Infectolab Chlamydia pneumoniae Elispot LTT


Hello! Smile

I'm new to the forum (but not new to chronic illness...).  I've been unwell for just over 20 years with ME/CFS.  In that time I've explored various causes for my symptoms and tried the usual gamut of treatments, at least those that seemed rational at the time.  In recent years I've become hypersensitive to medications and supplements, so I've slowed down my turnover of treatments as many times I can't tolerate them.

Several years ago my doctor ran a panel of PCR tests and the only one that came back positive was Cpn.  I then did a treatment with Sulfoxime and Dioxychor infusions x 3 and retested twice.  The test reported negative both times, but I remained unwell.  From what I understand so far, it may be possible for there to be reservoirs of infection in deep tissue meaning a peripheral blood PCR may represent a false negative?

Last year I decided to investigate for Cpn again and we did the Infectolab Chlamydia pneumoniae Elispot lymphocyte transformation test.  The lab result was +14 (ref <2) and the report says the Elispot indicates cellular activity against Chlamydia pneuomiae.  How convinced would you be by this?  As a technology lymphocyte transformation tests are not universally regarded as reliable.  How does my result compare with other people's?

I've sat on this test result, in part because I don't fully trust the information and also because I don't relish the prospoect of a treatment protocol consisting of long-term antibiotics...  I've already taken quite extensive courses of antibiotics in my attempts to get better.  This includes several months of various antibiotics for putative Lyme disease.  There have also been long term antibiotics for acne and prostatitis.  I feel like antibiotics are the last thing I want to take right now.

Are there any effective treatment protocols that don't involve prescription antibiotics?

Another question that comes to mind is, what about the risk of re-exposure to Cpn?  It seems to be an infection that is commonplace in the community and easily aquired.  What if you go to extreme lengths to comply with a treatment protocol risking potentially harmful side effects, only to pick up Cpn again?


My suggestion would be to take the NAC test to see if you have a flu like reaction which would confirm CPN. If you don't want antibiotics you may want to investigate Buhner's herbal protocol or  Cowdens. Sphinx here did the Buhners protocol after CAP. There is a Facebook group Buhner Healing Lyme and Co-Infection group that you might want to check out:

for Cowdens to here:

In addition, this fellow knows a lot about LYME and co-infections. You can get in touch with him via his Facebook or website. He is very nice and helpful.


I was also tested by Infectolab. Both my MD and ND trusted their results. My results were positive for CPN and chronic LYME.

Here are my results for CPN for comparison:

Chlamydia pneumoniae antibodies

Chlam.pneum.-IgG-antibodies (ELISA)+ 1.9 Ratio <0.8=neg.;>1.1=pos.

Chlam.pneum.-IgA-antibodies (ELISA)+ 1.7 Ratio <0.8=neg.;>1.1=pos.

The specific Chlamydia pneumoniae-IgG- and -IgA-antibodies are an indication for an

actual humoral immune response against Chlamydia pneumoniae. Please look at the

Chlamydia-Elispot-LTT for the actual cellular activity.

Chlamydia pneumoniae Elispot LTT

Chlamydia pneumoniae-Elispot LTT + 5 SI < 2

The result of the Elispot-Lymphocyte-Transformation-Test (LTT) is an indication for

an actual cellular activity against Chlamydia pneumoniae.

Regarding risk of re-exposure (reinfection, to be specific), most of us plan to take N acetyl cysteine daily, for the rest of our much-healthier lives, to preclude cpn getting another foothold.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Quite, I take 1000mg of NAC most days and I haven't even had a cold this last thirteen years.........................Sarah

Completed Stratton/Wheldon regime for aggressive secondary progressive MS in June 2007, after four years, three of which intermittent.   Still improving bit by bit and no relapses since finishing treatment.

Thanks for your replies, I really appreciate it.  Lots to think about.  I'm trying to catch up with some reading at the moment and then hope to write more soon.

Not sure how best to organise information I post to the forum.  I think further posts will delve more into treatment options and past medical history, so that probably means starting a new thread in a different section of the forum.  I guess that makes sense, though it seems a shame to detach further information from that preceding it here giving some context and background.  I was even thinking perhaps I should have put this in the blog section of the website so it all stays together...?  But what I've written isn't exactly a blog either.

That's all for now.  Brain fog...