. It is one of the antibioticsi which you are not allowed to feed to non-organic farm animals, because of the risk both to the animals and the people who might eat them, especially those with a serious hamburger habit!

I was thinking about this the other day: the vast majority of people die peacefully at home, from old age.  The thing is, this is not headline news.

One thing to think about here, is that if you pulse metronidazole for five days on, then one month off or longer, it is not the same as taking the stuff full-time and long-term..................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I just stopped my pulses with Metroi because of this to. But maybe the fear to take it plays bigger role than the antibiotic itself.. I think the fear to take it it's the bigger cancer trigger than the medication itself. Might be.

Success is journey not destination

I assume all of you are switching to tinidazole?

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

This would make little sense, as tinidazole is probably not a better alternative than metroi (same class of substances).

In my view, the best thing is not to worry about it maybe being carcinogenic, especially if you pulse it.  Besides, chlamydia pneumoniae is thought to be one of the causes of lung cancer, if you look it up.........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MSi in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

I wasn't aware tinidazole had a warning attached to it, Markus83? 

(Regardless, I used metronidazolei for seven years, pulsing, on the protocol.  Twice, I used it nonstop for a month each time.  i've had no issues.) 

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

I couldn't find anything in the literature about tinidazole and cancer risk. On Metro there is a bit, but certainly not enough to draw any conclusion. The development of cancer is often a lengthy process of 20 or 30 years. So it makes little sense to look if there is a higher cancer incidence 2 or 3 years after metronidazolei administration (as has been done in one study).

Another study (woman with 500 - 750 mg metronidazole per day for 10 days, either as oral tablet or vaginal suppository) found a statistical significant 2.5 increase in bronchogenic carcinoma 15–25 years after exposition to metronidazole. Keep in mind that a vaginal suppository is not the same as an oral tablet, because the latter gets absorbed nearly completely while a suppository gets absorbed to maximum 20%.

If you are severly ill and Metro or Tinidazole helps you - ok. It also depends on how old you are. It makes a huge difference if you are in the twenties or sixties. Someone in the sixties will probably die of another cause before he/she develops cancer as a result of metronidazole use.

Keep in mind: I'm not arguing from the perspective of a MSi sufferer, because I don't have this disease. If I would be wheelchair bound, I think I would consider taking the drug, at least for a few pulses to see if it helps me. After all I have taken metronidazole/tinidazole for together 20 days. But I would need to take the drug continuously 4 weeks in a row or so to get substantial benefit. And this risk I don't want to bear.

Even if cancers are lengthy processes, once a risk factor is removed, the increased risk from it generally decreases with time, and not the opposite, as you surely know but choose not to mention in this overview. That cancers develop over decades is probably much from that risk factors remain; the creatures of habit that we are.

Regarding the article on cancer risk from Metro in vaginal trichomoniasis (guessing you refer to Beard, et. al.: "Cancer after exposure to metronidazolei.", Mayo Clin Proc. 1988 Feb;63(2):147-53"), how was somking measured? What other risk factors were adjusted for, and how were they measured? As you surely know, quite a bit of traps in such study design have been recognised since the 1980's, not to speak of since the 1960's when data was first collected.

You only mention speculative risks with the the treatment, but fail to mention the definite, and the very likely risks of the Cpni-related illnesses, i. e. the risks of not treating.

Borrelia/Cpni arthritis: joint, skin, eye, CNSi, respiratory, UG involvment; fatigue. Borrelia Elisa&WB IgGi, and CPn IgG and IgA pos, HLA-B27 neg. CAPi 5/9/2010 -> 3/2016 2017: some signs and symptoms returning, Borrelia?

Several years ago I treated a 13 year old girl diagnosed with an anaplastic large cell lymphoma. It was well advanced at presentation. A C. pneumoniae specific IgAi Elisa was morbidly raised (SeroCPquant: Savyon Diagnostics, Israel). She died shortly after treatment was begun.

 

It makes sense that C. pneumoniae should make conditions ideal for the proliferation of malignant cells. One of the host defenses against malignancy is the apoptosisi of cells undergoing malignant change. C. pneumoniae prevents host cells from suicide by interfering with the caspase pathway.

D W - [Myalgia and hypertension">i (typically 155/95.) Began (2003) taking doxycycline and macrolide and later adding metronidazolei. No medication now. Morning BP typically 110/75]

"Even if cancers are lengthy processes, once a risk factor is removed, the increased risk from it generally decreases with time, and not the opposite, as you surely know but choose not to mention in this overview."

I had the atomic bombings of Hiroshima and Nagasaki in mind. As far as I know maximum cancer incidence occured about 10 years (or so) later for leukemia and even later for solid cancers. And I think there hasn't been a prolonged exposition to radioactive radiation; it was a one time event. But it's true that if a smoker stops smoking after 10 years or so his cancer risk drops to normal values.

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