Josamycin - The better Macrolide?


 I just sumbeled over this study and wondered if anyone has tryed Josamycin?


The summary (also in english if you scroll down a bit) says that effuxpumps of streptococci cant pump it out other than other macrolids. as far as i remember from pauls posts cpn uses effuxpumps as resisntance mechanism. so maybe it works for cpn effuxpumps too?


has anyone tryed josamycin for cpn tratment? i also wonder if its as good for long time use as other macrolides?









it will be interesting to see what the 'medical minded' people have to say about this..

Mphs, TN. CFS, hypoT (Hashi), adrenal fatigue, hormonal inbalance. right arm neuropathy-getting better. cpn, myco, EBV, CMV, HHV-6. Cap began in 6/07. NAC 2400mg, mino 100mg bid, biaxin 500mg bid. cytomel, flagyl bid continuously.

I'm not medical minded, LOL, but from what I could interpret from the link, it doesn't apear to target Chlamydia pneumoniae.....but assuming it would still work?

von Josamycin

Gram-positive aerobe Pathogene
Staphylococcus aureus, Staphylococcus epidermidis,
Staphylococcus citreus, Streptococcus pneumoniae,
Streptococcus pyogenes, Corynebacterium diphtheriae
Listeria monocytogenes

Gram-negative aerobe Pathogene
Bordetella pertussis, Haemophüus influenzae,
Neisseria meningitidis, Neisseria gonorrhoeae,
Treponema pallidum

Anaerobe Pathogene
Bacteroides fragüis, Bacteroides spp, Peptokokken,
Peptostreptokokken, Clostridien

Intrazelluläre Pathogene
Mycoplasma hominis, Mycoplasma pneumoniae,
Ureaplasma urealyticum, Chlamydia psittaci,
Chlamydia trachomatis, Legionella pneumophüa,

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

oops, i missed that.
seems to work less effectively than smaller macrolides in this study:

C. pneumoniae was susceptible in vitro to midecamycin diacetate with an MIC of 0.5 mg/L. This activity was similar to that of josamycin (MIC 0.25 mg/L), another 16-membered macrolide, but lower than those of the 15- and 14-membered macrolides, azithromycin (MIC 0.125 mg/L), erythromycin (MIC 0.05 mg/L), roxithromycin (MIC 0.03 mg/L) and clarithromycin (MIC 0.012 mg/L), as described previously.5 Midecamycin diacetate seemed to be less potent than telithromycin against C. pneumoniae for which a MIC90 of 0.06 mg/L has been obtained.6 However, the midecamycin diacetate MIC for C. pneumoniae of 0.5 mg/L, is below the breakpoint (1 mg/L).


(did they miss a zero for azithromycin?)

 but on the other hand its taken in higher doses: 1500 mg is the dayly standard dose.


and the study doesnt target the resistance issue........




07/2010 Roxi 150 bid, Doxy 100 bid,Metro Pulses,Nac 1200 bid,Vit D3 + Suppl.

34Y,CF-IDS, IBS-B (SBBO) >low weight,slight fibromyalgia,chest pain,very cold limbs and sinusitis since 1999,chronic but slight Epididymitis/Prostatitis>2010