Importance of Vitamin D - in short

Red

 

Recent studies suggest the importance of Vitamin D3 in immunity, and indeed, vitamin D3 deficiency has been linked to multiple sclerosis, rheumatoid arthritis, hypertension, heart disease, depression, diabetes, chronic pain, osteoporosis and many other illnesses:

The Vitamin D Epidemic and its Health Consequences

Vitamin D3 has also been shown to play an important role in host defense against pathogens by promoting the production of the human antimicrobial peptides, cathelicidins (LL-37). These cathelicidins have been found to have broad spectrum antimicrobial activity, showing activity against the following microbes, among others:


While cathelicidins (LL-37) have been shown to have little or no direct effect against C. pnuemoniae, Vitamin D3 has been shown to disrupt the mechanism that the intracellular forms of C. pneumoniae use to prevent normal celluar apoptosis, and it is believed that Vitamin D3 is active against the intracellular forms of C. pneumoniae through this mechanism. The resulting die-off effects from Vitamin D3 can be quite large, and symptoms of secondary pophryia can also be dramatically increased. Vitamin D3 levels should therefore be increased very slowly when treating a C. pneumoniae infection!

There is much controversy surrounding the optimum levels of Vitamin D3 supplementation, and while the currently established safe upper limit for Vitamin D3 is listed as 2000 IU per day for adults and children over the age of 12 months, many experts are now questioning this level and calling for the upper limit to be increased to levels as high as 10,000 IU:

National Institutes of Health Office of Dietary Supplements: Dietary Supplement Fact Sheet: Vitamin D
Risk assessment for vitamin D
Council for Respnsible Nutrition: Scientific Experts Call for Increased Vitamin D UL

Another method to obtain adequate levels of Vitamin D3 is through approximately 15-20 minutes of near full body exposure to the sun at peak sun times during the summer. In this amount of time at peak sun during peak sun months, our skin produces between 10,000 and 20,000 IU of Vitamin D3. No additional Vitamin D3 is produced in longer exposure, and peak levels are produced prior to any sunburn pinkness.

However, the time of the day, the season of the year, and the latitude you live in alter the the amount of UVB rays (the Vitamin D3 producing rays) you are exposed to as the following study from India points out:

UVA and UVB in sunlight, Optimal Utilization of UV rays in Sunlight for phototherapy

Even at high noon, UVB exposure varies so much by season, that you may have trouble getting enough Vitamin D3 in the near winter and winter months depending on your latitude as the diagrams of UVB exposure in various US cities by month in the following article show:

Estimations of the human vitamin D UV exposure in the USA

Vitamin D3 supplementation may be contraindicated in certain diseases including sarcoidosis, so please talk to your doctor before taking high level supplements of Vitamin D3.

 

Video: The Vitamin D Pandemic and its Health Consequences, Presented by Michael Holick, PhD, MD, Professor of medicine, physiology and biophysics and director of the General Clinical Research Center at Boston University Medical Center

Red, thanks for making this post and pulling all this information together.

Louise

CFS/ME.CPnPositive.BbPositive.WheldonCAPbegan6/24/07. NowNAC,Doxy, Roxi, Full TiniPulses. Cholestyramine at BedtimeforPhorphoria&liposacarideEndotoxinDie-OffExperiences.

  • CAP(TiniOnly): 06/07-02/09 for CFS
  • MethylationProtocolSupplements: Started08/08
  • Intermtnt CAP: 02/09-02/10
  • Full MethylProtocol & LDN 02/09
  • Off CAP: 02/10, cont LDN & MethlyProtocol support

Thanks for this Red.  In my Canadian news there was a small segment of a study of women with breast cancer.  Many of them were very deficient in vit. D.  some of these breast cancer survivors are popping the Vit. D (I hope it is the D3)

CFIDS/ME 26yrs, FMS, IBS, EBV, CMV, Cpn, chronic insomnia, Lymes, HME, Natural HRT peri-M, NAC 2.5 gm, 6-07 Doxy 200 mg day pm, Azith 375 mg M/W/Fday, Pulse#9 750mg 5.5 day, 4-25-8

CFIDS/ME, FMS, MCS, IBS, EBV, CMV, Cpn, H1, chronic insomnia, Chronic Lyme, HME, Babesia, Natural HRT-menopause, NAC 2.4 gm,Full CAP 6-2-07, all supplements+Iodorol, Inositol-depression, ultra Chitosan, L lysine Pulse#27 04-19-10 1gm Flagyl/day-5 days<

Ok Red, we've been slackin.' But I think it's time to take lots of those little white pills again! Thanks for this reminder. Lexy --------------- "Chance favors the prepared mind." --Louis Pasteur Husband treating MS with CAP
--------------- "Chance favors the prepared mind." --Louis Pasteur Husband treating MS with CAP

Awesome video, I only wish I could have seen the question period after his presentation. It would have been great to hear him talk about it.

best, John

RRMS/EDSS was 4.5, 5, 6, 6.5, 6.9999, 6.5 on Wheldon/Stratton Protocol beginning 04/12/2006
nac 4x600 mg/day
doxycycline 2x100mg/day
azithromycin 3x250mg/day MWF
metronidazole 3x400mg/day then 3x500mg/day

Red - I really appreciate your posts. This one (as usual) is excellent !

Daisy - Husband on CAP 5/07.  Husband died from Acute Myelogenous Leukemia Secondary to the Infusion of Novantrone.  Ie - the treatment with the conventional MS drugs killed him.

Daisy on her own CAP 11/2012. 

Red

A couple of other important and apparently previously unrecognized functions of of the cathelicidins (LL-37) upregulated by Vitamin D3:

 

 

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

I'm sure it's no coincidence that up here in the Northwest where we see the least amount of sun we have the highest rate of MS. And the greedy suncreen manufacturers' campaign to scare everyone into wearing suncreen 24/7 is only making things worse. I've seen ads telling people to wear sunscreen just to drive to work because that little bit of sun hitting your left arm through the tinted car window is still "dangerous"! So now people I know even in sunny Southern California are probably not getting enough D because they've become so afraid of the sun they cover up or slather on the sunscreen just to get the newspaper off the front porch. The way the advertisers talk about the sun you'd think sunlight was some relatively recent toxic pollutant humans are not accustomed to and even a moment's exposure is harmful. Get real. The sun has been shining on Earth for billions of years. We are not allergic to it. We need it to live like all life does. Don't fear it. Just don't get stupid with it and you're fine.

Although, since so many here have to avoid the sun because of doxy side effects it's especially important to take D supplements. 

Wow! Red this is a terrific! You have been busy and we all benefit so much from it!  Thank you. I know it will take me a bit to read them all right now but I am quite excited to dig in.

Many thanks!
Corinna 

Corinna | GFA. Wheldon Protocol: 4–8/08. Can't kill the yeast.

Vitamin D Deficiency - 'A Disease of Neglect' and Its Unrecognized Toll

ImmuneSupport.com

07-25-2008

The above link has some key points from Dr M Holick's fascinating video presentation - “The Vitamin D Pandemic and Its Health Consequences” such as:


Can you make any vitamin D in winter?
Little or none, if you live above the 35th latitude north or south of the equator. That's only slightly north of such 'southern' cities as Atlanta, Georgia, which is at 33 north. In a study, subjects exposed to sunlight in Boston (42.19 north) were able to make “zero vitamin D” from November through February. To check the latitude where you live: 

Latitude-Longitude of World Cities - click on link on top of page for US Cities

NAC 2.4g, Zith 250mg/MWF, mino 200mg, Tini 5day/1g/5 pulses, Valcyte
Supplements, CFIDS/FMS, Hashimoto's, Psoriasis, PA, IBS, Sec Addisons

Don't believe everything you think!  

My husband and I live in the Pacific Northwest near Seattle. We're at 47.6º latitude. We average only 58 sunny days a year, mostly around June-Aug I'd say. My husband has a "Dr. Dumb" for a physician. In Feb he went in for his annual blood tests and I told him to ask his doctor to do a Vit D test, which they don't normally do. She almost refused arguing that, because he worked in the yard on Saturdays, "getting outside regularly", he would not need to worry about it. When he told me that my jaw hit the floor. Feb, in Seattle, outside one day a week covered from head to foot in warm clothing, and this dumber-than-dumb doc thinks he gets enough sunlight to provide sufficient vitamin D?!! That does not take a brain surgeon to figure out there's no sun exposure there. What the *BLEEP* was she thinking?

Well, he got her to give him the Vit D test, despite her know-it-all objections, and it was only 21 (normal 30-150) and, can you believe, no apology, no admission of surprise even. She had the audacity to scold and lecture him for not taking enough vitamin supplements! He had, actually, been taking a multi vitamin with the min 400iu D daily for quite some time. Obviously not enough.

 

Sunni- When in doubt, blame the patient. Your husband's results are instructive, thanks for the report.

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Wow, Red this thread is a gem and a half. Great work and wonderful effort getting all this combined in a single page. Sunni, that is hilarious.... No wonder medicine is in such a tail spin. marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

Red

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

This may repeat some of what's here, but I've taken to putting all new abstracts I or others find into a section of the Research pages "handbook" (using the book format in drupal) here:

http://www.cpnhelp.org/vitamin_d_abstracts

Lot's of good stuff, quite a bit of it found by Red!

 

CAP for Cpn 11/04. Dx: 25+yrs CFS & FMS. Currently: 250 aithromycin mwf, doxycycline 100mg BID, restarted Tini pulses; Vit D2000 units, T4 & T3, 6mg Iodoral

Really great resource Jim! Thanks! marie

On CAP since Sept '05 for MS, RA, Asthma, sciatica. EDSS at start 5.5.(early cane) Now 6 (cane full time) Originally on: Doxy 200, Azith 3x week, Tini cont. over summer '07, Revamp of protocol in Summer '08 by Stratton due to functional loss; clarithro

Red

It's lookin' good, Jim.  Thanks!

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-
Red

Here's a good review article on Vit D3:

Use of Vit D in Clinical Practice 

Note the discussion on the prescription form of Vit D (Vit D2) and the resulting unnatural metabolic by-products in the 2nd to last paragraph on page 13 above.  Here's the article that the above article refers to in support of Vit D3 over Vit D2:

The case against ergocalciferol (vitamin D2) as a vitamin supplement

 

 

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-

Red,

I appreciate all the info on vitamin d.  It's overwhelming and sooooo many threads.  We are going to Kim's neuro appt next week.

1) What are the best questions to ask Kim's doctor regarding D3?

2) What is the blood test result I would ask about and how is it measured?

3) Are there recent medical journal articles that explain the reasons D3 is being recommended?

Thanks, Ken

In pursuit of ABX

Don't Allow What You Know To Get In The Way Of What Might Be

Red

Hi Ken,

Print out and take a copy of this article (while it's in an alternative medicine journal, it's a really good guide):

Use of Vit D in Clinical Practice 

I certainly have no medical background, but I believe you want a blood draw for a 25(OH)D test, and according to the article above, you want to make sure blood levels are in the 50-70ng/mL range year-round, perhaps even in the 50-80ng/mL range as the Vitamin D Council site is recommending on the home page (note some experts suggest even higher doses for cancer and other diseases (such as MS):

http://www.vitamindcouncil.org/

Also, print this article out and take to your Neuro:

Safety of vitamin D3 in adults with multiple sclerosis

If Kim's neuro is concerned about hypercalcemia, and given the studies above, he really shouldn't be all that concerned about it in doses as high as 10,000iu / day, have him also run a blood calcium test to ensure levels are within the normal range.   This is probably a waste of a test, but if it makes the Neuro feel more comfortable, what the heck...

Hope this helps...

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-
Red

Thanks Anne!

Treatment for Rosacea

  • CAP:  01/06-07/07
  • High-Dose Vit D3, NAC:  07/07-11/08
  • Intermtnt CAP, HDose Vit D3:  11/08-01/09
  • HDose Vit D3, Mg, Zn: 01/09-