"Mast Cells" - and MS, Mast Cell Activation Syndrome and CRPS
Rick's Doctor treating him for CPN, forwarded the following to Rick today. It appears at the least to support the idea of using an Antihistamine to prevent demyelination, and perhaps to help with promoting remyelination. See the last couple of paragraphs of the post (not the articles) for how this might be related to CPN and it's treatment.
Multiple sclerosis (MS) lesions are associated with infiltration of T lymphocytes and macrophages that appear to mediate myelin destruction and gliosis (scarring). Mast cells are located perivascularly in the brain, are juxtaposed to neurons, and have been shown to secrete vasoactive and inflammatory mediators in response to neuropeptides and direct nerve stimulation. Mast cells have been previously identified in MS lesions, are activated by myelin basic protein, and can participate in the regulation of blood–brain barrier permeability, as well as in myelin destruction. Here, cerebrospinal fluid from MS patients and controls with other neurologic diseases was assayed for histamine, its major metabolite methylhistamine, and the specific mast cell marker tryptase. Histamine and methylhistamine were not elevated in MS. However, the mast cell specific proteolytic enzyme tryptase was significantly elevated in MS, suggesting that mast cell activation may be involved in the pathophysiology of this disease.
The above was posted here:
Additional information the good Doctor sent included:
This is supportive of the idea of adding an antihistamine to assist in speeding up remyelination - and the Doctor has also recently both mentioned the role of Antihistamine for helping Rick and may have reviewed the information I sent him and discussed with him in my recent meeting with him as a new patient to treat CPN.
That information is really mostly from this post:
I may add this information to that post as well.
So - as to Rick's recent efforts and progress:
It's very early to suggest that his recent (2 weeks) clemastine addition has anything to do with this. Rick has only just started the clemastine, and only started for the first time in several years - a regular, disciplined and consistent exercise program. Will power and desire are likely a big part of what we've seen.
That, and an increasingly strong belief that he's no longer fighting a losing battle, e.g. that nothing he could do would make any difference so why bother trying. I believe his recent efforts are based on that change in outlook he's been increasingly internalizing, and at least partly on the same time-table my confidence has been increasing. We are very close to or over halfway through his regularly scheduled time of year (January to late March) to have a serious relapse - and - NONE!
So - he's been working on standing up and down, from his bed or his wheelchair - with a walker and someone to assist, for 2 weeks now. Yesterday, and for the first time in quite some time - he was able to lift a foot and move it a bit - 3 inches I heard from him and his brother Chris last night. It's a small "step" - but the first one he's done in some time...
Interesting set of articles above - and more information about how Histamines could play a huge role in at least some cases of MS. I'm curious about the possibility of CPN playing a role in causing inflammation in the brain - leading to Mast Cells releasing Histamines and fouling things up for Oligodendrocytes. Apparently, histamines are part of Mast Cells and easily released. See the article for more details on that. Clemastine is a very special Antihistamine given it's other mode of action - e.g. turning the "on-switch" in Olidgodendrocyte Precursor Cells, causing them to mature into Oligodendrocytes and to proliferate through the brain and reymyelinate axons. Clemastine does that through it's "anti-muscarinic" M3 metabolic pathway. For those details - see the forum post I mentioned above - and again here: http://cpnhelp.org/ms_cap_protocol_variation.
I mentioned the last part to be sure the dots are connected for folks as to how this post might relate to the more general subject of CPN treatment and may not be just related to MS. Another connection that folks may find in the articles - is through Fibromyalgia sorts of symptoms.
Anyway - all that said....
My Best & Highest Regards to all!