27 Apr 2018

Interesting Study - FOXO proteins and immune function


 Hi all,In my usual, nerdy, fun-filled weekend morning reading of recent pubmed articles on inflammation, I ran across a study on FOXO proteins and their importance in healthy immune functioning.   I'd never heard anything about these proteins before, so I did some googling and came across some interesting studies that I thought I would post.    First, FOXO proteins are a subgroup of the Forkhead (FOX) family of transcription factors, and as the following article points out:


How interesting, Red. I will have to read more about it. Thank you.

Stratton/Wheldon protocol 02/2006 - 10/11 for CFS and many problems 30 years

Drat, just when I was heralding your return and you have to go deny me my cheese and butter. Okay, I'm willing to give it a go. Briefly. ;-)

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Looking at some of the references in that last paper, the IGF-1 changes from milk consumption seem rather small. IGF-1 has very large 'normal' ranges. (I always get suspicious when articles like this leave out the numbers.)

At any rate, if the whey fraction is the one containing the evil spirits, then cheese and butter should be just fine, since whey is what's drained from them in their making.

If you're looking to boost FoxO1, the sentence "It has been demonstrated that retinoids are potent inducers of FoxO proteins" seems like a better thing to fasten on. That's vitamin A and cousins.


Hey all,I'm roughly @ 10 days of trying my best to avoid dairy, and I've noticed that my skin seems to be less dry and prone to irritation and actually feels more "normal" than even before.   I've also noticed that my constant morning backache has gone away and even my eyesight seems to have improved - I'm on the cusp of needing reading glasses.   Dang you old age!  Tongue outI'm still noticing some odd muscle twitching, occasional aches and pains, and more sinus discharge, but nothing major.    I have to say I was a bit skeptical about this at first, but I'm definitely seeing enough health improvement that I'm thinking there really is something to this.    I'll definitely give this more of a go... Hope this might help someone else.   Hang in there...  

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Red, You might consider looking at your amounts of Omega-3 intake in regards to the flexibility of the lenses in your eyes and (even the effect on the skin) to hold off the reading glasses a bit longer perhaps.    I'd love to hear what you find when you research it a bit.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

That's an interesting connection, Red.  I haven't read a lot about FOXO, PI3K, or IGF-1, but I know that ketogenic diets have a strong positive effect on them.  See for example, 


and "The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma", http://www.nutritionandmetabolism.com/content/7/1/74 (Excuse the inconsistent formatting: I haven't quite figured out how to post links properly!)    

Treating bipolar II depression (in remission), mild rosacea.Therapies: Ketogenic diet, NAC, niacinamide, melatonin, D3, quercetin+bromelain.May start CAP after breastfeeding.