hdwhit 22 Jul 2020 06:03 pm Die-off vs. MS Exacerbation I can only comment from my own experience, but when I had an MS exacerbation, I lost some function I that previously had worked (i.e. I would go to bed able to see color and wake up not being able to see color). On the other hand, a few days after finishing a pulse, I would start to feel, well, like I was hung-over from drinking too much. I would have Nausea, Aches and Pains, Malaise, Loss of Coordination, but I would not lose bodily functions. The Cpn Handbook discusses a number of things to aid the body in getting rid of the endotoxins. For me taking charcoal capsules provided some relief, but bile-acid sequestrants like Wel-Chol were much more effective at getting me through the die-off and back to feeling normal. CAP for M.S. 8/2007 - 3/2009. Twentieth pulse metronidazole + INH completed 3/12/2009. Intermittent treatment thereafter until 11/20/2009.