Here's an article on a study linking IL-1beta, from H. pylorii infection, with the initiation of cancer via IL-1beta's mobilization of Myeloid-Derived Suppressor Cells (MDSCs):
ColumbiaSpectator: CU Researchers Make Cancer Discovery
"Following up on evidence from previous research, Wang’s team had a hunch that a single cytokinei, called IL-1β, might be involved. They infected mice with a bacterial cousin of H. pylori, but also gave the mice a drug that specifically counteracts the effects of IL-1β. Sure enough, these mice did not develop stomach cancer. Researchers also used genetic engineering techniques to create mice whose stomachs released excessive amounts of IL-1β. The researchers saw that these mice had very high rates of stomach cancer, even in the absence of bacterial infection, further confirming the conclusion that IL-1β is a primary cause of stomach cancer.
On their own, these would be significant findings. Stomach cancer is the second most common cancer worldwide, so other researchers will soon follow up to see whether anti-IL-1β drugs could effectively treat the later stages of the disease, which are hard to tackle with conventional treatments.
But the researchers were also able to discover the precise mechanism by which IL-1β leads to cancer, and in doing so may have uncovered a wider link between the immunei system and cancer.
Wang’s team followed the trail of IL-1β to a mysterious type of immune cell known as the MDSC. “The MDSC, I thought, was one of the important links we picked up in this paper,” he said.
Scientists already knew that MDSCs betray the body by helping existing tumors grow larger. They help the tumor slide under the radar of the immune system, which would otherwise eradicate it. They also help the tumor feed itself by persuading the body to grow new blood vessels in the area. What Wang’s team discovered is that the MDSCs are involved in the early stages of cancer as well.
“We are the first group to really prove or show that they can probably play a role in cancer initiation,” Wang said. “So our paper was all about the beginnings of cancer—that is, there was no cancer, and then there was cancer.” And when the researchers looked at the early stages of inflammationi that would later lead to cancer, they saw that the MDSCs were there, present at the scene as the crime was about to occur."
Here's the actual study paper:
Of course, past studies have suggested that C. pneumoniae can also increase IL-1beta:
Perhaps with this research, the potential link between C. pneumoniae infection and the development of cancer is becoming clearer?
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Can someone explain this
Can someone explain this please.
Does it mean that cpni or high IL1 ( IL 1 beta is often elevated in people with cfs ) causes stomach cancer?
And is it likely to develop cancer from this awfull illness?
Please comment.
thanks
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Male 35 years (Hamburg-Germany),CFIDSi, IBSi, Enterovirus, Cpni for years positive. Started Capi on 02/19/08, Currently NACi 2400,
Doxyi 2x100,azi 500 each day,Doxy 200, tini pulses, Oral Vancomycin for c.diffHi Cesare,I wouldn't get to
Hi Cesare,
I wouldn't get to overly concerned about this. You've got enough on your plate right now worrying about your infectionsi!
For quite some time though, studies have suggested that inflammationi can lead to cancers, and in fact more and more studies seem to suggest that cancer creates and exploits inflammation itself to grow once it has become established.
The links to the study above on IL-1beta and MDSCs may just be adding some more details on how inflammation may lead to cancer - that is through IL-1beta and its effects on MDSCs. The study is on how H. pylorii infections may lead to stomach cancer though, not Cpni...
My point in the link to the study on Cpn in COPD is that Cpn infection too has been linked to high levels of IL-1beta, as have infections with other pathogens. So, IMHOi, those in the medical community who seem to think that a Cpn infection is common and harmless, should wake up to the potential that chronic Cpn infections, or chronic infections with any other highly inflammatory pathogen for that matter, may not be all that harmless after all...
Still, no need to get overly worried. You're treating your infections. Just keep up the good work, concentrating on one step at a time.
How is your C. diff treatment going? Have you thought of taking a goodly amount of Vit D3 while you are off CAPi for treatment of C. diff?
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Treatment for Rosaceai
Hi Red!Thanks for your
Hi Red!
Thanks for your explanation. I treated my c.diff. for 10 days now with oral vancomycin. Next week i am going to take the Rifaximin chaser. It is an oral very strong rifampin antibiotic which works only in the gut as a bleacher afterwards. I am scared abouit getting the c.diff. not under control. A lot of people who had c.diff. are scared to hell taking abxi again. But I have no choice. Another good reason when restarting the capi to take rifampin 600 p.d. on board , together with the azi. The rifampin should take care of cpni, bartonella and cdiff.
Cesare
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Male 35 years (Hamburg-Germany),CFIDSi, IBSi, Enterovirus, Cpni for years positive. Started Capi on 02/19/08, Currently NACi 2400,
Doxyi 2x100,azi 500 each day,Doxy 200, tini pulses, Oral Vancomycin for c.diff