27 Apr 2018
Author
rilke
Title

Igg Titer Question

Body

I just got labs back from my ME/CFS doctor. My c. pneumonia Igg Titers are 1:1024 through Quest. I haven't been able to talk to my MD yet but I have a few questions. Does this mean I have an active infection?Also, my cholesterol is quite high. I've never had issues with high cholesteraol and heart disease does not run in my family (I'm 50 years old). Is there a connection between these?Will treating cpn help me feel better? I'm housebound.  I'll review more of the material on this site and ask more questions.

Comments

While you're reading, you might want to look at the book, "The Potbelly Syndrome". It will explain a lot of the relationships you're asking about.

The difference between what we do and what we are capable of doing would suffice to solve most of the world’s problems. Mohandas Gandhi

Thanks for the suggestion MacKintosh. I just looked at the site for the book. There's a lot of great information there and its fascinating as well. I've bookmarked it so I can go through it more thoroughly.

Severe ME/CFS diagnosed 2007. Postural Orthostatic Tachycardia Syndrome, Bartonella, EBV, HHV6, Mycoplasma, and CPn IgG 1:1024; currently on Valtrex, Famvir, and slowly working my way up to full dosage of NAC. Will start CAP protocol when I can tolerate N

I'm assuming you have ME/CFS since you say you have an ME/CFS doctor.  I have CFS, and treating bacterial and viral infections have helped me feel better.  I have high IgG and high IgA antibody titers to Cpn (at times as high as the lab measures)....Do I have Cpn?  I don't know.  At this point we are treating as if it is a problem for me.  I get my labs done at Focus labs for Cpn.  (See the infection tab at this website):  http://chronicfatigue.stanford.edu/   You might want to get tested for viruses too....you may have more than one pathogen making you ill.  That seems to be the case for me.Best, Timaca 

on valtrex 500 mg tidhttp://whispersfromthefather.me/   

Thanks Timica. I do have severe ME/CFS. I've been tested for various viruses and am positive for HHV 6, EBV. I took Valcyte for 7 months but had to stop due to elevated liver enzymes. I'm currently on Famvir and Valtrex. I'm trying to figure out whether the titers I posted are worth attempting to treat CPN. I've been on various antibiotics over the past few years to treat lyme (I don't believe I have lyme) and am not eager to  go back on them. I tried taking Rifampin a couple months ago to treat suspected Bartonella and it was so rough I had to stop after 7 days.

Severe ME/CFS diagnosed 2007. Postural Orthostatic Tachycardia Syndrome, Bartonella, EBV, HHV6, Mycoplasma, and CPn IgG 1:1024; currently on Valtrex, Famvir, and slowly working my way up to full dosage of NAC. Will start CAP protocol when I can tolerate N

Hello, rilke and welcome.....If your doctor hasn't run a complete thyroid panel on you, I would strongly suggest it.  Not just the TSH but rather FT3, Ft4, and thyroid antibodies.  Perhaps this has already been checked since you have CFS?   One of the first things to check when cholesterol levels start getting high is the function of your thryoid, THEN address diet if the thyroid is okay.  Most doctors don't do this but rather start shoving pharmaceuticals for high cholesterol (without telling you to take CoQ10)  My mother-in-law is in this drug allopathic loop and it's sad... they won't even see if she is hypothyroid and she is getting weaker and lethargic from the cholesterol meds.  The fact you have high IgG tires may be blown off by doc's (most) because they were "taught in medical school" that this is only indicative of having been "exposed" to this bacteria and you have built antibodies against it.  Did they run a IgM and IgA as well?   It would be interesting to see those numbers.....  High IgM titers are indicative of a recent infection and hihg IgM titers in recurrent or chronic infections.

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

Thanks for the welcome and great suggestions. I'm pretty concerned about the high cholesterol. My doctor did run a Thyroid panel on me.T3, Free =  3.1TSH 3rd generation =1.82T4 = 1.0  I've been taking Westhroid (similar to Armour Thyroid) for the past 2 years. It looks like my IgM titers were 1.10. There was no IgA run. That's interesting about the relationship between thyroid function and cholesterol. I think I'll try taking coq10 again to see if I can bring down the cholesterol numbers. They just shot up in the last 2 years for some reason. So it sounds like I don't need to worry about cpn being part of my clinical picture. I also have postural orthostatic tachycardia syndrome. I don't eat meat, fats, or any of the foods that are said to cause high cholesterol.

Severe ME/CFS diagnosed 2007. Postural Orthostatic Tachycardia Syndrome, Bartonella, EBV, HHV6, Mycoplasma, and CPn IgG 1:1024; currently on Valtrex, Famvir, and slowly working my way up to full dosage of NAC. Will start CAP protocol when I can tolerate N

I wouldn't discount CPN quite yet but sometimes it's very difficult to determine what pathogens we really are harboring.  And, we are all so physiologically unique.   Have you tried taking NAC to see how you react? I had my thyroid ablated (RAI) about 23 yrs ago, I personally believe it was the CPN back then starting to cause problems.  I too have HHV6 and EBV, but have not (yet?) taken antivirals.  After starting ABX treatment I developed major HPA issues (orthostatic hypotension) so severe I couldn't stand up (as well as some other problems).  With me I have had to adress my adrenals as the stealth infection created(es)stress which starts another whole snowball effect.  My thryoid levels are fine, but the adrenal issue creates problems for me... it's better but not yet normal.  (Will I ever be normal again, LOL?) Others here have found they have had to adjust their thyroid meds, once they start treatment as CPN does affect the thyroid. Have they adjusted (increased) your thyroid meds at all in these 2 years?  Have you ever monitored your temperature to see if it is below normal (if so, possibly not enough thyroid, and could be your adrenals).  I, too, take natural (ERFA) thryoid... my liver could not convert the Synthroid and cause major issues for me. Lot's to read and learn here... I wouldn't discount that you don't have CPN..... try the NAC and see what happens ;)  

JeanneRoz ~ DX'd w/ CPN 4/2007; 6/07 -"officially" dx'd w/CFIDS/FM; also: HHV6, EBV, IBS-C, 100 Doxy:BID; 500 mg Biaxin BID; Tindamax Pulses, B12 shots, ERFA Dessicated Thyroid,Cortef, Iodoral 25 mg, Vit D-6,000 uni

rilke~  It might be worth running an IgA for Cpn.  I don't think there is any good way to determine if one has Cpn by a blood test as you can be seronegative and have it.  However, if you have a high IgG, which you do, then perhaps it is an issue for you (although totally healthy people can have a high IgG titer).  But, maybe an IgA test gives a better glimpse as to whether or not it is a concern.  Here's a test you can run:  http://www.focusdx.com/focus/1-reference_laboratory/search_frame.asp?searchOptionScope=2&S1=1&S2=1&test=&sp=23120&Keyword=chlamydia%20pnemonia%20IgA#an_23120I would also suggest getting tested for enterovirus as that can also contribute to CFS symptons. See:http://chronicfatigue.stanford.edu/infections/entero-tests.htmlBest, Timaca 

on valtrex 500 mg tidhttp://whispersfromthefather.me/   

Thanks again for the info JeanneRoz. When I first got sick 4 years ago I tried taking a bunch of supplements including NAC. I didn't feel good on them and figured out that when I eliminated NAC I didn't feel as bad. Taking NAC has caused me to feel worse but I haven't tried it lately. Do you have ideas about why the antibiotics caused the severe HPA issues? Unfortunately my doctor hasn't been the best at tracking my thyroid. I reduced the thyroid med about 1 year ago but recent bloodwork seems ok. I also take a low dose of hydrocortisone to help my poorly functioning adrenals. I think I'll buy some NAC and do the recommended test to see how I feel. It's fascinating how all this is interconnected. I'd be more fascinated if it wasn't me suffering from it. Lol.

Severe ME/CFS diagnosed 2007. Postural Orthostatic Tachycardia Syndrome, Bartonella, EBV, HHV6, Mycoplasma, and CPn IgG 1:1024; currently on Valtrex, Famvir, and slowly working my way up to full dosage of NAC. Will start CAP protocol when I can tolerate N

Thanks again Timica. I'll have my doc run the IgA. He's an infectious disease doc that used to be at Stanford. I'm surprised he didn't run the IgA. I've never been tested for enteroviruses. It sounds like it might be a good idea. Thanks for posting the links!

Severe ME/CFS diagnosed 2007. Postural Orthostatic Tachycardia Syndrome, Bartonella, EBV, HHV6, Mycoplasma, and CPn IgG 1:1024; currently on Valtrex, Famvir, and slowly working my way up to full dosage of NAC. Will start CAP protocol when I can tolerate N

Timica-how did you know I saw Dr. Kogelnik?  I'm not sure if I'll continue with him. I can't get responses to emails to discuss the lab results. There are some other issues too which I wont' go into here. I really liked him and was impressed on the initial visit but  the follow up wasn't good. A couple friends also had a similar experience. I'm not sure what the issue is and plan on writing him a letter just so he has feedback. I expressed concern to his assistant and still I can't get a returned phone call to go over my labs (there were lots of concerning numbers-liver function tests came back high, etc... so I really needed to talk with him).   

Severe ME/CFS diagnosed 2007. Postural Orthostatic Tachycardia Syndrome, Bartonella, EBV, HHV6, Mycoplasma, and CPn IgG 1:1024; currently on Valtrex, Famvir, and slowly working my way up to full dosage of NAC. Will start CAP protocol when I can tolerate N

Timica-thanks for posting the article. I had no idea (I just started seeing him). I spoke with another doc who has been treating my cfs. he thinks my igg levels are worth treating so i'll start on doxy and zith at low doses. i decided to stop seeing kogelnik. he doesn't seem to have anything to offer in the way of treatment. plus i do believe that a retrovirus is the root of me/cfs. i'm a bit shocked that kogelnik was one of the authors disputing the wpi's xmrv research.

Severe ME/CFS diagnosed 2007. Postural Orthostatic Tachycardia Syndrome, Bartonella, EBV, HHV6, Mycoplasma, and CPn IgG 1:1024; currently on Valtrex, Famvir, and slowly working my way up to full dosage of NAC. Will start CAP protocol when I can tolerate N

Good luck on the doxy and zith.  I am on doxy and rifampin.  Lots of studies have disputed WPIs findings.   I will be quite interested to see the results of Lipkin's and Montoya's study (see # 1).  The results should be out in early 2012:   http://chronicfatigue.stanford.edu/about/projects.htmlhttp://www.bloomberg.com/news/2011-05-31/chronic-fatigue-study-that-sparked-ban-may-have-been-flawed.html?forumid=331851You might also want to get tested for enteroviruses.  They are part of my problem and others that I know:  http://chronicfatigue.stanford.edu/infections/entero.htmlBest, Timaca 

on valtrex 500 mg tidhttp://whispersfromthefather.me/