27 Apr 2018



I have Interstitial Cystitis and have been doing antibiotic therapy and the NP that I am have treating me wants me to take plaquenil to see if I have a die off reaction, I am currently taking ammoxicillin and augmentin and flucanzole for yeast.  Plaquenil has drug interactions with cymbalta which I am also talking. i am nervous to take it....Two years ago I took minocycline and rifampin and had horrible die off reaction and then for months I barely had any bladder pain or issues. then it came back again.  She is basing this on the Fry bug theory, she thinks I might have that.


Michelle,do you have a positive test for the Fry bug? The Fry bug is treated with mino or biaxin and plaquenil.In the biofilm of the Fry bug is very often also cpn. You probably have both. The Fry bug does more the ALS like symptoms and cpn probably the bladder. My private opinion. 

I am taking plaquenil, zithromax and flucanzole and doing well. I do have monthly die off but I have this with every combination of abx. It is when I stop reacting to meds that my doctor switches me up. The die off only lasts 2-4 days for me. I am always leary about starting a new combo. but it always has worked for me. Good luck.

5oo mgs Ceftin 2 x/day, 500 mgs Zithromax, 500 mgs 2 x tini pulses,100 mg diflucan, 4.5 ldn; Wheldon protocol for MS April, 2006 to May 2008. 2008 MRI shows NO NEW DISEASE ACTIVITY, 2012 MRI no new disease activity.