Methylation block.

Does anyone have information along the lines of

"Methylation Block for Dummies"   and how it relates to chronic infection.

As soon as I see those spaghetti diagrams, my brain goes in a cramp.

I need an easy to digest explanation......please ! 

Do an internet search for Rich Van Konynenburg and some part of the title of the article "...Glutathione Depletion - Meythylation Cycle Block Pathogenesis Hypothesis...". 

Rich is a PhD, not an M.D. and he's dealing with CFS, not MS, but if we believe CpN causes both, the treatments should have similar effects.  I have not tried anything he suggests other than switching my vitamin B-12 supplement from cyanocobalmin to methylcobalamin.  Some days it seems to make a difference, other days it doesn't, so I don't know if there's anything to it, but the paper is reasonably understandable by a layman.  Whether anything it says is true is another matter.


CAP for M.S. 8/2007 - 3/2009.  Twentieth pulse metronidazole + INH completed 3/12/2009.  Intermittent treatment thereafter until 11/20/2009.  

You might also want to peruse what has been bookmarked in the "Forums" section here.


JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

I know that Dr. Powell suggests hydroxycobalamin.  That form of B12 often makes my shoulder/neck pain (the area where much of the infection seems to have settled) much worse for about an hour after taking 2000 mcg sublingually. 

Started CAP for Cpn on 11/14/10 - Per my doctor, paused Abx 5/18/13 - NAC, T3, St Johns Wort, B-complex, Vit C, Vit D3 (8,000/day), Vit E, Astragalus, Chlorella, Chelation with Alpha Lipoic Acid. Started Buhner protocal (2nd edition) on 8/30/16.

I have been following Rich Van Konynenburg's simplified protocol for about three years now and have gotten improvement (about 30%)

I think improving my methylation cycle helped my body fight chronic infection and probably alot of other stuff too

I got to a point where I had plateued so I started seeing a specialist and am now addressing Cpn 

The abx protocol is working very well so far 

DAILY:  NAC 2400MG , DHEA sublingual , vit D3 , multi vits,./ Three times  a week: B12 injections (Hydroxycobalamin). Deer antler./  Once every few months methyl B12 Methyl injections