27 Apr 2018
Author
Tommi C
Title

"Mast Cells" - and MS, Mast Cell Activation Syndrome and CRPS

Body

Folks,Rick's Doctor treating him for CPN, forwarded the following to Rick today.  It appears at the least to support the idea of using an Antihistamine to prevent demyelination, and perhaps to help with promoting remyelination.  See the last couple of paragraphs of the post (not the articles) for how this might be related to CPN and it's treatment.

Comments

Very interesting to read that antihistamines may assist in speeding up remyelination!And awesome to read that Rick has Not relapsed and is able to move his foot!!!Thanks for posting this great information.All the best,Louise_C03-23-2013 start datePPMSi  - May 2009, working with Naturopath since 2009, taking listed supplement_s, plus LDNi 4.5 and L-Arginine Plus.[had CCSVI in 2011 - helped a little]-Doxyi 200 mg, Azithromycin 250 M-W-F & NACi 1000 mg.Tinidazole #16 - 1000 mg days FEB 20 thru 24 2015

Hi Louise,To be very specific - yes Antihistamines appear, from this Mast article above, to be helpful in general.  The other forum post, specifically on Clemastine, has information about Clemastine that points to it being perhaps the very best current antihistamine for the purpose of remyelination.To expound briefly, and knowing you may know this anyway, for the benefit of other future readers, clemastine fumarate - aka "Tavist" - the brand name folks may be familiar with, has two modes of action relevant to remyelination:1. The histamine H1 receptor antagonist pathway - aka "antihistamine" - which the MAST article posted above speaks to and2. The "anti-muscarinic" pathway.  Apparently, the precursor cells for Oligodendrocytes - the cells that are responsible for remyelination, have a "switch" that is normally turned off.  The muscarinic m3 pathway - is present on the oligodendrocytes and clemastine through that pathway turns on the switch that tells those precursors to mature into oligodendrocytes and to proliferate through the brain where they will hopefully then remyelinate axons.My apologies if this is at all repetitive.  And - at least on the surface, at least one other antihistmine than clemastine appears to be extremely closely related - benedryl aka diphenhydramine is in the same family, and also appears to have the anti-muscarinic effect.  What's being tested though in a clinical trial - at UCSF - is clemastine.  They also published the doseages being tested for - 8mg a day.  Someone trying benedryl or another antihistamine may not have as much information to go on as is available for clemastine.One more bit to this - the UCSF phase 2 clinical trial was initiated after a "highly advanced, high speed image based screening method" was used to screen over a thousand different drugs already FDA approved.  8 drugs all stood out - with clemastine showing the most benefit.So, while clemastine is many times more expensive than benedryl (10x - 50 cents a pill vs. less than a nickel for a benedryl) - we know more about clemastine specifically in this context.  At retail pricing in the US for private labelled versions (Wal-hist for example from walgreens) - and at the full 8mg a day dose - the monthly cost is likely around $150.  Someone on a very tight budget could do a trial of benedryl -- afterall it's used as a sleeping aide for gosh sakes - I suggested Rick go with Clemastine instead for the above reasons.Again - my apologies for being so thorough - but I think it's important to point out the distinction between antihistamines in general and clemastine as a specific anithistamine with it's very specific ratios of antihistamine and anti-muscarinic effects.My very Best & Highest Regards to all!Tom C

Proud Parent of Rick - R started CAP in Nov. 13. Small measurable improvements as of 7/14, more by 10/14.  Holding Steady in early 2017.  "I will leave no stone unturned, no theory unexamined, to help my son." Tommi